Delayed Wound Healing in Leukocyte Adhesion Deficiency Type 1

Wada, Taizo; Tone, Yumi; Shibata, Fumie; Toma, Tomoko; Yachie, Akihiro

doi:10.1016/j.jpeds.2010.07.057

Cited by 11 publications

(10 citation statements)

References 4 publications

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“…It has already been suggested for decades that neutrophils play an important role in tissue repair. Most of the data supportive for this hypothesis are circumstantial, but nevertheless the findings in mouse models and small children with leucocyte adhesion deficiency types I, II and III clearly show impaired tissue repair responses associated with the absence of neutrophils in the tissues and marked neutrophilia in blood and bone marrow . These data imply that the absence of neutrophils in the tissues due to aberrant homing leads to impaired tissue repair by as yet unidentified mechanisms.…”

Section: The Neutrophil In Tissue Regeneration and Repairmentioning

confidence: 95%

“…However, an increasing number of clinical conditions are found to be at least in part mediated by malfunctioning of these cells. Apart from the already mentioned pro‐tumorigenic action of certain neutrophil phenotypes, other diseases are mediated by both hyper‐ and hypo‐activity of these cells …”

Section: The Neutrophil In Aberrant Pro‐ and Anti‐inflammatory Conditmentioning

confidence: 99%

“…Apart from the already mentioned pro-tumorigenic action of certain neutrophil phenotypes, other diseases are mediated by both hyper-and hypo-activity of these cells. 49,[57][58][59][60] 7.1 | Diseases associated with hyperactivation of neutrophil phenotypes chronic inflammatory diseases (eg cystic fibrosis, chronic obstructive pulmonary disease), acute inflammation (systemic inflammatory response syndrome, acute respiratory distress syndrome, multi-organ dysfunction) and reperfusion injury. [61][62][63][64] These conditions have in common that neutrophil-driven tissue damage is a hall mark of the disease, and it is imperative that neutrophil responses responsible should be inhibited with future innovative treatments.…”

Section: The Neutrophil In Aberrant Pro-and Anti-inflammatory Condimentioning

confidence: 99%

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Neutrophil phenotypes in health and disease

Hellebrekers

Vrisekoop

Koenderman

2018

Eur J Clin Investigation

101

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Neutrophils are one of the most important effector cells of the innate immune response (1). They are traditionally seen as a homogenous population of short‐lived cells mainly involved in the defence against extracellular microorganisms by phagocytosis and intracellular killing (1,2). The cells contain a large armamentarium that aids in this function and ranges from the production of reactive oxygen species by a membrane‐bound NADPH oxidase to cytotoxic proteins and peptides residing in the different granules present in the cytoplasm (3). Recently, the view of neutrophils belonging to a homogenous population of cells has been challenged, and several neutrophil phenotypes have been described that exhibit specialized functions, such as involvement in tissue repair, tumour killing and immune regulation (4). It is not clear whether these cells belong to separate parallel lineages originating from the bone marrow or that neutrophils become instructed in the distant tissues, thus changing their phenotypes. In addition, functional heterogeneity in a phenotypically homogenous population of neutrophils adds to the complexity of neutrophil phenotypes(5). This article will review the current literature describing the heterogeneity within the neutrophil compartment with respect to both phenotype and function in health and disease.

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Section: The Neutrophil In Tissue Regeneration and Repairmentioning

confidence: 95%

Section: The Neutrophil In Aberrant Pro‐ and Anti‐inflammatory Conditmentioning

confidence: 99%

Section: The Neutrophil In Aberrant Pro-and Anti-inflammatory Condimentioning

confidence: 99%

See 1 more Smart Citation

Neutrophil phenotypes in health and disease

Hellebrekers

Vrisekoop

Koenderman

2018

Eur J Clin Investigation

101

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“…They play a critical role in promoting recovery after surgery by facilitating the healing of surgical incisions and anastomoses and by mediating the host-defense response against invading pathogens (1-4). As such, leukocyte depletion or dysfunction is associated with delayed surgical wound healing, increased rates of postoperative infection, and poor overall outcomes following surgery (5-7). For these reasons, surgeons may defer operating on leukopenic patients until the underlying cause of the leukopenia can be addressed and leukocyte counts can be restored.…”

Section: Introductionmentioning

confidence: 99%

Leukopenia is associated with worse but not prohibitive outcomes following emergent abdominal surgery

Gulack

Englum

et al. 2015

Journal of Trauma and Acute Care Surgery

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Introduction There is little data currently available to guide surgical decision making regarding emergent surgical interventions in leukopenic patients. The purpose of this study was to investigate the impact of leukopenia among patients undergoing emergency abdominal operations in order to better guide preoperative decision making. Methods The 2005-2012 American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried to identify patients who underwent emergent laparotomy. Patients were stratified by pre-operative white blood cell (WBC) count (<4.0 × 109/L vs 4.0-12.0 × 109/L). Baseline demographics, comorbidities, and outcomes were compared. Multivariable logistic regression was performed to estimate the adjusted association between leukopenia and mortality taking into account the robust array of patient-related factors. Results Of the 20,443 patients who met study criteria, 2,057 (8.2%) were leukopenic (WBC <4.0) prior to surgery. Unadjusted comparison demonstrated significantly increased major morbidity (45.4% vs 26.9%, p<0.001) as well as mortality (24.4% vs 10.8%, p<0.001) for patients with leukopenia compared to patients with a normal preoperative WBC count. Only 46.0% (n=947) of patients with leukopenia prior to surgery were able to avoid major morbidity or mortality compared to 69.4% (n=15,974) of patients with a normal preoperative WBC count (p<0.001). After multivariable adjustment for patient-related factors, leukopenia was maintained as a significant predictor of mortality. Conclusions Although leukopenia remains associated with mortality in patients undergoing emergent laparotomy despite adjustment for other patient-related factors, it is not necessarily prohibitive. Understanding the risk of complications and mortality associated with these procedures is pertinent for pre-operative clinical decision making. Level of Evidence Level III, Prognostic and Epidemiological Study.

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“…Hip X-ray shows the deformity of the right femoral head (black arrows). 터 발생하며 가장 흔히 처음 겪게 되는 감염은 제대 탈락의 지연으로 인한 배꼽염(omphalitis)이다 1,2,9) . [14][15][16] .…”

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Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant

Kim

Chung

et al. 2018

Neonatal Med

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Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the gene encoding CD18, which is a con stituent of leukocyte integrins. Clinical features usually begin with a delay in the sepa ration of the umbilical cord in the neonatal period, and are characterized by marked leukocytosis with infection, delayed wound healing, and repeated bacterial and fungal infections. We experienced a case of leukocyte adhesion deficiency dia gnosed in the neonatal period, in which a late preterm infant admitted to neonatal intensive care unit presented with a septic hip. Flow cytometry analysis of whole blood showed a decrease in the expression of CD11b/CD18. This is the first case of leukocyte adhesion deficiency with neonatal septic hip diagnosed in Korea.

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Delayed Wound Healing in Leukocyte Adhesion Deficiency Type 1

Cited by 11 publications

References 4 publications

Neutrophil phenotypes in health and disease

Neutrophil phenotypes in health and disease

Leukopenia is associated with worse but not prohibitive outcomes following emergent abdominal surgery

Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant

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