Delayed peritoneal dialysis catheter‐intestinal fistula

Yanai, Katsunori; Ueda, Yoshimichi; Minato, Saori; Kaneko, Shohei; Mutsuyoshi, Yuko; Ishii, Hiroki; Kitano, Taisuke; Shindo, Mitsutoshi; Aomatsu, Akinori; Miyazawa, Haruhisa; K, Ito; Hirai, Keiji; Hoshino, Taro; Ookawara, Susumu; Morishita, Yoshiyuki

doi:10.1111/nep.13204

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…The relationship of kidney function with subsequent cognitive decline in early PD patients remains unclear in previous studies although it has been studied that poor performances of kidney function are associated with an increased risk of cognitive impairment in the elderly population (Miyazawa et al, 2018;Fujiyoshi et al, 2020). These associations may be related to atherosclerosis, cerebral small vessel diseases, hematopoietic function impairment, or methylation metabolism that are secondary to CKD.…”

Section: Discussionmentioning

confidence: 99%

Estimated glomerular filtration rate is a biomarker of cognitive impairment in Parkinson’s disease

Qin

Wang

et al. 2023

Front. Aging Neurosci.

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BackgroundsThe relationship between kidney function and cognitive impairment in Parkinson’s disease (PD) is poorly understood and underexplored. This study aims to explore whether renal indices can serve as indicators to monitor the cognitive impairment of PD.MethodsA total of 508 PD patients and 168 healthy controls from the Parkinson’s Progression Markers Initiative (PPMI) were recruited, and 486 (95.7%) PD patients underwent longitudinal measurements. The renal indicators including serum creatinine (Scr), uric acid (UA), and urea nitrogen, as well as UA/Scr ratio and estimated glomerular filtration rate (eGFR), were measured. Cross-sectional and longitudinal associations between kidney function and cognitive impairment were evaluated using multivariable-adjusted models.ResultseGFR was associated with lower levels of cerebrospinal fluid (CSF) Aβ1–42 (p = 0.0156) and α-synuclein (p = 0.0151) and higher serum NfL (p = 0.0215) in PD patients at baseline. Longitudinal results showed that decreased eGFR predicted a higher risk of cognitive impairment (HR = 0.7382, 95% CI = 0.6329–0.8610). Additionally, eGFR decline was significantly associated with higher rates of increase in CSF T-tau (p = 0.0096), P-tau (p = 0.0250), and serum NfL (p = 0.0189), as well as global cognition and various cognitive domains (p < 0.0500). The reduced UA/Scr ratio was also linked to higher NfL levels (p = 0.0282) and greater accumulation of T-tau (p = 0.0282) and P-tau (p = 0.0317). However, no significant associations were found between other renal indices and cognition.ConclusioneGFR is altered in PD subjects with cognitive impairment, and predict larger progression of cognitive decline. It may assist identifying patients with PD at risk of rapid cognitive decline and have the potential to monitoring responses to therapy in future clinical practice.

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Section: Discussionmentioning

confidence: 99%

Estimated glomerular filtration rate is a biomarker of cognitive impairment in Parkinson’s disease

Qin

Wang

et al. 2023

Front. Aging Neurosci.

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“…However, complications, such as peritonitis, abdominal pain, and intestinal fistula, may occur [1,2]. Even with strict operating standards, complications cannot be avoided.…”

Section: Discussionmentioning

confidence: 99%

“…Some complications, such as peritonitis, pain, flow restriction, and exit-site leak, are common [1]. According to the literature, intestinal fistula is a rare complication of peritoneal dialysis [2]. The symptoms of intestinal perforation include watery diarrhea, difficulty in draining, and peritonitis [3].…”

Section: Introductionmentioning

confidence: 99%

Intestinal fistula accompanied by recurrent peritonitis associated with peritoneal dialysis: a case report

et al. 2020

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Background Intestinal perforation from peritoneal dialysis is rare, but the resulting complications are serious. Some patients do not necessarily have symptoms, and it can be difficult to differentiate their condition from PD-related (peritoneal dialysis-related) peritonitis, which may lead to misdiagnosis. Here we report a peritoneal dialysis patient with intestinal fistula associated with recurrent peritonitis. Case presentation A 44-year-old man had been treated for more than 6 years with peritoneal dialysis for chronic kidney disease stage-V. Abdominal computed tomography and electronic colonoscopy revealed an appendiceal fossa with adjacent fistula. The peritoneal dialysis catheter was removed, and the patient recovered with no recurrence of complications. Conclusion We report a case of a rare complication of peritoneal dialysis. The intestinal fistula in this patient was mainly caused by recurrent peritonitis and removal of the catheter could control the peritonitis.

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“…Injuries from trauma or by a foreign body can result in an abnormal fistulous connection due to a chronic granulomatous reaction [20].…”

Section: Non-surgical Injuries and Foreign Bodiesmentioning

confidence: 99%

Enterocutaneous Fistula: A Simplified Clinical Approach

Tuma

Crespi

Wolff

et al. 2020

Cureus

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Delayed peritoneal dialysis catheter‐intestinal fistula

Cited by 5 publications

References 2 publications

Estimated glomerular filtration rate is a biomarker of cognitive impairment in Parkinson’s disease

Estimated glomerular filtration rate is a biomarker of cognitive impairment in Parkinson’s disease

Intestinal fistula accompanied by recurrent peritonitis associated with peritoneal dialysis: a case report

Enterocutaneous Fistula: A Simplified Clinical Approach

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