Deletion of Dux ameliorates muscular dystrophy in mdx mice by attenuating oxidative stress via Nrf2
Siyuan Sun,
Wen Zhai,
Ruixue Zhang
et al.
Abstract:DUX4 has been widely reported in facioscapulohumeral muscular dystrophy, but its role in Duchenne muscular dystrophy (DMD) is unclear. Dux is the mouse paralog of DUX4. In Dux−/− mdx mice, forelimb grip strength test and treadmill test were performed, and extensor digitorum longus (EDL) contraction properties were measured to assess skeletal muscle function. Pathological changes in mice were determined by serum CK and LDH levels and muscle Masson staining. Inflammatory factors, oxidative stress, and mitochondr… Show more
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