Delimitation of the critical stage of hormone-influenced sex differentiation in Hemihaplochromis multicolor (Hilgendorf) (Cichlidae)

Hackmann, Eva; Reinboth, Rudolf

doi:10.1016/0016-6480(74)90086-0

Cited by 62 publications

(27 citation statements)

References 14 publications

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“…This phenomenon has been observed when fishes have been treated with aromatizable androgens at high doses or for extended periods (Hackmann & Reinboth, 1974;Hunter & Donaldson, 1983;Piferrer & Donaldson, 1991;Piferrer et al, 1993). This implies that excess substrates for aromatization can trigger a negative feedback system and re-balance the androgen to oestrogen ratio in the undifferentiated gonadal tissues and other tissues where the signals for male or female differentiation are generated.…”

Section: Discussionmentioning

confidence: 98%

Treatment with an aromatase inhibitor suppresses high‐temperature feminization of genetic male (YY) Nile tilapia

Kwon

McAndrew

Penman

2002

Journal of Fish Biology

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High temperature (36° C) treatment during sexual differentiation caused significant changes in sex ratio in YY male Nile tilapia Oreochromis niloticus fry (64.5% males compared to 100.0% males at 28° C), while dietary treatment with a chemical aromatase inhibitor (AI: FadrozoleTM CGS16949A) during this period suppressed the high temperature feminization (98.9% males). This implies that cytochrome P450 aromatase is mechanistically associated with temperature-dependent sex determination (TSD) in this species. XY male fry did not show significant sex reversal at 36° C. In XX female fry, high temperature treatment resulted in significant masculinization (62.5% males compared with 21.9% males at 28° C), while treatment with AI at either temperature resulted in very high proportions of males (100.0% males at 36° C; 99.0% males at 28° C). These results confirm the importance of aromatase in sexual differentiation in the Nile tilapia below the TSD threshold and suggest that it also plays a role in TSD, at least in the YY genotype

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Section: Discussionmentioning

confidence: 98%

Treatment with an aromatase inhibitor suppresses high‐temperature feminization of genetic male (YY) Nile tilapia

Kwon

McAndrew

Penman

2002

Journal of Fish Biology

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“…This bipotency of germ cells has also been suggested by in vitro experiments in the same species [74], and in vivo in the medaka [75]. Apart from the numerous treatments that are known classically to be effective in inducing feminization (using oestrogens) or masculinization (using androgens), there exist a number of paradoxical results on the feminizing effects of androgens in fish [76][77][78][79][80]. In a genotypic all-female population of Chinook salmon Oncorhynchus tshawytscha, balneation treatments were performed with either the synthetic, aromatizable methyltestosterone (MT) or the synthetic, nonaromatizable androgens methyldehydrotestosterone (MDHT), and the relative masculinizing potencies were MDHT \ MT.…”

Section: Involvement Of Steroid Hormones In Gonochoristic Speciesmentioning

confidence: 97%

Endocrine and environmental aspects of sex differentiation in fish

Baroiller¹,

Guiguen²,

Fostier³

1999

CMLS, Cell. Mol. Life Sci.

407

274

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This paper reviews the current knowledge differentiation, new data, including molecular apconcerning the endocrine and environmental regula-proaches, have confirmed that they are key physiologitions of both gonadal sex differentiation in gonocho-cal steps in the regulation of this process. Environmental factors can strongly influence sex differentiaristic and sex inversion in hermaphroditic fish. Within the central nervous system, gonadotropins seem to tion and sex inversion in gonochoristic and hermaphroditic fish, respectively. The most important play a role in triggering sex inversion in hermaphroditic fish. In gonochorists, although potentially ac-environmental determinant of sex would appear to be temperature in the former species, and social factors tive around this period, the hypothalamo-pituitary axis is probably not involved in triggering sex differ-in the latter. Interactions between environmental factors and genotype have been suggested for both gonoentiation. Although steroids and steroidogenic enzymes are probably not the initial triggers of sex choristic and hermaphroditic fish.

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“…Traditionally, androgen administration has been used to obtain all-male populations, whereas oestrogen administration resulted in all-female populations (Hunter & Donaldson, 1983). However, a paradoxical increase in the number of females after androgen treatment has also been reported in different fish species such as Hemihaplochromis multicolor (Hilgendorf) (Hackman & Reinboth, 1974), tilapia Oreochromis mossambicus (Peters) (Nakamura, 1975), channel catfish Ictalurus punctatus (Rafinesque) (Goudie et al, 1983), rainbow trout, Oncorhynchus mykiss (Walbaum) (Solar et al, 1984), coho salmon O. kisutch (Walbaum) (Piferrer & Donaldson, 1991) and chinook salmon O. tshawytscha (Walbaum) . This effect was attributed earlier to an inhibition of the synthesis of the endogenous androgen (Hackman & Reinboth, 1974).…”

Section: Introductionmentioning

confidence: 93%

Critical period of androgen‐inducible sex differentiation in a teleost fish, the European sea bass

Blázquez

Felip

Zanuy

et al. 2001

Journal of Fish Biology

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Twenty-day exposures to 17 -methyltestosterone (MT) (10 mg kg 1 food) starting at 86 or 106 days post fertilization (DPF) resulted in a complete masculinization of sea bass Dicentrarchus labrax, as opposed to 46% females present in the controls. Earlier exposures failed to suppress ovarian development, resulting in a variable number of females (range 10·5-49·5%). All treatments assayed between 110 and 210 DPF induced a complete masculinization, regardless of the androgen or the dose tested. However, a dose dependent increase in the number of fish with intratesticular oocytes was observed after MT but not after 17 -methyldihydrotestosterone (MDHT) administration. This might be a reflection of the capability of MT and not of MDHT to be converted into oestradiol by the action of aromatase. One hundred-day exposures to either of the androgens (10 mg kg 1 food) starting at 60 or 160 DPF resulted in a total suppression of ovarian development and a partial induction of sterility. Complete sterility was accomplished after 200 days of exposure starting at early ontogenesis (60-260 DPF). These deleterious effects on gonadal development were later confirmed by a dramatic reduction of the gonadosomatic index. In addition, around the first year of age, growth was significantly depressed in all groups except those for which treatments started at the latest (160-260 DPF; experiment 1) or the earliest and shortest (46-66 DPF; experiment 2). Hence, the critical period of androgen-inducible masculinization is located between 96 and 126 DPF and coincides with a rapid proliferation of primordial germ cells in the sexually undifferentiated gonad. 2001 The Fisheries Society of the British Isles

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Delimitation of the critical stage of hormone-influenced sex differentiation in Hemihaplochromis multicolor (Hilgendorf) (Cichlidae)

Cited by 62 publications

References 14 publications

Treatment with an aromatase inhibitor suppresses high‐temperature feminization of genetic male (YY) Nile tilapia

Treatment with an aromatase inhibitor suppresses high‐temperature feminization of genetic male (YY) Nile tilapia

Endocrine and environmental aspects of sex differentiation in fish

Critical period of androgen‐inducible sex differentiation in a teleost fish, the European sea bass

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