Deleterious effects of prenatal exposure to morphine on the spatial learning and hippocampal BDNF and long-term potentiation in juvenile rats: Beneficial influences of postnatal treadmill exercise and enriched environment

Ahmadalipour, Ali; Ghodrati-Jaldbakhan, Shahrbanoo; Samaei, Afshin; Rashidy-Pour, Ali

doi:10.1016/j.nlm.2017.11.013

Cited by 42 publications

(35 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Few studies have investigated the effect of paternal morphine exposure on hippocampal and cognitive function with the majority of this work focused on maternal or prenatal influences (Ahmadalipour et al 2018;Lin et al 2009;Nasiraei-Moghadam et al 2013;Sepehri et al 2014;Sithisarn et al 2011;Tan et al 2015;Yang et al 2006). Both maternal and paternal oral morphine administration caused impairments in passive avoidance memory in both male and female offspring (Akbarabadi et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring

et al. 2020

View full text Add to dashboard Cite

Rationale: Parental drug use around or before conception can have adverse consequences for offspring. Historically, this research has focused on the effects of maternal substance use on future generations but less is known about the influence of the paternal lineage. This study focused on the impact of chronic paternal morphine exposure prior to conception on behavioral outcomes in male and female progeny. Objectives: This study sought to investigate the impact of paternal morphine self-administration on anxiety-like behavior, the stress response, and memory in male and female offspring. Methods: Adult, drug-naïve male and female progeny of morphine-treated sires and controls were evaluated for anxiety-like behavior using defensive probe burying and novelty-induced hypophagia paradigms. Hypothalamic-pituitary-adrenal (HPA) axis function was assessed by measuring plasma corticosterone levels following a restraint stressor in male and female progeny. Memory was probed using a battery of tests including object location memory, novel object recognition and contextual fear conditioning. Results: Paternal morphine exposure did not alter anxiety-like behavior or stress-induced HPA axis activation in male or female offspring. Morphine-sired male and female offspring showed intact hippocampus-dependent memory: they performed normally on the long-term fear conditioning and object location memory tests. In contrast, paternal morphine exposure selectively disrupted novel object recognition in female, but not male progeny. Conclusions: Our findings demonstrate that paternal morphine taking produces sex-specific and selective impairments in object recognition memory while leaving hippocampal function largely intact.

show abstract

Section: Discussionmentioning

confidence: 99%

Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Bornavard et al (2020) demonstrated that morphine consumption during pregnancy reduced the brain BDNF level in pup of rats. Ahmadalipour et al (2018) observed that prenatal morphine exposure reduced the hippocampal BDNF levels and impaired the spatial learning in offspring of rats.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have revealed that opioid exposure during pregnancy in rodents leads to changes in BDNF and NGF levels in the brain of offspring, and thus, neurobehavioral defects (Ahmadalipour, Ghodrati‐Jaldbakhan, Samaei, & Rashidy‐Pour, 2018; Oliveira et al, 2017; Wu et al, 2014; Wu, Mo, Yabe, Schwartz, & Robinson, 2001).…”

Section: Introductionmentioning

confidence: 99%

Brain‐derived neurotrophic factor and nerve growth factor concentrations in maternal and umbilical cord blood of opium‐addicted mothers

Fanaei

Riki

Khayat

et al. 2020

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Background It is reported that opium consumption during pregnancy is associated with adverse pregnancy outcomes and neurodevelopmental defects in infants. BDNF and NGF alterations during pregnancy cause neurobehavioral deficits in the offspring. The aim of this study was to investigate the effect of opium addiction of pregnant women on BDNF and NGF levels in maternal and umbilical cord blood as well as pregnancy outcome. Materials and methods The present research was a cross‐sectional study. Thirty‐five addicted pregnant women and 35 healthy pregnant women were included in the study. Blood samples were taken immediately after delivery from the maternal vein and umbilical cord. Then, BDNF and NGF concentrations in serum were measured by ELISA kits. The outcomes of pregnancy were determined by a checklist. Descriptive, t test, Mann–Whitney, and Chi‐squared test were used to analyze the data. SPSS version 21 software was used for the analyses. A p‐value <.05 was considered significant. Results BDNF levels were significantly lower in maternal and umbilical cord blood in the opium‐addicted group (917.2 31 ± 316.5 and 784.6 ± 242.9 pg/ml, respectively) compared to the control group (1351 ± 375 and 1063 ± 341 pg/ml, respectively) (p < .0001 and p < .0002, respectively). Similarly, NGF level was significantly lower in maternal and umbilical cord blood in the opium‐addicted group (302.7 ± 35.50 and 226.6 ± 45.43 pg/ml, respectively) compared to the control group (345.7 ± 43.16 and 251.2 ± 37.72 pg/ml, respectively) (p < .0001 and p = .0165, respectively). Adverse pregnancy outcomes such as NICU admissions, congenital anomalies, neonatal deaths, meconium contaminated amniotic fluid, respiratory problems, neonatal resuscitation, and low Apgar score were significantly higher in the opium‐addicted group than in the control group. Conclusion The results of this study revealed that opium consumption during pregnancy reduces BDNF and NGF levels in maternal and umbilical cord blood, which may cause neurodevelopmental disorders in later periods of infants' life.

show abstract

“…Ahmadalipour, Ghodrati‐Jaldbakhan, Samaei and Rashidy‐Pour () demonstrated that morphine treatment in dams during pregnancy reduced BDNF levels in hippocampus tissue female pups (Ahmadalipour et al ). In the present study, it seems that morphine treatment in dams during pregnancy enhanced oxidative stress and cell death after neonatal HI through reducing BDNF levels.…”

Section: Discussionmentioning

confidence: 99%

Morphine consumption during pregnancy exacerbates neonatal hypoxia‐ischemia injury in rats

Bornavard

Fanaei

Mirshekar

et al. 2020

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Objective Hypoxia‐Ischemia (HI) is the most common cause of death and disability in human infants. The use of opiate in pregnant women affects their children. The aim of this study was to evaluate the effect of morphine consumption during pregnancy and lactation on vulnerability to neonatal HI in rats. Materials and methods Female Wistar rats were randomly assigned into two groups: Group 1‐Rats that did not receive any treatment during pregnancy and lactation and Group 2‐Rats that received morphine during pregnancy and lactation. After delivery, male offspring were divided into four groups including: (a) SHAM, (b) SHAM/Morphine (SHAM/MO), (c) HI, (d) HI/Morphine (HI/MO). Seven days after HI induction, neurobehavioral tests were performed, and then, brain tissue was taken from the skull to measure cerebral edema, infarct volume, inflammatory factors, oxidative stress, and brain‐derived neurotrophic factor (BDNF). Results Total antioxidant capacity (TAC) and BDNF levels in the HI/MO group were significantly lower than HI and SHAM groups. TNF‐α, C‐reactive protein and total oxidant capacity levels in the HI/MO group were significantly higher than HI and SHAM groups. Cerebral edema and infarct volume in the HI/MO group were significantly higher than the HI group. Conclusion Based on the results, morphine consumption during pregnancy and lactation enhanced the deleterious effects of HI injury in pups.

show abstract

Deleterious effects of prenatal exposure to morphine on the spatial learning and hippocampal BDNF and long-term potentiation in juvenile rats: Beneficial influences of postnatal treadmill exercise and enriched environment

Cited by 42 publications

References 85 publications

Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring

Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring

Brain‐derived neurotrophic factor and nerve growth factor concentrations in maternal and umbilical cord blood of opium‐addicted mothers

Morphine consumption during pregnancy exacerbates neonatal hypoxia‐ischemia injury in rats

Contact Info

Product

Resources

About