Delayed Thrombogenesis Following Radiofrequency Catheter Ablation.

Sasano, Tetsuo; Hirao, Kazuyuki; Yano, Kazuo; Kawabata, Mihoko; Okishige, Kaoru; Isobe, Mitsuaki

doi:10.1253/circj.66.671

Cited by 13 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In regions of low convective cooling, conventional RF-CA systems may increase the risk of thrombus formation, even during the chronic stage. 22 In the present study, we did not observe any thrombus formation during the cooled-tip RF delivery. Crater formation is caused by tissue temperatures exceeding approximately 100°C, which causes evaporation of the tissue fluid.…”

Section: Safety Of the Cooled-tip Rf-ca Systemcontrasting

confidence: 41%

Clinical Study of the Efficacy of a Cooled-Tip Catheter Ablation System for Common Atrial Flutter

Okishige

Aonuma

Yamauchi

et al. 2004

Circ J

Self Cite

View full text Add to dashboard Cite

Section: Safety Of the Cooled-tip Rf-ca Systemcontrasting

confidence: 41%

Clinical Study of the Efficacy of a Cooled-Tip Catheter Ablation System for Common Atrial Flutter

Okishige

Aonuma

Yamauchi

et al. 2004

Circ J

Self Cite

View full text Add to dashboard Cite

“…The level of D-dimer may be sustained more than 3 days in cases of severe illness such as trauma or severe thromboembolic disease. 17 Delayed peaking of hemostasis during RF ablation has been reported recently; 18 it may result from sustained hemostatic activity or long-term effects of endothelial injury. In contrast, the level of D-dimer may become less sensitive and decrease immediately after anticoagulant therapy (not administered in our study); 19 however, it is still unclear how long the hemostasis process will continue after RF ablation.…”

Section: Discussionmentioning

confidence: 98%

Comparison of hemostatic activation created by right‐ and left‐heart radiofrequency catheter ablation

Charng

Lin

Chiu

et al. 2004

Clinical Cardiology

View full text Add to dashboard Cite

SummaryBackground: Thromboembolic complications commonly occur in radiofrequency (RF) ablation procedures (0.6-1.3% of cases). Comparison of hemostatic activation between left and right RF ablation is limited.Hypothesis: The purpose of this study was to evaluate platelet and hemostatic activation before, immediately after, and 48 h following left and right myocardial RF ablation procedures.Methods: The subjects were two groups of patients who underwent right-heart (24 patients) and left-heart (20 patients) RF ablation. Blood samples taken before, immediately after, and 48 h after the procedure were tested for changes in platelet and hemostatic activation.Results: No indication of clinically symptomatic thromboembolism and no major differences in baseline characteristics and procedure were apparent in either group, except for a higher temperature mode setting (p < 0.001) in the left-heart group. The hemostatic evaluation levels increased significantly by the end of the procedure in both groups and the platelet activation level remained elevated for 48 h after the procedure. The platelet activation level increased insignificantly at the end and 48 h after the procedure. Of the other changes in levels of platelet and hemostatic activation, only an increase in one of the hemostatic levels in the right-heart group at 48 h after procedure was significant (p = 0.01).

show abstract

“…T0 before insertion of sheaths, T1 end of EPS, T2 30 min after completion of RFA, DD D-dimers, TAT thrombin-antithrombin III, PAI-1 plasminogen activator inhibitor type 1, t-PA tissue-type plasminogen activator, CPAi circulating platelet aggregates index, LCL lower confidence level, UCL upper confidence level Potential mechanisms of thrombogenesis during ablation procedures are multiple and include endothelial disruption, coagulation necrosis, electroporation injury, mechanical damage of the vessel wall, and heating of circulating blood elements by RF energy [9][10][11][12][13][14][15][16][17][18]. Sasano et al [19] concluded that the thrombogenesis caused by RFA has 2 phases; in the acute phase hemostasis activation occurs during placement of the catheters and in the delayed phase thrombogenesis is the result of endothelial damage caused by the RF current.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic changes before and during electrophysiologic study and radiofrequency catheter ablation

Pařízek¹,

Haman²,

Pleskot³

et al. 2011

Int J Hematol

View full text Add to dashboard Cite

We sought to investigate specific hemostasis activation markers during electrophysiologic study (EPS) with consequent radiofrequency catheter ablation (RFA). Sixty patients were studied prospectively during routine EPS with RFA for paroxysmal supraventricular tachycardia. Blood samples were drawn before the insertion of venous sheaths (T0), at the end of EPS (T1), and 30 min after completion of RFA (T2). To study coagulation and fibrinolytic and platelet activity, we measured concentrations of thrombin-antithrombin III (TAT), D-dimers (DD), plasminogen activator inhibitor type 1 (PAI-1), tissue-type plasminogen activator (t-PA), and circulating platelet aggregates. The results are expressed as median and show 95% confidence levels. Levels of DD increased from 0.24 mg/L at T0 to 0.37 mg/L at T1 (P < 0.001) and to 0.59 mg/L at T2 (P < 0.001). TAT levels increased from 5.29 μg/L at T0 to 35.80 μg/L at T1 (P < 0.001) and decreased to 26.30 μg/L at T2 (P < 0.001). PAI-1 concentration decreased from 30.10 μg/L at T0 to 26.4 μg/L at T1 (P < 0.001). t-PA at T2 increased to 5.10 μg/L from 4.75 μg/L at T1 (P = 0.001). No other differences between corresponding medians were statistically significant (P > 0.05). We found that concentrations of DD at T2 versus T1 depended on the number of radiofrequency energy applications (r (S) = 0.387; P = 0.002). Marked platelet activation was observed from the start of the procedure, without changes during the procedure.

show abstract

Delayed Thrombogenesis Following Radiofrequency Catheter Ablation.

Cited by 13 publications

References 27 publications

Clinical Study of the Efficacy of a Cooled-Tip Catheter Ablation System for Common Atrial Flutter

Clinical Study of the Efficacy of a Cooled-Tip Catheter Ablation System for Common Atrial Flutter

Comparison of hemostatic activation created by right‐ and left‐heart radiofrequency catheter ablation

Hemostatic changes before and during electrophysiologic study and radiofrequency catheter ablation

Contact Info

Product

Resources

About