Delayed-Onset of Multiple Cutaneous Infantile Hemangiomas Due to Propranolol: A Case Report

Chacón, Rocío Porcel; González, J. del Boz; Morón, Juan Navarro

doi:10.1542/peds.2014-3053

Cited by 4 publications

(2 citation statements)

References 12 publications

(13 reference statements)

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“…Late proliferation can occur even after 24 months of age . Porcel Chacon et al . reported delayed onset of multiple cutaneous IH after 7 months of propranolol treatment for heart disease.…”

Section: Discussionmentioning

confidence: 99%

Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Kagami

Kaneko

Katori

2018

The Journal of Dermatology

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Infantile hemangiomas undergo rapid growth during early infancy followed by gradual involution. Infantile hemangiomas sometimes impair vital functions or cause disfigurement. Thirty-two Japanese patients between the ages of 1 and 4 months with proliferating infantile hemangiomas received oral propranolol on an outpatient basis. The success rate (complete or nearly complete resolution) at week 25 was 56% (18/32). Two patients dropped out because of a personal reason and moving out. Recurrence after termination of treatment was seen in six patients. Adverse events occurred in 16 patients. There were no adverse events on day 1 (initiation of treatment at a dose of 1 mg/kg per day) and day 8 (dose increase to 2 mg/kg per day). One patient was hospitalized due to pneumonia, and suspended propranolol for 26 days. Oral propranolol at 2 mg/kg per day is effective and safe in Japanese patients with infantile hemangiomas.

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“…Late proliferation can occur even after 24 months of age . Porcel Chacon et al . reported delayed onset of multiple cutaneous IH after 7 months of propranolol treatment for heart disease.…”

Section: Discussionmentioning

confidence: 99%

Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Kagami

Kaneko

Katori

2018

The Journal of Dermatology

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“…Late proliferation can occur even after 24 months of age or 21 months of the propranolol treatment . Porcel Chacon et al . reported delayed onset of multiple cutaneous IH after 7 months of propranolol treatment.…”

Section: Discussionmentioning

confidence: 99%

Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment

Kagami

Kaneko

Kishi

et al. 2018

The Journal of Dermatology

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Infantile hemangiomas are the most common tumor of childhood and undergo rapid growth during early infancy followed by gradual involution. After involution, residual lesions sometimes remain. Oral propranolol usually induces earlier involution and redness reduction of infantile hemangiomas. However, the optimal treatment duration is unknown and infantile hemangiomas sometimes recur after cessation of treatment. We report three Japanese patients with recurrent infantile hemangiomas on their cheek. These patients were a 1-month-old female baby with a superficial infantile hemangioma, a 3-month-old female baby with a mixed infantile hemangioma and a 4-month-old male baby with a mixed infantile hemangioma. Two of them also received pulsed dye laser treatment. They did not reach complete or nearly complete resolution of infantile hemangiomas at week 25. These patients experienced regrowth of their infantile hemangioma after 20 months of age and took propranolol after the age of 24 months. There were no severe adverse effects. Propranolol may not only be therapeutic but also prophylactic. Patients with infantile hemangiomas who have taken oral propranolol should be followed up at least 6 months after cessation of treatment, especially infantile hemangiomas on the cheek, and those with partial response to propranolol may require close attention in prolonged growth.

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Stress, catecholaminergic system and cancer

Križanová

Babula

Pacák

2016

Stress

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Stress as a modern civilization factor significantly affects our lives. While acute stress might have a positive effect on the organism, chronic stress is usually detrimental and might lead to serious health complications. It is known that stress induced by the physical environment (temperature-induced cold stress) can significantly impair the efficacy of cytotoxic chemotherapies and the anti-tumor immune response. On the other hand, epidemiological evidence has shown that patients taking drugs known as β-adrenergic antagonists ("β-blockers"), which are commonly prescribed to treat arrhythmia, hypertension, and anxiety, have significantly lower rates of several cancers. In this review, we summarize the current knowledge about catecholamines as important stress hormones in tumorigenesis and discuss the use of β-blockers as the potential therapeutic agents.

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Delayed-Onset of Multiple Cutaneous Infantile Hemangiomas Due to Propranolol: A Case Report

Cited by 4 publications

References 12 publications

Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Thirty‐two Japanese cases of infantile hemangiomas treated with oral propranolol

Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment

Stress, catecholaminergic system and cancer

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