Delayed Skin Allergy to Glucosamine Chondroitin Supplement

Chu, Eric Chun-Pu; Huang, Kevin Hsu Kai; Cheung, Gordon; Ng, Gabriel Siu Nam; Lin, Andy Fu Chieh

doi:10.7759/cureus.36310

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Nevertheless, additional studies are required to determine whether a causal relationship exists between HA supplementation, serum adropin levels, and clinical outcomes. While chondroprotective supplements are generally recognized as safe, it is important to acknowledge that they may pose certain risks, particularly hypersensitivity reactions in susceptible individuals [22]. Nevertheless, treatment-emergent adverse events were rare throughout the study, and no severe adverse reactions necessitated participant withdrawal from supplement use.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study

Minoretti,

Santiago Sáez,

Liaño Riera

et al. 2024

Cureus

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Background: Hyaluronic acid (HA), glucosamine (Glc), and chondroitin sulfate (CS) are key ingredients commonly incorporated into dietary chondroprotective supplements for the management of osteoarthritis (OA). Despite their widespread use, there is a paucity of published data regarding their efficacy and safety, necessitating rigorous investigation in clinical settings. To address this knowledge gap, we conducted a randomized, single-blind pilot study to evaluate the effects of two commercially available multi-ingredient supplements on patients with mild-to-moderate knee OA.Methods: A total of 51 patients diagnosed with mild-to-moderate knee OA were enrolled in a four-week randomized study and allocated equally (1:1:1 ratio) into three groups: a control group (n = 17) that received no treatment, an HA group (n = 17) given Syalox ® 300 Plus (1 tablet/day) containing HA (300 mg) and Boswellia serrata extract (100 mg), and a Glc + CS group (n = 17) given Cartijoint ® Forte (1 tablet/day) containing Glc (415 mg), CS (400 mg), and curcuminoids from rhizomes of Curcuma longa L (50 mg). Physicians conducting evaluations were blinded to group assignments, whereas patients were not. All participants underwent assessments of pain relief, functional capacity improvement, and serum adropin levels, an emerging biomarker of knee OA, at baseline and after the four-week intervention period.Results: Both the HA and the Glc + CS groups exhibited improvements at the end of the study relative to baseline, with statistically significant differences (p < 0.05) observed in pain at rest, pain during movement, range of motion, and the overall Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, including its pain, stiffness, and physical function subscales. Notably, the HA group outperformed the Glc + CS group in the alleviation of pain at rest, pain during movement, and on the WOMAC pain subscale, with all differences being statistically significant (p < 0.05). Additionally, both groups showed a significant elevation in serum adropin levels from baseline (p < 0.05), with the HA group experiencing a more substantial increase when compared to the Glc + CS group (p < 0.05). Both supplements showed a limited number of treatment-emergent adverse events. Conclusion:Oral supplementation with either HA or Glc + CS demonstrated potential benefits for managing symptoms of mild-to-moderate knee OA. Notably, HA supplementation was associated with greater improvements in pain relief and higher elevations in serum adropin levels compared to Glc + CS supplementation. However, larger-scale and longer-term studies are necessary to further evaluate the safety and efficacy of these dietary supplements within the clinical management arsenal for knee OA.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study

Minoretti,

Santiago Sáez,

Liaño Riera

et al. 2024

Cureus

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“…Patients with musculoskeletal and neuromusculoskeletal conditions must navigate unnecessary waits and referrals to access chiropractic care, increasing system burden [30]. In addition, as Hong Kong chiropractors often refer patients to nearby hospitals for urgent management [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47], the current system delays immediate emergency care. The lack of chiropractic exposure in medical education also perpetuates solid system and inter-professional barriers.…”

Section: Limited Inclusion Of Chiropractic Services In Public Healthc...mentioning

confidence: 99%

Meeting Future Demand for Chiropractic Services in Hong Kong: A Strategic Manpower Planning Approach

Ng¹,

Chu²,

Lam³

et al. 2023

Cureus

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Chiropractic treatment in Hong Kong has demonstrated high effectiveness in cases where traditional therapies have failed, with minimal associated adverse events. The growing aging population, prevalence of disabilities, and musculoskeletal conditions have increased the demand for rehabilitation services. Over the past few years, the chiropractic profession has raised awareness of treatment benefits. Providing high-quality training and education, licensing/regulation, interprofessional collaboration, increased accessibility, and research are factors influencing the chiropractic workforce and meeting the population’s health needs. To achieve the number of chiropractors required by Hong Kong for adequate service according to international standards, future efforts could include increased licensing/registration efficiency, expanded coverage of public/private insurance, system integration/interprofessional collaboration, public education, and local research to build evidence and to support workforce growth and acceptance.

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“…It is a key component of glycosaminoglycans and glycolipids, which are essential for the structure and function of cartilage in the joints of the human body (Nagaoka, 2019; Chen et al ., 2020). It is commonly used as a dietary supplement for the treatment of osteoarthritis (Chu et al ., 2023). Glucosamine is primarily derived via the hydrolysis of chitin, a highly abundant polymer found in nature and a major constituent of insect exoskeletons, crustacean shells, and fungal cell walls (Abo Elsoud & El Kady, 2019).…”

Section: Introductionmentioning

confidence: 99%

Debittering of salmon frame protein hydrolysate and plastein using Maillard reaction as affected by types of sugar

Sharma,

Nilsuwan,

Hong

et al. 2024

Int J of Food Sci Tech

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SummaryImpacts of Maillard reaction on bitterness, physicochemical properties, antioxidant activities of salmon frame protein hydrolysates (PH) and its plastein (PT) using ribose or glucosamine (Glx) were investigated. PT showed higher bitterness than PH after Maillard reaction, regardless of sugars and concentrations used (P < 0.05). PH (10%) and 4% Glx heated at 120 °C for 120 min yielded Maillard reaction products (MRPs) with the least bitterness (score: 5.89) as compared to control sample (P < 0.05). Browning intensity and lightness of aforesaid sample were directly and inversely proportional to treatment time, respectively. MRPs (10% PH with 4% Glx) showed the increased DPPH and ABTS radical scavenging activities (37.06 and 45.65 μmol TE g−1, respectively) up to 60 min (P < 0.05). Moreover, bitterness score of MRPS heated for 60 min was reduced from 9.37 (PH) to 1.44 ascertained by decrease in hydrophobic amino acid contents (P < 0.05). Therefore, Maillard reaction could be used as a promising means to lower bitterness of salmon frame PH.

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Delayed Skin Allergy to Glucosamine Chondroitin Supplement

Cited by 4 publications

References 10 publications

Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study

Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study

Meeting Future Demand for Chiropractic Services in Hong Kong: A Strategic Manpower Planning Approach

Debittering of salmon frame protein hydrolysate and plastein using Maillard reaction as affected by types of sugar

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