“…As seen from a number of gene deletion studies, parasites which lack certain functional MC proteins show either reduced or no PfEMP1 presentation on the RBC surface (Table 2). [69,81,84,120,[123][124][125] Interactions between the J-dots and the MC are still not well understood, however, a study conducted by Jonsdottir and coworkers suggests the possibility of a transient MC/J-dot trafficking complex (JAM complex) comprised of several proteins (HSP70-x, PF3D7_0801000, PF3D7_0301700, PF3D7_0532300, and PF3D7_0702500) that may be involved in the protein trafficking process. [103] Interestingly, PfPTP7 (PF3D7_0301700), one of the proteins in the JAM complex, is also associated with electron dense vesicles (EDV) that contain PfEMP1.…”