Delayed-Type Hypersensitivity to Fragrance Materials in a Select North American Population

“…Among eczema patients in Europe 1.5–3% give a positive patch test to HICC (1–4). Recently, similar frequencies of sensitization were found in a multi‐centre study in Korea (5), while it seems to be a less frequent fragrance allergen among eczema patients in North America (6).…”

mentioning

confidence: 67%

Experimental elicitation with hydroxyisohexyl‐3‐cyclohexene carboxaldehyde‐containing deodorants

Jørgensen

Jensen

Rastogi³

et al. 2007

Contact Dermatitis

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Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral is a frequent allergen. It is used in more than 50% of marketed deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15 patients with previously diagnosed contact allergy to HICC were patch tested with 5 solutions of HICC-scented and HICC-unscented deodorants. Patients and 10 healthy controls performed a use test in the axillae using deodorants scented with HICC in increasing concentrations and unscented deodorants as control. The concentration of HICC was increased every second week (200, 600, and 1800 p.p.m.) until either a reaction developed or for 6 weeks. 14 patients completed the study, and all developed unilateral eczema from the HICC-containing deodorant, while controls were all negative (P= 0.004). In 9/14 patients, a positive use test developed during the first 2 weeks to the deodorant containing 200 p.p.m. HICC. Positive correlations were found between the day of positive use and patch test threshold concentration of the HICC solutions (r= 0.71, P= 0.01) as well as the patch test thresholds of the HICC-scented deodorants (r= 0.74, P= 0.007). In conclusion, HICC elicits allergic contact dermatitis in a high proportion of sensitized individuals at common usage concentrations in deodorants.

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“…11,12 Specific inquiries about topical therapies are essential, because a substantial number of patients have contact allergies to preparations containing balsam of Peru, neomycin, bacitracin, and other common ingredients. [13][14][15][16] The resultant delayed hypersensitivity reactions can retard healing. 17 Additionally, many commonly used topical antiseptics are directly toxic to human cells.…”

Section: Medicationsmentioning

confidence: 99%