2022
DOI: 10.1371/journal.ppat.1009882
|View full text |Cite
|
Sign up to set email alerts
|

Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer’s clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1

Abstract: Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the surface of infected red blood cells, underpins the parasite’s pathogenicity. Here we describe a protein PF3D7_0301700 (PTP7), that functions at the nexus between the intermediate trafficking organelle, the Maurer’s cleft, and the infected red blood cell surface. Genetic disruption of PTP7 leads to accumulation of vesicles at the Maurer’s clefts, grossly aberrant knob morphology, and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
14
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
3
2

Relationship

0
5

Authors

Journals

citations
Cited by 14 publications
(14 citation statements)
references
References 76 publications
0
14
0
Order By: Relevance
“…[217] antigenic variation, parasite virulence, merozoite egress, and invasion have been identified as well. [69,[73][74][75][76][77][78][79][80][81] The presence of the MC allows the parasite to transport many different and unique proteins into the RBC cytoplasm and beyond.…”
Section: The Structure and Morphology Of The Maurer's Clefts Througho...mentioning
confidence: 99%
See 4 more Smart Citations
“…[217] antigenic variation, parasite virulence, merozoite egress, and invasion have been identified as well. [69,[73][74][75][76][77][78][79][80][81] The presence of the MC allows the parasite to transport many different and unique proteins into the RBC cytoplasm and beyond.…”
Section: The Structure and Morphology Of The Maurer's Clefts Througho...mentioning
confidence: 99%
“…Among the many parasite proteins that can be found at the MC, P. falciparum skeleton-binding protein 1 (PfSBP1), ring exported protein 1 (REX1), membrane associated histidine rich protein 1 (MAHRP1), PfPTP1 (PfEMP1 trafficking protein 1), PfPTP5 (PfEMP1 trafficking protein 5), PfPTP6 (PfEMP1 trafficking protein 6), and PfPTP7 (PfEMP1 trafficking protein 7) represent some of the most well-known ones. [26,[81][82][83][84][85] PfSBP1 is one of the key players that connects the cisterna of the MC to the actin cytoskeleton of the RBC and might play a potential role in luminal phosphorylation. [74] PfPTP1 is involved in the actin-binding process as well, while both PfSBP1 and PfPTP1 are further crucial for the trafficking of PfEMP1.…”
Section: The Structure and Morphology Of The Maurer's Clefts Througho...mentioning
confidence: 99%
See 3 more Smart Citations