Delirium in hospitalized COVID-19 patients: a prospective, multicenter, cohort study

Zhu, Weiming; Bai, Yangjing; Li, Simin; Zhang, Meng; Chen, Jian; Xie, Peng; Bai, Xin; Zhou, Dong; Jiang, Yan

doi:10.1007/s00415-023-11882-0

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…We found that transaminases at hospital admission were higher in the patients who developed delirium compared to the patients who did not. A recent prospective, multicenter, cohort study by Zhu et al [60], who enrolled 4589 patients hospitalized with SARS-CoV-2 infection, detected an association between aspartic transaminase/alanine transaminase ratio and delirium. SARS-CoV-2 infection can damage the liver through various mechanisms [61,62].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Association between Delirium and Malnutrition in COVID-19 Survivors: A Geriatric Perspective

Damanti,

Cilla,

Vitali

et al. 2023

Nutrients

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Older individuals face an elevated risk of developing geriatric syndromes when confronted with acute stressors like COVID-19. We assessed the connection between in-hospital delirium, malnutrition, and frailty in a cohort of COVID-19 survivors. Patients aged ≥65, hospitalized in a tertiary hospital in Milan for SARS-CoV-2 pneumonia, were enrolled and screened for in-hospital delirium with the 4 ‘A’s Test (4AT) performed twice daily (morning and evening) during hospital stay. Malnutrition was assessed with the malnutrition universal screening tool (MUST) at hospital admission and with the mini-nutritional assessment short-form (MNA-SF) one month after hospital discharge. Frailty was computed with the frailty index one month after hospital discharge. Fifty patients (median age 78.5, 56% male) were enrolled. At hospital admission, 10% were malnourished. The 13 patients (26%) who developed delirium were frailer (7 vs. 4), experienced a higher in-hospital mortality (5 vs. 3), and were more malnourished one month after discharge (3 of the 4 patients with delirium vs. 6 of the 28 patients without delirium who presented at follow up). The 4AT scores correlated with the MNA-SF scores (r = −0.55, p = 0.006) and frailty (r = 0.35, p = 0.001). Frailty also correlated with MUST (r = 0.3, p = 0.04), MNA-SF (r = −0.42, p = 0.02), and hospitalization length (r = 0.44, p = 0.001). Delirium, malnutrition, and frailty are correlated in COVID-19 survivors. Screening for these geriatric syndromes should be incorporated in routine clinical practice.

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Section: Discussionmentioning

confidence: 99%

Exploring the Association between Delirium and Malnutrition in COVID-19 Survivors: A Geriatric Perspective

Damanti,

Cilla,

Vitali

et al. 2023

Nutrients

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Association of peripheral B cells and delirium: combined single-cell sequencing and Mendelian randomization analysis

Tan,

Pan,

Wei

et al. 2024

Front. Neurol.

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BackgroundDelirium seriously affects the prognosis of patients and greatly reduces the ability to work and live. Peripheral inflammatory events may contribute to the development of delirium, the mechanism of which is still unclear. There is a lack of effective diagnostic and treatments for delirium in clinical practice. The study aims to investigate alterations in peripheral immune cell subsets under inflammatory stress and to explore causal associations with delirium.MethodsSingle-cell transcriptional sequencing data of human peripheral blood mononuclear cells (PBMC) before and after lipopolysaccharide (LPS) intervention were processed by the Seurat package in R software. PBMC subsets and cellular markers were defined after downscaling and clustering by the Harmony algorithm to identify characteristic subsets in the context of inflammatory stress. Subsequently, a two-sample Mendelian randomization (MR) study was used to explore the causal associations of these inflammation-related PBMC subsets and their molecular phenotypes with delirium. Based on publicly available genetic data, the study incorporated 70 PBMC-associated immune traits, including 8 types of circulating immune cells, 33 B cell subsets and molecular phenotypes, 13 T cell subsets, and 16 B cell-associated cytokines. The results were also validated for robustness, heterogeneity, and horizontal pleiotropy.ResultsUnder LPS-induced inflammatory stress, B cells, T cells, monocytes, and dendritic cells in human PBMC showed significant activation and quantitative changes. Of these, only lymphocyte and B cell counts were causally associated with delirium risk. This risk link is also seen in the TNF pathway. Further studies of B cells and their subsets revealed that this association may be related to unswitched memory B cells and CD27 expressed on memory B cells. Annotation of the screened SNPs revealed significant polymorphisms in CD27 and CD40 annotated by rs25680 and rs9883798, respectively. The functions of the key annotated genes may be related to the regulation of immune responses, cell differentiation, proliferation, and intercellular interactions.ConclusionThe present study revealed the potential possibility that B cell, memory B cell subset, and TNF-related molecules may be involved in the development of delirium due to peripheral inflammation, which can provide clues for further investigation of delirium prevention and treatment strategies.

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Delirium in hospitalized COVID-19 patients: a prospective, multicenter, cohort study

Cited by 2 publications

References 39 publications

Exploring the Association between Delirium and Malnutrition in COVID-19 Survivors: A Geriatric Perspective

Exploring the Association between Delirium and Malnutrition in COVID-19 Survivors: A Geriatric Perspective

Association of peripheral B cells and delirium: combined single-cell sequencing and Mendelian randomization analysis

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