2024
DOI: 10.1101/2024.02.13.580145
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Delineating the shape of COPII coated membrane bud

Sanjoy Paul,
Anjon Audhya,
Qiang Cui

Abstract: Curvature-generating proteins that direct membrane trafficking assemble on the surface of lipid bilayers to bud transport intermediates, which move protein and lipid cargoes from one cellular compartment to another. Our recent study on the COPII protein Sar1 showed that the inserted volume of the protein into the membrane determines the degree of membrane bending. However, it is unclear what controls the overall shape of the membrane bud once curvature induction has begun. In vitro experiments showed that exce… Show more

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