Delayed maturation and altered proliferation within the rat rostral migratory stream following maternal deprivation

Lievajová, Kamila; Blasko, Juraj; Martončı́ková, Marcela; Cigánková, Viera; Račeková, Enikő

doi:10.4081/ejh.2011.e33

Cited by 11 publications

(6 citation statements)

References 39 publications

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“…The medial and anterior regions of the RMS show a higher glial proliferation than the posterior region [ 63 ]. Thus, sexual activity, maternal care, and hormones modulate cell proliferation differently in each of the RMS subregions [ 41 , 53 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

et al. 2020

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Microtus ochrogaster is a rodent with a monogamous reproductive strategy characterized by strong pair bond formation after 6 h of mating. Here, we determine whether mating-induced pair bonding increases cell proliferation in the subventricular zone (SVZ), rostral migratory stream (RMS), and dentate gyrus (DG) of the hippocampus in male voles. Males were assigned to one of the four groups: (1) control: males were placed alone in a clean cage; (2) social exposure to a female (SE m/f): males that could see, hear, and smell a sexually receptive female but where physical contact was not possible, because the animals were separated by an acrylic screen with small holes; (3) social exposure to a male (SE m/m): same as group 2 but males were exposed to another male without physical contact; and (4) social cohabitation with mating (SCM): males that mated freely with a receptive female for 6 h. This procedure leads to pair bond formation. Groups 2 and 3 were controls for social interaction. Male prairie voles were injected with 5-bromo-2′-deoxyuridine (BrdU) during the behavioral tests and were sacrificed 48 h later. Brains were processed to identify the new cells (BrdU-positive) and neuron precursor cells (neuroblasts). Our principal findings are that in the dorsal region of the SVZ, SCM and SE m/f and m/m increase the percentage of neuron precursor cells. In the anterior region of the RMS, SE m/f decreases the percentage of neuron precursor cells, and in the medial region SE m/f and m/m decrease the number of new cells and neuron precursor cells. In the infrapyramidal blade of the subgranular zone of the DG, SE m/m and SCM increase the number of new neuron precursor cells and SE m/m increases the percentage of these neurons. Our data suggests that social interaction, as well as sexual stimulation, leads to pair bonding in male voles modulating cell proliferation and differentiation to neuronal precursor cells at the SVZ, RMS, and DG.

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Section: Discussionmentioning

confidence: 99%

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

et al. 2020

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“…In mice, the thickness of the SVZ and RMS decreases gradually but significantly from birth to adulthood [ 82 ]. Besides that, the overall appearance and size of rodent SVZ and RMS can be affected by various extrinsic factors [ 74 ]. Since the impact of aging [ 83 ] and particular experimental interventions [ 74 , 84 ] on the morphology of the SVZ/RMS neurogenic niche is well established, the effect of dietary patterns or obesity has not been studied yet.…”

Section: Discussionmentioning

confidence: 99%

“…It is very likely that the increase in the SVZ/RMS thickness in mouse with elevated/decreased body fat can be evidence of retardation in the SVZ/RMS development. Overnutrition can be related to adverse perinatal events that affect structural brain development [ 87 , 88 , 89 , 90 ] or cause delayed maturation of the SVZ/RMS [ 74 ].…”

Section: Discussionmentioning

confidence: 99%

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Maternal High-Energy Diet during Pregnancy and Lactation Impairs Neurogenesis and Alters the Behavior of Adult Offspring in a Phenotype-Dependent Manner

Fabianová

Babeľová

Fabian

et al. 2022

IJMS

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Obesity is one of the biggest and most costly health challenges the modern world encounters. Substantial evidence suggests that the risk of metabolic syndrome or obesity formation may be affected at a very early stage of development, in particular through fetal and/or neonatal overfeeding. Outcomes from epidemiological studies indicate that maternal nutrition during pregnancy and lactation has a profound impact on adult neurogenesis in the offspring. In the present study, an intergenerational dietary model employing overfeeding of experimental mice during prenatal and early postnatal development was applied to acquire mice with various body conditions. We investigated the impact of the maternal high-energy diet during pregnancy and lactation on adult neurogenesis in the olfactory neurogenic region involving the subventricular zone (SVZ) and the rostral migratory stream (RMS) and some behavioral tasks including memory, anxiety and nociception. Our findings show that a maternal high-energy diet administered during pregnancy and lactation modifies proliferation and differentiation, and induced degeneration of cells in the SVZ/RMS of offspring, but only in mice where extreme phenotype, such as significant overweight/adiposity or obesity is manifested. Thereafter, a maternal high-energy diet enhances anxiety-related behavior in offspring regardless of its body condition and impairs learning and memory in offspring with an extreme phenotype.

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“…BrdU immunohistochemistry has regularly been applied for estimating proliferating cells number in the main neurogenic region of the brain under physiological conditions [24] and in experimental interventions [25,26]. The more recently introduced marker, Ki-67 is also commonly used for detection of proliferation in the brain [27] and the spinal cord [16]. However, there are very few studies comparing proliferation activity with the use of both markers in the same CNS structure [28,29].…”

Section: Discussionmentioning

confidence: 99%

Regional differences of proliferation activity in the spinal cord ependyma of adult rats

et al. 2012

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Increased proliferation activity in the central canal ependyma of adult rodent spinal cord was described after injury and is thought to participate in recovery processes. Proliferation activity is scarce under physiological conditions, but still could be of importance, as in vitro studies showed that the spinal cord ependyma is an internal source of neural stem cells. Data from these studies indicate that there are regional differences in the distribution of proliferation activity along the rostro-caudal axis. We analyzed the proliferation activities in the ependyma within the entire extent of intact adult rat spinal cord. To identify proliferating cells we performed immunohistochemistry either for cell cycle S-phase marker BrdU or for the nuclear protein Ki-67. BrdU and Ki-67 positive cells were counted on sections selected from four spinal cord regions — cervical, thoracic, lumbar and sacral/coccygeal. Analysis showed that the number of BrdU positive cells within the ependyma was very low in all subdivisions of the spinal cord. Both BrdU and Ki-67 labeling revealed a significantly higher number of proliferating cells in the ependyma of sacrococcygeal part in comparison to all other spinal cord regions, suggesting that the caudal spinal cord might have potentially higher regeneration capacity compared to more rostral parts.

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Delayed maturation and altered proliferation within the rat rostral migratory stream following maternal deprivation

Cited by 11 publications

References 39 publications

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

Maternal High-Energy Diet during Pregnancy and Lactation Impairs Neurogenesis and Alters the Behavior of Adult Offspring in a Phenotype-Dependent Manner

Regional differences of proliferation activity in the spinal cord ependyma of adult rats

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