Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder

Ross, Brian M.; Ward, P.E.; Glen, Iain

doi:10.1016/j.jad.2003.11.005

Cited by 18 publications

(10 citation statements)

References 34 publications

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“…Serum was then separated by centrifugation (10 min at 3000g) and immediately stored in 1 ml aliquots at − 35°C. In contrast to membrane fatty acids and phospholipids Ross et al, 2004), follow-up measures to investigate stability of PLA 2 activity over time showed stability of quantitative analyses of enzyme activity for up to 5 years after blood sampling, if aliquots were stored continuously at − 35°C, and provided that the thawed sera were re-centrifuged and stirred carefully in order to avoid any inhomogeneities of the specimen (Lasch et al, 2003). In this study, blood was taken right before the VBM investigation in most cases; in those cases with a time lag between MRI and blood sampling this did not exceed 2 days and is therefore not likely to have influenced results.…”

Section: Acquiring and Storage Of Blood Samplesmentioning

confidence: 99%

Phospholipase A2 activity is associated with structural brain changes in schizophrenia

et al. 2010

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Section: Acquiring and Storage Of Blood Samplesmentioning

confidence: 99%

Phospholipase A2 activity is associated with structural brain changes in schizophrenia

et al. 2010

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“…Thus far, studies in this area have focused on specific nutrients and not on the diet as a whole. These types of studies suggest that the protective effect of fish consumption on depression is most likely explained by the long chain n-3 polyunsaturated fatty acids (PUFAs) present in fish (Sontrop & Campbell 2006;Perica & Delas 2011), which are thought to modulate serotonergic neurotransmission (Ross et al 2004). Furthermore, patients with depression often have low circulating levels of n-3 PUFAs (Sontrop & Campbell 2006).…”

Section: Food Intake Nutrient Status and Depressionmentioning

confidence: 99%

The MooDFOOD project: Prevention of depression through nutritional strategies

2017

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MooDFOOD is a 'Multi-country cOllaborative project on the rOle of Diet, Food-related behaviour, and Obesity in the prevention of Depression'. Depression is one of the most prevalent, severe and disabling disorders in the European Union (EU) and places a heavy burden on individuals and families. A large proportion of the EU population is overweight, which increases depression risk. Targeting food-related behaviours and nutritional status of people prone to overweight and obesity offers opportunities to prevent depression. The MooDFOOD consortium combines expertise in nutrition, consumer behaviour, psychiatry and preventive health psychology and uses a unique integrative approach. Existing high quality data from longitudinal prospective European cohort studies will be combined with new data from surveys, short-term experiments and a long-term preventive intervention study. This approach will provide insight into the causality of the link between diet and depression, and underlying pathways; it will also identify which modifications related to diet and dietary behaviour lead to beneficial changes in depression risk and lower the environmental burden of the diet. Knowledge of all these aspects will be used to develop novel nutritional strategies to prevent depression. In close collaboration with stakeholders and experts, MooDFOOD will transform the identified nutritional strategies into guidelines and practical tools to guide policy at EU and Member State levels. Promotion of the findings through extensive European networks will help to lower the risk of depression and contribute to overall health of all EU citizens.

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“…An antidepressant role of ω‐3 PUFAs is biologically plausible with a modulation of serotonergic neurotransmission, the target system of SSRI antidepressants, being one possible mechanism. 44 , 45 The simplest explanation for the efficacy of ω‐3 PUFA in MDD, supported by observational studies, is that patients with the disorder are deficient in this class of fatty acids 46 . Moreover, reduced ω‐3 PUFA levels in MDD are due to abnormal activity of the ω‐3 PUFA uptake mechanism.…”

Section: Metabolism Of Essential Fatty Acidsmentioning

confidence: 99%

Essential Fatty Acids and Psychiatric Disorders

Perica

Delaš

2011

Nut in Clin Prac

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Psychiatric disorders are a significant source of disability worldwide. Increasing evidence indicates that disturbances of fatty acids and phospholipid metabolism can play a part in a wide range of psychiatric, neurological, and developmental disorders in adults. Essential fatty acids, ω-3 and ω-6 polyunsaturated fatty acids, play a central role in the normal development and functioning of the brain and central nervous system. The aim of this article is to discuss the overall insight into roles of essential fatty acids in the development of mental disorders (depression, schizophrenia, bipolar disorder) and, in light of the fact that disturbances of fatty acid metabolism can play a part in the above-mentioned disorders, to investigate the current knowledge of lipid abnormalities in posttraumatic stress disorder. The information in this review was obtained after extensive MEDLINE searching of each topic area through relevant published studies from the past 20 years. References from the obtained studies were also used. This review summarizes the knowledge in terms of essential fatty acids intake and metabolism, as well as evidence pointing to potential mechanisms of essential fatty acids in normal brain functioning and development of neuropsychiatric disorders. The literature shows that ω-3 fatty acids provide numerous health benefits and that changes in their concentration in organisms are connected to a variety of psychiatric symptoms and disorders, including stress, anxiety, cognitive impairment, mood disorders, and schizophrenia. Further studies are necessary to confirm ω-3 fatty acids' supplementation as a potential rational treatment in psychiatric disorders.

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Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder

Cited by 18 publications

References 34 publications

Phospholipase A2 activity is associated with structural brain changes in schizophrenia

Phospholipase A2 activity is associated with structural brain changes in schizophrenia

The MooDFOOD project: Prevention of depression through nutritional strategies

Essential Fatty Acids and Psychiatric Disorders

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