Delayed peak latency of the mismatch negativity in schizophrenics and alcoholics

Kathmann, Norbert; Wagner, Michael; Rendtorff, Nicola; Engel, Rolf R.

doi:10.1016/0006-3223(94)00309-q

Cited by 80 publications

(59 citation statements)

References 15 publications

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“…The amplitude of the MMN has been found to be lower in alcoholics than in non-alcoholic controls [140]. The component has been proposed as an index of the brain inhibitory deficit associated with alcoholism [78,178]. Thus, as indexed by MMN and P300, alcoholics seem to exhibit impairments in early and in late cortical informationprocessing.…”

Section: Mismatch Negativity (Mmn)mentioning

confidence: 99%

Chronic alcoholism: Insights from neurophysiology

Campanella¹,

Petit²,

Maurage³

et al. 2009

Neurophysiologie Clinique/Clinical Neurophysiology

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SummaryIntroduction. -Increasing knowledge of the anatomical structures and cellular processes underlying psychiatric disorders may help bridge the gap between clinical signs and basic physiological processes. Accordingly, considerable insight has been gained in recent years into a common psychiatric condition, i.e., chronic alcoholism. Material and methods. -We reviewed various physiological parameters that are altered in chronic alcoholic patients compared to healthy individuals -continuous electroencephalogram, oculomotor measures, cognitive event-related potentials and event-related oscillations -to identify links between these physiological parameters, altered cognitive processes and specific clinical symptoms. Results. -Alcoholic patients display: (1) high beta and theta power in the resting electroencephalogram, suggesting hyperarousal of their central nervous system; (2) abnormalities in smooth pursuit eye movements, in saccadic inhibition during antisaccade tasks, and in prepulse inhibition, suggesting disturbed attention modulation and abnormal patterns of prefrontal activation that may stem from the same prefrontal ''inhibitory'' cortical dysfunction; (3) decreased amplitude for cognitive event-related potentials situated along the continuum of informationprocessing, suggesting that alcoholism is associated with neurophysiological deficits at the level of the sensory cortex and not only disturbances involving associative cortices and limbic structures; and (4) decreased theta, gamma and delta oscillations, suggesting cognitive disinhibition at a functional level. Discussion. -The heterogeneity of alcoholic disorders in terms of symptomatology, course and outcome is the result of various pathophysiological processes that physiological parameters * Corresponding author. E-mail address: salvatore.campanella@chu-brugmann.be (S. Campanella).

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Section: Mismatch Negativity (Mmn)mentioning

confidence: 99%

Chronic alcoholism: Insights from neurophysiology

Campanella¹,

Petit²,

Maurage³

et al. 2009

Neurophysiologie Clinique/Clinical Neurophysiology

View full text Add to dashboard Cite

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“…Decreased inhibition is thought to be reflected by larger MMN amplitudes (Zhang et al, 2001). Larger MMN amplitudes have been reported in studies of recently detoxified alcoholics (Kathmann et al, 1995) and in alcohol high-risk samples (Zhang et al, 2001). If increased MMN amplitude is associated with the vulnerability to alcoholism, it should be present in abstinent alcoholics and it should covary with factors known to predispose to alcoholism, such as a positive family history of alcoholism, conduct disorder and antisocial personality symptoms, or disinhibited personality traits (Finn et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…There has been some excitement about the use of the mismatch negativity (MMN) event-related brain potential as a measure of the brain inhibitory deficit associated with alcoholism or the vulnerability to alcoholism (Kathmann et al, 1995;Zhang et al, 2001). Decreased inhibition is thought to be reflected by larger MMN amplitudes (Zhang et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…While there are no doubts that acute alcohol ingestion delays MMN latency and reduces MMN amplitude, the long-term effects of chronic alcohol exposure are not as clear. One group of findings has found that abstinent alcoholics display increased MMN amplitude in comparison to control subjects (Ahveninen et al, 2000;Kathmann et al, 1995); however, these studies examined subjects with relatively shortterm (less than 2 mos) abstinence. This abstinence duration may have not been enough to get past the subtle post-withdrawal CNS hyperexcitablity associated with early cessation of alcohol, which have been shown to be detectable at 3-8 weeks after alcohol detoxification (Ahveninen et al, 2000) (Alling et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

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Mismatch Negativity: No Difference Between Controls and Abstinent Alcoholics

Fein

Whitlow

Finn

2004

Alcoholism Clin & Exp Res

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Background-A number of studies have examined the amplitude of the mismatch negativity (MMN) evoked potential as a measure of a brain inhibitory deficit in alcoholics or those at risk for alcoholism. The current study examined MMN in alcoholics abstinent an average of 6.7 years (with a minimum of six months abstinence) compared to controls. This study examined the association of MMN with alcoholism family history density, with indices of the presence and severity of externalizing disorders (a risk-factor for alcoholism), and with alcohol use variables.

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“…The MMN can be elicited by any occasional discriminable change in a sound sequence, irrespective of the direction of the subject's attention [18]; this process is therefore thought to be automatic and preattentive [19,20,21]. A reduction in MMN amplitude [22,23,24] and a prolongation of its peak latency [25] have been shown in patients with schizophrenia. Although several studies have revealed the areas in the gray matter that generate the MMN, predominantly in the temporal auditory cortex and frontal cortex [19,20], the relationship between the white matter and MMN has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Anterior Cingulate Abnormality as a Neural Correlate of Mismatch Negativity in Schizophrenia

et al. 2013

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Background: Limbic circuitry, especially the anterior cingulate gyrus, has been implicated in the pathophysiology and cognitive changes of schizophrenia. Previous diffusion tensor imaging studies have demonstrated that the integrity of the anterior cingulum (AC) is abnormal in schizophrenia. However, the relationship between the abnormal AC tract integrity and the pathophysiology of schizophrenia has not been fully studied. Methods: We performed a voxelwise group comparison of white matter fractional anisotropy (FA) by using tract-based spatial statistics in 9 patients with schizophrenia and 9 matched controls. We then measured FA specifically in the AC by using a tract-specific measurement. The latency and amplitude of the mismatch negativity (MMN) were also evaluated in all subjects. Results: In patients with schizophrenia, tract-based spatial statistics showed a reduction in FA in broad white matter areas, including the bilateral AC, compared with controls. Tract-specific measurements confirmed the specific reduction of FA in the region of the bilateral AC. The decreased FA in the AC was correlated with prolonged MMN latency in the patient group. Conclusion: Our study of AC structure and electrophysiological changes in schizophrenia suggest that the disruption of limbic-cortical structural networks may be part of the neural basis underlying the changes in MMN in schizophrenia.

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Delayed peak latency of the mismatch negativity in schizophrenics and alcoholics

Cited by 80 publications

References 15 publications

Chronic alcoholism: Insights from neurophysiology

Chronic alcoholism: Insights from neurophysiology

Mismatch Negativity: No Difference Between Controls and Abstinent Alcoholics

Anterior Cingulate Abnormality as a Neural Correlate of Mismatch Negativity in Schizophrenia

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