Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner
Anika Shimonty,
Fabrizio Pin,
Matthew Prideaux
et al.
Abstract:Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice lacking
Fndc5
(KO), with and without calcium deficiency. Despite their bone being indistinguishable from WT females, KO female mice were partially protected from osteocytic osteolysis and osteoclastic bone resorption when allowed to lactate or when placed on a low-calcium di… Show more
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