Delayed-Type Hypersensitivity Underlying Casein Allergy Is Suppressed by Extracellular Vesicles Carrying miRNA-150

Wąsik, Magdalena; Nazimek, Katarzyna; Nowak, Bernadeta; Askenase, P. W.; Bryniarski, Krzysztof

doi:10.3390/nu11040907

Cited by 28 publications

(62 citation statements)

References 38 publications

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“…Then, Ts cell‐derived EVs carrying miRNA‐150, additionally coated with hapten‐specific LCs, were shown to suppress the hapten‐induced CHS reaction antigen‐specifically in vivo (Figure 2). 139,148 Recently, we have found that an analogous tolerance mechanism could be induced in DTH to ovalbumin and bovine casein administered without an adjuvant 150 . The antigen‐specificity of the observed mechanism of DTH suppression by miRNA‐150‐carrying EVs was proved by testing of EVs mediating tolerance to keyhole limpet haemocyanin in active, ovalbumin‐induced DTH, 151 and of ovalbumin‐specific EVs in casein‐induced DTH 150 .…”

Section: The Apc‐ev‐mirna‐150 Circuit In the Regulation Of Dth To Selmentioning

confidence: 99%

“… 139,148 Recently, we have found that an analogous tolerance mechanism could be induced in DTH to ovalbumin and bovine casein administered without an adjuvant 150 . The antigen‐specificity of the observed mechanism of DTH suppression by miRNA‐150‐carrying EVs was proved by testing of EVs mediating tolerance to keyhole limpet haemocyanin in active, ovalbumin‐induced DTH, 151 and of ovalbumin‐specific EVs in casein‐induced DTH 150 . Interestingly, suppressed DTH reaction was observed in mice treated with Ts cell‐derived EVs administered via intraperitoneal, intravenous, intradermal or even oral routes 150 .…”

Section: The Apc‐ev‐mirna‐150 Circuit In the Regulation Of Dth To Selmentioning

confidence: 99%

“…The antigen‐specificity of the observed mechanism of DTH suppression by miRNA‐150‐carrying EVs was proved by testing of EVs mediating tolerance to keyhole limpet haemocyanin in active, ovalbumin‐induced DTH, 151 and of ovalbumin‐specific EVs in casein‐induced DTH 150 . Interestingly, suppressed DTH reaction was observed in mice treated with Ts cell‐derived EVs administered via intraperitoneal, intravenous, intradermal or even oral routes 150 . The highest therapeutic effect was achieved after oral administration of EVs, which greatly supports the eventual application of oral route of treatment with EVs to clinical practice.…”

Section: The Apc‐ev‐mirna‐150 Circuit In the Regulation Of Dth To Selmentioning

confidence: 99%

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Approaches to inducing antigen‐specific immune tolerance in allergy and autoimmunity: Focus on antigen‐presenting cells and extracellular vesicles

Nazimek

Bryniarski

2020

Scand J Immunol

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Increasing prevalence of allergic and autoimmune diseases urges clinicians and researchers to search for new and efficient treatments. Strategies that activate antigen-specific immune tolerance and simultaneously maintain immune reactivity to all other antigens deserve special attention. Accordingly, antigen-presenting cells (APCs) seem to be the best suited for orchestrating these mechanisms by directing T cell immune responses towards a tolerant subtype. Recent advances in understanding cell-to-cell communication via extracellular vesicles (EVs) make the latter promising candidates for reprogramming APCs towards a tolerant phenotype, and for mediating tolerogenic APC function. Thus, comprehensive studies have been undertaken to describe the interactions of APCs and EVs naturally occurring during immune tolerance induction, as well as to develop EV-based manoeuvres enabling the induction of immune tolerance in an antigen-specific manner. In this review, we summarize the findings of relevant studies, with a special emphasis on future perspectives on their translation to clinical practice.

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Section: The Apc‐ev‐mirna‐150 Circuit In the Regulation Of Dth To Selmentioning

confidence: 99%

Section: The Apc‐ev‐mirna‐150 Circuit In the Regulation Of Dth To Selmentioning

confidence: 99%

Section: The Apc‐ev‐mirna‐150 Circuit In the Regulation Of Dth To Selmentioning

confidence: 99%

See 1 more Smart Citation

Approaches to inducing antigen‐specific immune tolerance in allergy and autoimmunity: Focus on antigen‐presenting cells and extracellular vesicles

