Delayed irritation: Hexanediol diacrylate and butanediol diacrylate

Malten, K. E.; Arend, Jörg; Wiggers, R. E.

doi:10.1111/j.1600-0536.1979.tb04834.x

Cited by 76 publications

(23 citation statements)

References 7 publications

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“…However, nasal obstruction and hypersecretion as well as an increased incidence of common colds has been reported in wood furniture workers [Ruppe, 1973;Wilhelmsson and Drettner, 19841. These symptoms seem to correlate with wood dust concentration [Andersen et al, 19771. Inflammation, skin irritation, and allergic contact dermatitis from exposure to acrylates are, potentially, the most likely health effects to workers [Bjorkner et al, 1980;Emmet, 1977;Malten, 1979;Malten et al, 1979;Nethercott, 1981;Nethercott et al, 1983;Whittington, 19811. However, no studies have been published, to our knowledge, on health complaints and/or pathophysiology in upper airways in workers exposed to multifunctional acrylates.…”

Section: Discussionmentioning

confidence: 99%

Upper airway symptoms and function in wood surface coating industry workers

Holmström¹,

Granstrand²,

Nylander‐French³

et al. 1995

American J Industrial Med

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Respiratory and ocular effects from exposure to airborne contaminants in workers employed in the manufacture of wood products using ultraviolet radiation curing (UV) or acid curing (AC) of surface coating were investigated. Surface coating line or finishing workers exclusively employed in one or both processes were compared to a control group. Symptoms of exposure were investigated by questionnaire and medical examination. Nasal, pharyngeal, and ocular symptoms of discomfort, but not lower airway, were common among all exposed groups. These symptoms were most frequent in UV line workers and finishers of UV surface-coated wood products. Mucociliary clearance was significantly slower in UV line workers. Significantly higher olfaction thresholds were observed in UV line and AC line workers and finishers of UV/AC surface-coated wood products. Low levels of organic solvents and coating dusts (composed in part of wood dust, chemical composition unknown) were measured in the workers' breathing zones. Although remarkable improvements have been made in both AC and UV surface coating, additional control measures to eliminate airborne contaminants and improved work practices are required.

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Section: Discussionmentioning

confidence: 99%

Upper airway symptoms and function in wood surface coating industry workers

Holmström¹,

Granstrand²,

Nylander‐French³

et al. 1995

American J Industrial Med

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“…This started with the identification of this pattern of irritation in the 1970s by Malten. He studied the symptoms of occupational workers exposed to a variety of chemicals that led to a number of similar symptoms that seemed to indicate allergic contact dermatitis, but yet were not sensitized [50,51]. Malten also was the first to use instrumental measurements for water loss and skin impedance to characterize skin damaged by cumulative irritation [52].…”

Section: Methodsmentioning

confidence: 99%

“…He found that occupational contact of the workers to hexanediol diacrylate and butanediol diacrylate resulted in delayed irritant dermatitis as exhibited by a different clinical picture than contact sensitization [50]. This discrimination was the first recorded to demonstrate the importance to clinicians who can be misled in initial identification of irritant dermatitis as allergic contact dermatitis.…”

Section: Clinical Aspectsmentioning

confidence: 97%

“…When DIPHOTERINE ® solution was compared to SLS (sodium lauryl sulfate) in a murine fibroblast MTT cytotoxicity assay, the estimated IC 50 of SLS was 0.258 mg/mL whereas that of DIPHOTERINE ® solution was 5 mg/mL even after 24 h of incubation. Thus, DIPHOTERINE ® solution had no cytotoxic effects on murine fibroblasts [256].…”

Section: Cytotoxicity In Murine Fibroblastsmentioning

confidence: 99%

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Damaged Skin

Burgher¹,

Mathieu²,

Blomet

et al. 2014

Chemical Skin Injury

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“…Irritant reactions generally decrease in intensity after removal of the patch but late maximal inflammation can be seen (13,14). Reproducible reactions are generally allergic in nature, while irreproducible reactions are more likely to be irritant, as demonstrated by Kligman & Basketter (12).…”

Section: Irritancy and "False-positive" Reactionsmentioning

confidence: 99%

The value and limitations of rechallenge in the guinea pig maximization test

1996

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The guinea pig maximization test (GPMT) has played a primary role in the evaluation of potential skin contact sensitizers for 25 years. In the OECD Guideline 406 from 1993, it is specifically suggested that equivocal results from the initial challenge in the GPMT should be evaluated further with a repeated challenge. However, there exist few published rechallenge data and the guideline does not describe how rechallenge data should be interpreted. In this paper, we have used examples from published results to illustrate both the positive value and the limitations of repeated challenges, including cross challenge. Testing with modified concentrations may also help to indicate whether or not the response is allergic in nature, particularly where there has been a low level of skin reaction observed in shamtreated controls, or where a low level of skin reaction is the dominant response in the test animals. In conclusion, the data presented demonstrate that, as a tool for the investigation of skin sensitizing potential, the GPMT can benefit from an experienced scientific evaluation of rechallenge data, but that this information should not be treated in a mechanistic fashion.

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Delayed irritation: Hexanediol diacrylate and butanediol diacrylate

Cited by 76 publications

References 7 publications

Upper airway symptoms and function in wood surface coating industry workers

Upper airway symptoms and function in wood surface coating industry workers

Damaged Skin

The value and limitations of rechallenge in the guinea pig maximization test

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