Deleterious Effect of Smoking and Nasal Septal Deviation on Mucociliary Clearance and Improvement after Septoplasty

Abstract

Nasal septal deviation and smoking deteriorates nasal MCC time and this result can be shown easily with the saccharine test. Properly performed septoplasty surgery decreases nasal MCC time during the late postoperative period but MCC times are still longer than normal. The saccharine test can be used for following up the effect of septoplasty upon nasal mucosa.

Do Nasal Surgeries Affect Mucociliary Clearance?

“…They also found that there is no significant difference in mucociliary clearance time between obstructed nasal cavity and the non-obstructed side. In the study by Kamaran and Tek [6], the test side was selected randomly .Similarly in our study it was found that there was no significant difference in the mucociliary clearance between the obstructed and the non-obstructed sides.…”

“…In our study, patients showed improvement in the symptoms at the end of 6 weeks after surgery. There was a statistically significant decrease at the postoperative mucociliary clearance time among the non-smoker patients who underwent surgery when compared with preoperative mucociliary clearance time [6]. Kamaran and Tek concluded that if the septoplasty procedure is properly performed, nasal mucociliary clearance significantly improves.…”

“…Mucociliary clearance can be effected from environmental heat, moisture, partial oxygen pressure, pH, trauma, sulphur dioxide, formaldehyde, ozone, chlorine, smoking, viral infections, chronic sinusitis, chronic and allergic rhinitis, adenoid hypertrophy, cystic fibrosis, chronic bronchitis, septal deviation, surgery, bronchial asthma, and diabetes mellitus [6].…”

Chronic rhinosinusitis: Epidemiology and medical management

“…Active cigarette smoking is associated with a decrease in mucociliary clearance measured based on saccharine transit time 21 and has been shown to have a negative effect on mucosal recovery after endoscopic sinus surgery in adults and children. [22][23][24][25] In a study using the Third National Health and Nutrition Examination Survey (1988-1994) of 33,994 persons, Lieu and Feinstein 26 examined the relationship between chronic sinusitis, active cigarette smoking, and secondhand smoke (SHS) exposure.…”

Postoperative Findings in Endoscopic Endonasal Surgery of The Skull Base

“…In the first group we have primary (genetic) and secondary (infection or inflammation) ciliary diskinesia while in the second group we found cystic fibrosis, COPD, or asthma patients. Many factors influence the MCC, among them are: temperature, humidity, trauma, smoking, viral infections, chronic sinusitis, allergic rhinitis, adenoid hypertrophy, deviated septum, sinus surgery, fibrosis cystic, chronic bronchitis and asthma [23]. At present, none of the methods studying MCC is the ideal, and there is a variety of investigational methods and techniques for its study.…”