Nazimek

Bryniarski

2020

Scand J Immunol

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“…Most food allergies manifest in two general forms based on the time of appearance of clinical symptoms after exposure and the underlying immune mechanisms involved in eliciting them [3,4,82]. They are: (i) immediate (or Type I or IgE antibody-mediated) hypersensitivity reactions, where symptoms appear within minutes to 3 h; and (ii) delayed (or Type IV or cell mediated) hypersensitivity reactions, where symptoms of reaction appear after 48-72 h of exposure to the food allergens [83,84]. Most food allergies are of the Type I nature.…”

Section: Pathogenesis Of Sesame Allergy: Gaps In the Cellular And Molmentioning

confidence: 99%

“…Most food allergies are of the Type I nature. However, some food allergies such as milk allergies can involve both Type I and Type IV reactions [84].…”

Section: Pathogenesis Of Sesame Allergy: Gaps In the Cellular And Molmentioning

confidence: 99%

The Global Rise and the Complexity of Sesame Allergy: Prime Time to Regulate Sesame in the United States of America?

Gangur

Acharya

2020

Allergies

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Sesame allergy is a life-threatening disease that has been growing globally with poorly understood mechanisms. To protect sensitive consumers, sesame is regulated in many countries. There were four research goals for this work on sesame allergy: (i) to map the timeline, and the extent of its global rise; (ii) to dissect the complexity of the disease, and its mechanisms; (iii) to analyze the global regulation of sesame; and (iv) to map the directions for future research and regulation. We performed a literature search on PubMed and Google Scholar, using combinations of key words and analyzed the output. Regulatory information was obtained from the government agencies. Information relevant to the above goals was used to make interpretations. We found that: (i) the reports appeared first in 1950s, and then rapidly rose globally from 1990s; (ii) sesame contains protein and lipid allergens, a unique feature not found in other allergenic foods; (iii) it is linked to five types of diseases with understudied mechanisms; and (iv) it is a regulated allergen in 32 advanced countries excluding the USA. We also provide directions for filling gaps in the research and identify implications of possible regulation of sesame in the USA.

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COVID‐19 therapy with mesenchymal stromal cells (MSC) and convalescent plasma must consider exosome involvement: Do the exosomes in convalescent plasma antagonize the weak immune antibodies?

Askenase

2020

J of Extracellular Vesicle

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Exosome extracellular vesicles as biologic therapy for COVID‐19 are discussed for two areas. The first involves the growing use of mesenchymal stromal cells (MSCs) for the profound clinical cytokine storm and severe pneumonia in COVID‐19 patients. Instead, it is recommended to treat alternatively with their MSC‐released exosomes. This is because many reports in the literature and our data have shown that the release of exosomes from the in vivo administered MSC is actually responsible for their beneficial effects. Further, the exosomes are superior, simpler and clinically more convenient compared to their parental MSC. Additionally, in the context of COVID‐19, the known tendency of MSC to intravascularly aggregate causing lung dysfunction might synergize with the pneumonia aspects, and the tendency of MSC peripheral vascular micro aggregates might synergize with the vascular clots of the COVID‐19 disease process, causing significant central or peripheral vascular insufficiency. The second exosome therapeutic area for severe COVID‐19 involves use of convalescent plasma for its content of acquired immune antibodies that must consider the role in this therapy of contained nearly trillions of exosomes. Many of these derive from activated immune modulating cells and likely can function to transfer miRNAs that acting epigenetically to also influence the convalescent plasma recipient response to the virus. There is sufficient evidence, like recovery of patients with antibody deficiencies, to postulate that the antibodies actually have little effect and that immune resistance is principally due to T cell mechanisms. Further, COVID‐19 convalescent plasma has remarkably weak beneficial effects if compared to what was expected from many prior studies. This may be due to the dysfunctional immune response to the infection and resulting weak Ab that may be impaired further by antagonistic exosomes in the convalescent plasma. At the least, pre selection of plasma for the best antibodies and relevant exosomes would produce the most optimum therapy for very severely affected COVID‐19 patients.

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Delayed-Type Hypersensitivity Underlying Casein Allergy Is Suppressed by Extracellular Vesicles Carrying miRNA-150

Cited by 28 publications

References 38 publications

Approaches to inducing antigen‐specific immune tolerance in allergy and autoimmunity: Focus on antigen‐presenting cells and extracellular vesicles

Approaches to inducing antigen‐specific immune tolerance in allergy and autoimmunity: Focus on antigen‐presenting cells and extracellular vesicles

The Global Rise and the Complexity of Sesame Allergy: Prime Time to Regulate Sesame in the United States of America?

COVID‐19 therapy with mesenchymal stromal cells (MSC) and convalescent plasma must consider exosome involvement: Do the exosomes in convalescent plasma antagonize the weak immune antibodies?

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