Delayed-onset paraparesis in Lassa fever: A case report

Duvignaud, Alexandre; Doutchi, Mahamadou; Abejegah, Chukwuyem; Etafo, Ijeoma Chukwudumebi; Jaspard, Marie; Serra, Bernardo; Tricaud, E.; Lévy-Marchal, Claire; Anglaret, Xavier; Ahmed, Liasu Adeagbo; Adedosu, Akinola Nelson; Malvy, Denis; Ayodeji, Oladele Oluwafemi

doi:10.1016/j.ijid.2019.12.022

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Temporary or permanent unilateral or bilateral deafness has been reported to occur in ~30% of those who survive Lassa fever 73 , 78 – 80 . Other long-term sequelae in survivors include neurological and visual defects 81 – 83 . The risk of LASV recrudescence, as is well documented for Ebola virus 84 , 85 , has yet to be adequately investigated.…”

Section: Lassa Fever — a Variable Clinical Coursementioning

confidence: 99%

Lassa fever — the road ahead

Garry

2022

Nat Rev Microbiol

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Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a viral haemorrhagic fever (VHF) associated with a high case fatality rate. Despite advances, fundamental gaps in knowledge of the immunology, epidemiology, ecology and pathogenesis of Lassa fever persist. More frequent outbreaks, the potential for further geographic expansion of Mastomys natalensis and other rodent reservoirs, the ease of procurement and possible use and weaponization of LASV, the frequent importation of LASV to North America and Europe, and the emergence of novel LASV strains in densely populated West Africa have driven new initiatives to develop countermeasures for LASV. Although promising candidates are being evaluated, as yet there are no approved vaccines or therapeutics for human use. This Review discusses the virology of LASV, the clinical course of Lassa fever and the progress towards developing medical countermeasures.

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