Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Talih, Farid; Gebara, Nour; Andary, Farah S.; Mondello, Stefania; Kobeissy, Firas; Ferri, Raffaele

doi:10.1016/j.smrv.2018.02.002

Cited by 26 publications

(13 citation statements)

References 101 publications

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“…In addition, BD individuals with a clear-cut evening chronotype exhibited an earlier age of illness onset, more frequent depressive and manic episodes, higher rates of rapid cycling, at least one suicide attempt, and a prior history of psychotic symptoms. Finally, BD patients with an evening chronotype are more likely to attempt suicide and have higher rates of comorbid anxiety and substance use disorders compared to BD patients who do not display an evening chronotype [ 18 – 21 ].…”

Section: Circadian Disturbances In Bdmentioning

confidence: 99%

Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder

et al. 2021

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Bipolar disorders (BDs) exhibit high heritability and symptoms typically first occur during late adolescence or early adulthood. Affected individuals may experience alternating bouts of mania/hypomania and depression, with euthymic periods of varying lengths interspersed between these extremes of mood. Clinical research studies have consistently demonstrated that BD patients have disturbances in circadian and seasonal rhythms, even when they are free of symptoms. In addition, some BD patients display seasonal patterns in the occurrence of manic/hypomanic and depressive episodes as well as the time of year when symptoms initially occur. Finally, the age of onset of BD symptoms is strongly influenced by the distance one lives from the equator. With few exceptions, animal models useful in the study of BD have not capitalized on these clinical findings regarding seasonal patterns in BD to explore molecular mechanisms associated with the expression of mania- and depression-like behaviors in laboratory animals. In particular, animal models would be especially useful in studying how rates of change in photoperiod that occur during early spring and fall interact with risk genes to increase the occurrence of mania- and depression-like phenotypes, respectively. Another unanswered question relates to the ways in which seasonally relevant changes in photoperiod affect responses to acute and chronic stressors in animal models. Going forward, we suggest ways in which translational research with animal models of BD could be strengthened through carefully controlled manipulations of photoperiod to enhance our understanding of mechanisms underlying seasonal patterns of BD symptoms in humans. In addition, we emphasize the value of incorporating diurnal rodent species as more appropriate animal models to study the effects of seasonal changes in light on symptoms of depression and mania that are characteristic of BD in humans.

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Section: Circadian Disturbances In Bdmentioning

confidence: 99%

Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder

et al. 2021

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“…They might also be useful as an adjunctive treatment for circadian rhythm issues for patients with BD, who are prone to exhibit the evening chronotype regardless of their mood state, 5 which is frequently influenced by DSWPD 34 . The evening chronotype is associated with depressive symptoms and suicidal ideation, 35,36 and DSWPD is a predictor of symptom relapse in BD 37 .…”

Section: Discussionmentioning

confidence: 99%

A double‐blind, randomized, placebo‐controlled trial of adjunctive blue‐blocking glasses for the treatment of sleep and circadian rhythm in patients with bipolar disorder

Esaki

Takeuchi²,

Tsuboi³

et al. 2020

Bipolar Disorders

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Objectives Recent studies have suggested that evening blue light exposure is associated with sleep and circadian rhythm abnormalities. This study examined the effect of blue‐blocking (BB) glasses on sleep and circadian rhythm in patients with bipolar disorder (BD). Methods We used a randomized, placebo‐controlled, double‐blinded design. Outpatients with BD and also with insomnia were randomly assigned to wear either orange glasses (BB) or clear ones (placebo) and were instructed to use these from 20:00 hours until bedtime for 2 weeks. The primary outcome metric was the difference in change from baseline to after intervention in sleep quality, as measured by the visual analog scale (VAS). Results Forty‐three patients were included in this study (BB group, 21; placebo group, 22). The change in sleep quality as per the VAS metric was not significantly different between the two groups (95% confidence interval [CI], −3.34 to 24.72; P = .13). However, the Morningness‐Eveningness Questionnaire score had shifted to an advanced rhythm in the BB group and to a delayed rhythm in the placebo group, and the difference in these changes was statistically significant (95% CI, 1.69‐7.45; P = .003). The change in the actigraphy sleep parameters and mood symptoms was not significantly different between the two groups. Conclusion Although concurrent medications may have influenced, our results suggest that BB glasses may be useful as an adjunctive treatment for circadian rhythm issues in patients with BD.

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“…Talih et al reported that dysfunctional melatonin and/or circadian biomarkers (eg, brain-derived neurotrophic factor) may also be involved in the pathophysiology of BD on account of their pivotal roles in delayed sleep phase syndrome. 10 Biological rhythm disturbance persists across all stages of BD, and over 80% of patients with BD reportedly exhibit dysfunction of biological rhythms. 11 A systematic review found that individuals at high risk for BD often experience irregular circadian rhythms.…”

Section: Influence Of Biological Rhythm Disturbance On Bdmentioning

confidence: 99%

Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review

Chen

Fang

2020

Gen Psych

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Disturbance of biological rhythms contributes to the onset of bipolar disorders and is an important clinical feature of the condition. To further explore the role of biological rhythms in bipolar disorders, 95 English articles published between 1968 and 2019 were retrieved from the PubMed database and analysed. We herein review the outcomes of studies on biological rhythm disturbance in bipolar disorders, including the epidemiology, aetiology, clinical features (eg, sleep, feeding and eating disorders) and treatment of the condition evaluated by patients’ self-report and biological indicators such as melatonin. Our report supports the characterisation of biological rhythm disturbance as a significant clinical feature affecting the onset and development of bipolar disorders and reviews classical and novel treatments, such as chronotherapy, that can be applied in the clinical practice. Our analysis indicates that a more comprehensive study of the pathophysiology, clinical phenomenology and treatment of biological rhythm disturbance is required.

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Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Cited by 26 publications

References 101 publications

Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder

Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder

A double‐blind, randomized, placebo‐controlled trial of adjunctive blue‐blocking glasses for the treatment of sleep and circadian rhythm in patients with bipolar disorder

Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review

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