Delays in the Publication of Important Clinical Trial Findings in Oncology

Qunaj, Lindor; Jain, Raina H; Atoria, Coral L.; Gennarelli, Renee L.; Miller, Jennifer E.

doi:10.1001/jamaoncol.2018.0264

Cited by 35 publications

(29 citation statements)

References 35 publications

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“…the results of many clinical trials are never reported or only reported years after trial completion 123. Delays in publication can cause harm as scientists work without knowing what others have done or found 45. Moreover, for public health emergencies, when rapid communication is essential, preprint servers can immediately disseminate study findings globally, fostering scientific exchange 6…”

Section: Yes—harlan M Krumholz Joseph S Rossmentioning

confidence: 99%

Will research preprints improve healthcare for patients?

Krumholz

Ross

Otto

2018

BMJ

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Section: Yes—harlan M Krumholz Joseph S Rossmentioning

confidence: 99%

Will research preprints improve healthcare for patients?

Krumholz

Ross

Otto

2018

BMJ

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show abstract

“…This criticism of publication delays may be well-founded. For example, a recent study in JAMA Oncology found that results from phase III oncology trials have a median time to publication of 350 days and even longer if reporting negative findings [3]. While such delays may negatively affect patients, scientists may suffer as well.…”

Section: Introductionmentioning

confidence: 99%

When will I get my paper back? A replication study of publication timelines for health professions education research

Maggio¹,

Bynum²,

Schreiber-Gregory³

et al. 2020

Perspect Med Educ

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Introduction Biomedical researchers have lamented the lengthy timelines from manuscript submission to publication and highlighted potential detrimental effects on scientific progress and scientists' careers. In 2015, Himmelstein identified the mean time from manuscript submission to acceptance in biomedicine as approximately 100 days. The length of publication timelines in health professions education (HPE) is currently unknown. Methods This study replicates Himmelstein's work with a sample of 14 HPE journals published between 2008-2018. Using PubMed, 19,182 article citations were retrieved. Open metadata for each were downloaded, including the date the article was received by the journal, date the authors resubmitted revisions, date the journal accepted the article, and date of entry into PubMed. Journals without publication history metadata were excluded. Results Publication history data were available for 55% (n = 8) of the journals sampled. The publication histories of 4,735 (25%) articles were analyzed. Mean time from: (1) author submission to journal acceptance was 180.93 days (SD = 103.89), (2) author submission to posting on PubMed was 263.55 days (SD = 157.61), and (3) journal acceptance to posting on PubMed was 83.15 days (SD = 135.72). Discussion This study presents publication metadata for journals that openly provide it-a first step towards understanding publication timelines in HPE. Findings confirm the replicability of the original study, and the limited data suggest that, in comparison to biomedical scientists broadly, medical educators may experience longer wait times for article acceptance and publication. Reasons for these delays are currently unknown and deserve further study; such work would be facilitated by increased public access to journal metadata.

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“…This criticism of publication delays may be well-founded. For example, a recent study in JAMA Oncology found that results from Phase III oncology trials have a median time to publication of 350 days and even longer if reporting negative findings [3].…”

Section: What This Article Addsmentioning

confidence: 99%

When will I get my paper back? A replication study of publication timelines for health professions education research

Maggio

Bynum

Schreiber-Gregory

et al. 2019

Preprint

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Biomedical researchers have lamented the lengthy timelines from manuscript submission to publication and highlighted potential detrimental effects on scientific progress and scientists’ careers. In 2015, Himmelstein identified the mean time from manuscript submission to acceptance in biomedicine as approximately 100 days. The length of publication timelines in health professions education (HPE) is currently unknown.This study replicates Himmelstein’s work with a sample of 14 HPE journals published between 2008-2018. Using PubMed, 19,182 article citations were retrieved. Open metadata for each was downloaded, including the date the article was received by the journal, the date the authors resubmitted revisions, the date the journal accepted the article, and date of entry into PubMed. Journals without publication history metadata were excluded.Publication history data was available for 55% (n=8) of the journals sampled. The publication histories of 4,735 (25%) articles were analyzed. Mean time from: (1) author submission to journal acceptance was 180.93 days (SD=103.89), (2) author submission to posting on PubMed was 263.55 days (SD=157.61), and (3) journal acceptance to posting on PubMed was 83.15 days (SD=135.72).This study presents publication metadata for journals that openly provide it—a first step towards understanding publication timelines in HPE. Findings confirm the replicability of the original study, and the limited data suggest that, in comparison to biomedical scientists broadly, medical educators may experience longer wait times for article acceptance and publication. Reasons for these delays are currently unknown and deserve further study; such work would be facilitated by increased public access to journal metadata.What this article addsPublication delays can negatively impact science and researchers’ careers. A previous study, in biomedicine, leveraged publicly available data to identify a 100-day waiting period between manuscript submission and acceptance. However, this study provides limited information on timelines for health professions education (HPE) articles. Thus, the current study replicates the original investigation with publication timeline data for eight HPE journals, which make their data publicly accessible, finding the mean time from submission to acceptance to be 181 days. Reasons for these delays are currently unknown and deserve further study; such work would be facilitated by increased public access to journal metadata.

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Delays in the Publication of Important Clinical Trial Findings in Oncology

Abstract: Even for the most pressing study findings, median publication delays approach 1 year. As publication delays hinder research progress and advancements in clinical care, policies that enable early preprint release or public posting of completed data analysis should be pursued.

Cited by 35 publications

References 35 publications

Will research preprints improve healthcare for patients?

Will research preprints improve healthcare for patients?

When will I get my paper back? A replication study of publication timelines for health professions education research

When will I get my paper back? A replication study of publication timelines for health professions education research

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Delays in the Publication of Important Clinical Trial Findings in Oncology

Abstract: Even for the most pressing study findings, median publication delays approach 1 year. As publication delays hinder research progress and advancements in clinical care, policies that enable early preprint release or public posting of completed data analysis should be pursued.

Cited by 35 publications

References 35 publications

Will research preprints improve healthcare for patients?

Will research preprints improve healthcare for patients?

When will I&nbsp;get my paper back? A&nbsp;replication study of publication timelines for health professions education research

When will I get my paper back? A replication study of publication timelines for health professions education research

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When will I get my paper back? A replication study of publication timelines for health professions education research