Delayed-Onset Bilateral Diffuse Uveal Melanocytic Proliferation Associated With Gastric Adenocarcinoma

Dolz-Marco, Rosa; Vilaplana, F.; Gallego-Pinazo, Roberto; Freund, K. Bailey

doi:10.1097/icb.0000000000000429

Cited by 9 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gastric adenocarcinoma was rarely reported to be associated with BDUMP. Dolz-Marco et al [3] reported one delayed onset BDUMP case 17 years after total gastrectomy for gastric adenocarcinoma, with no evidence of primary cancer recurrence or second malignancy. Our case validated the association of gastric adenocarcinoma and BDUMP.…”

Section: Discussionmentioning

confidence: 99%

“…Plasmapheresis can theoretically remove plasma CMEP, but with variable effectiveness [6]. Intravitreal anti-vascular endothelium growth factor (VEGF) agents were proven effective in some cases with intra-retinal fluid [3]. Other interventions such as ocular radiation, sub-retinal fluid drainage, corticosteroids were generally unsuccessful [6].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis of bilateral diffuse uveal melanocytic proliferation unveils primary gastric adenocarcinoma: a case report

et al. 2020

View full text Add to dashboard Cite

Background: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is an extremely rare paraneoplastic syndrome, with most cases reported as secondary to female urogenital and male lung malignancies. We reported this case of BDUMP patient whose primary malignancy was gastric adenocarcinoma verified with gastroscopy and subsequent pathological test. Case presentation: A patient complaining blurred vision was suspected of bilateral diffuse uveal melanocytic proliferation (BDUMP), due to bilateral round oval patches at the posterior pole and cardinal signs in retinal angiography. Malignancy screening was suggested, and pathological report from gastroscopy confirmed the primary lesion as gastric adenocarcinoma. The patient chose palliative care due to late stage and unresectable nature of the malignancy. Conclusions: Identifying BDUMP warrants further investigation of a primary malignancy. Our case provided evidence for the link between gastric adenocarcinoma and BDUMP.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosis of bilateral diffuse uveal melanocytic proliferation unveils primary gastric adenocarcinoma: a case report

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Plasmapherisis or plasma exchange is another way to remove CMEP in the plasma, and these approaches have effectively improved the BCVA and exudative retinal detachment in some BDUMP patients (12,23,(32)(33)(34)(35)(36). In addition, anti-vascular endothelium growth factor agents and corticosteroids have been used to promote the absorption of subretinal fluid and improve the BCVA, although this treatment was not satisfactory (15,35,37).…”

Section: Treatmentmentioning

confidence: 99%

“…BDUMP usually occurs in patients with systemic malignant disease, specifically, ovarian carcinoma in women ( 4 , 7 – 10 ) and lung carcinoma in men ( 3 , 4 , 11 – 13 ). Occasionally, BDUMP is associated with gastric adenocarcinoma ( 14 , 15 ), colonic adenocarcinoma ( 16 ), bladder cancer ( 5 , 17 , 18 ), pancreatic carcinoma ( 19 ), or primary vitreoretinal lymphoma ( 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

Bilateral Diffuse Uveal Melanocytic Proliferation Secondary to Rectal Adenocarcinoma: A Case Report and Literature Review

Tong

Wang

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Background: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular syndrome that causes progressive visual loss in patients, and is associated with an underlying malignancy. Recently, the incidence of BDUMP has increased with the prolonged life expectancy of oncology patients.Case Presentation: We report a case of a 68-year-old man with significant visual loss in both eyes. The patient presented with a diffusely thickened choroid and ciliary body, extremely shallow anterior chamber, increased intraocular pressure, and cataract formation, accompanied by exudative retinal detachment in both eyes. He underwent a pars plana vitrectomy and choroidal biopsy, which revealed benign proliferation of melanocytes. A small amount of subretinal fluid persisted, and uveal thickness persisted in the early postoperative period. During the 1-year follow-up assessment, he underwent rectal tumor resection, and was pathologically diagnosed with rectal adenocarcinoma. Six months after the rectal tumor resection, the subretinal fluid was completely absorbed and the retina had reattached. The thickness of both the ciliary body and choroid had significantly decreased.Conclusion: This case report describes a rare paraneoplastic intraocular syndrome, BDUMP, which was associated with rectal adenocarcinoma. Treatment for the primary malignancy gradually improved the visual symptoms and signs.

show abstract

“…BDUMP usually occurs in patients with systemic malignant disease, most commonly ovarian carcinoma in women and lung carcinoma in men. Occasionally, it may be associated with gastric adenocacinoma [3], bladder cancer [4], or occur with primary vitreoretinal lymphoma [5,6].…”

Section: Introductionmentioning

confidence: 99%

Bilateral diffuse uveal melanocytic proliferation: A case report and literature review

Tong

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumors. Case presentation Here, we presented a patient, whose clinical manifestation was diffusely thickened choroid, shallow anterior chamber, cataract formation and exudative retinal detachment. Histopathologic examination for the biopsies from the choroid during the surgery showed the the tissue might be originated from melanocytes and with the benign biologic behavior. Therefore, the diagnosis for this patient was BDUMP, although there was no obvious history of malignancy until we prepared for this article. Conclusions This was a rare BDUMP clarified by ophthalmic manifestations and histopathologic examination, without clear history of systematic malignancy.

show abstract

Delayed-Onset Bilateral Diffuse Uveal Melanocytic Proliferation Associated With Gastric Adenocarcinoma

Cited by 9 publications

References 6 publications

Diagnosis of bilateral diffuse uveal melanocytic proliferation unveils primary gastric adenocarcinoma: a case report

Diagnosis of bilateral diffuse uveal melanocytic proliferation unveils primary gastric adenocarcinoma: a case report

Bilateral Diffuse Uveal Melanocytic Proliferation Secondary to Rectal Adenocarcinoma: A Case Report and Literature Review

Bilateral diffuse uveal melanocytic proliferation: A case report and literature review

Contact Info

Product

Resources

About