Delayed photolysis of liposomes: a strategy for the precision timing of bolus drug release using ex-vivo photochemical sensitization

Kozikowski, Raymond T.; Sorg, Brian S.

doi:10.1117/12.909071

Cited by 1 publication

(2 citation statements)

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“…Porphyrin‐based PSs have also been formulated with liposomes and investigated for their photocytotoxicity potential. Kozikowski et al described a drug release mechanism based on a delayed photolysis using protoporphyrin IX (PpIX) as a PS . The photosensitized sample in a delayed photolysis system takes advantage of two distinct steps: (1) light‐initiated reaction, followed by (2) a thermally initiated reaction.…”

Section: Light‐responsive Liposomesmentioning

confidence: 99%

“…Kozikowski et al described a drug release mechanism based on a delayed photolysis using protoporphyrin IX (PpIX) as a PS. 156 The photosensitized sample in a delayed photolysis system takes advantage of two distinct steps: (1) lightinitiated reaction, followed by (2) a thermally initiated reaction. In an in vitro study, delayed photolysis-mediated calcein release was dependent on the PS concentration where 100 μM PpIX released 85% in 500 min and 1 μM PpIX released 60% in 1600 min after an initial 5-min irradiation (>600 nm).…”

Section: Light-responsive Liposomesmentioning

confidence: 99%

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Stimuli‐responsive liposomes for drug delivery

Lee

Thompson

2017

WIREs Nanomed Nanobiotechnol

373

190

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The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of the active pharmaceutical ingredient (API) by releasing at a specific site of action. In the case of antitumor therapy, association of the therapeutic agent with a carrier system can minimize damage to healthy, non-target tissues, while limit systemic release and promoting long circulation to enhance uptake at the cancerous site due to the enhanced permeation and retention effect (EPR). Stimuli-responsive systems have become a promising way to deliver and release payloads in a site-selective manner and carrier systems have been derived from a wide variety of materials, including inorganic nanoparticles, lipids, and polymers that have been imbued with stimuli-sensitive properties to accomplish triggered release. The unique features in the tumor microenvironment can serve as an endogenous stimulus (pH, redox potential, or unique enzymatic activity) or the locus of an applied external stimulus (heat or light) to trigger the controlled release of API. Triggered release is generally based on the principle of membrane destabilization from local defects within bilayer membranes to effect release of liposome-entrapped drugs. This review focuses on the literature appearing between November 2008–February 2016 that reports new developments in stimuli-sensitive liposomal drug delivery strategies using pH change, enzyme transformation, redox reactions, and photochemical mechanisms of activation.

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Section: Light‐responsive Liposomesmentioning

confidence: 99%

Section: Light-responsive Liposomesmentioning

confidence: 99%