Deleterious Effect of <i>p</i>-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites

Wong, Ximena; Carrasco‐Pozo, Catalina; Escobar, Elizabeth; Navarrete, Paola; Blachier, Franςois; Andriamihaja, Mireille; Lan, Annaïg; Tomé, Daniel; Cires, Marı́a José; Pastene, Edgar; Gotteland, Martín

doi:10.1021/acs.jafc.6b00656

Cited by 62 publications

(52 citation statements)

References 53 publications

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“…In Caco-2 cells, all extracts and bacterial metabolites prevented the p-cresol-induced alterations of barrier function (measured as transepithelial electrical resistance and fluorescein-dextran transport). These results suggest that PAC-containing polyphenol extracts and PAC metabolites likely contribute to the protection of the colonic mucosa against the deleterious effects of p-cresol (207). …”

Section: The Pacs In the Colonmentioning

confidence: 91%

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

et al. 2017

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Proanthocyanidins (PACs) are polymers of flavan-3-ols abundant in many vegetable foods and beverages widely consumed in the human diet. There is increasing evidence supporting the beneficial impact of dietary PACs in the prevention and nutritional management of non-communicable chronic diseases. It is considered that PACs with a degree of polymerization >3 remain unabsorbed in the gastrointestinal (GI) tract and accumulate in the colonic lumen. Accordingly, the GI tract may be considered as a key organ for the healthy-promoting effects of dietary PACs. PACs form non-specific complexes with salivary proteins in mouth, originating the sensation of astringency, and with dietary proteins, pancreatic enzymes, and nutrient transporters in the intestinal lumen, decreasing the digestion and absorption of carbohydrates, proteins, and lipids. They also exert antimicrobial activities, interfering with cariogenic or ulcerogenic pathogens in the mouth (Streptococcus mutans) and stomach (Helicobacter pylori), respectively. Through their antioxidant and antiinflammatory properties, PACs decrease inflammatory processes in animal model of gastric and colonic inflammation. Interestingly, they exert prebiotic activities, stimulating the growth of Lactobacillus spp. and Bifidobacterium spp. as well as some butyrate-producing bacteria in the colon. Finally, PACs are also metabolized by the gut microbiota, producing metabolites, mainly aromatic acids and valerolactones, which accumulate in the colon and/or are absorbed into the bloodstream. Accordingly, these compounds could display biological activities on the colonic epithelium or in extra-intestinal tissues and, therefore, contribute to part of the beneficial effects of dietary PACs.

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Section: The Pacs In the Colonmentioning

confidence: 91%

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

et al. 2017

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“…a). The most common compounds present in peel extracts are organic acids, hydroxybenzoic and hydroxycinnamic acid derivatives, flavonoids, (epi)catechin derivatives, proanthocyanidins and procyanidins at different degrees of polymerisation (Kosińska et al ., ; Morais et al ., ; Calderón‐Oliver et al ., ; López‐Cobo et al ., ; Wong et al ., ; Saavedra et al ., ; Figueroa et al ., ; Melgar et al ., ; Tremocoldi et al ., ). Not only avocado variety and extraction solvents, but also light exposure, temperature, pH, oxygen and enzymatic activities are factors affecting the concentration and stability (Rawson et al ., ) of these substances.…”

Section: Avocado Peelmentioning

confidence: 97%

“…Fresh peel composition consists of carbohydrates (62–73.3%), proteins (4–8.3%), lipids (4.4–9.1%), fibres (about 50%) and ashes (4–6.1%) (Domínguez et al ., ). Peel is also rich in polyphenols, traditionally extracted by maceration of dried material using boiling water (Calderón‐Oliver et al ., ; Wong et al ., ) or mixture of solvents: acetone/water (Saavedra et al ., ) or ethanol/water (Melgar et al ., ; Tremocoldi et al ., ); however, other less conventional methods are also proposed, that is, ultrasonic (López‐Cobo et al ., ) or pressurised liquid extractions (Rodríguez‐Carpena et al ., ). Among them an accelerated solvent extraction has the great advantage of using generally recognised as safe (GRAS) solvents.…”

Section: Avocado Peelmentioning

confidence: 99%

Avocado (Persea americana Mill.) by‐products and their impact: from bioactive compounds to biomass energy and sorbent material for removing contaminants. A review

Colombo

Papetti

2019

Int J of Food Sci Tech

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Avocado industry produces enormous by-products and represents an important source of raw material in food and non-food applications. This review aims to focus the attention on the valorisation of avocado wastes recycling to produce different materials with important industrial and environmental impacts. In fact, peels and seeds can be reused in food and cosmetic fields due to the presence of bioactive ingredients such as polyphenols; thanks to their antioxidant and antinflammatory activities. In addition, both peels and seeds can be reused in the production of carbonaceous materials with important consequences for environmental pollution in the removal of contaminants from water. Interesting applications of avocado wastes in photocatalysis and biofuel production are also discussed. All the utilisations attest the great potential of recycling avocado by-products, a little known resource.

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“…One promising future strategy would be to rationally select the protein source, taking into account their AA profile and their digestibility in order to specifically promote the production of beneficial AA-derived metabolites. Conversely, the consumption of dietary unabsorbed or partially absorbed compounds able to bind deleterious bacterial metabolites in the colonic luminal content represents a promising strategy for diminishing their free luminal concentration [84,85] and thus their negative impact on the colonic mucosa.…”

Section: Potential Role Of Dietary Proteins In Inflammatory Flarementioning

confidence: 99%

Dietary Protein and Amino Acid Supplementation in Inflammatory Bowel Disease Course: What Impact on the Colonic Mucosa?

et al. 2017

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Inflammatory bowel diseases (IBD), after disease onset, typically progress in two cyclically repeated phases, namely inflammatory flare and remission, with possible nutritional status impairment. Some evidence, either from epidemiological, clinical, and experimental studies indicate that the quantity and the quality of dietary protein consumption and amino acid supplementation may differently influence the IBD course according to the disease phases. For instance, although the dietary protein needs for mucosal healing after an inflammatory episode remain undetermined, there is evidence that amino acids derived from dietary proteins display beneficial effects on this process, serving as building blocks for macromolecule synthesis in the wounded mucosal area, energy substrates, and/or precursors of bioactive metabolites. However, an excessive amount of dietary proteins may result in an increased intestinal production of potentially deleterious bacterial metabolites. This could possibly affect epithelial repair as several of these bacterial metabolites are known to inhibit colonic epithelial cell respiration, cell proliferation, and/or to affect barrier function. In this review, we present the available evidence about the impact of the amount of dietary proteins and supplementary amino acids on IBD onset and progression, with a focus on the effects reported in the colon.

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Deleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites

Cited by 62 publications

References 53 publications

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

Avocado (Persea americana Mill.) by‐products and their impact: from bioactive compounds to biomass energy and sorbent material for removing contaminants. A review

Dietary Protein and Amino Acid Supplementation in Inflammatory Bowel Disease Course: What Impact on the Colonic Mucosa?

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