2020
DOI: 10.1007/s42399-020-00474-y
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Delirium in Older People with COVID-19: Clinical Scenario and Literature Review

Demelza Emmerton,
Ahmed Abdelhafiz

Abstract: Delirium is a potentially fatal acute brain dysfunction that is characterised by inattention and fluctuating mental changes. It is indicative of an acute serious organ failure or acute infection. Delirium is also associated with undesirable health outcomes that include prolonged hospital stay, long-term cognitive decline and increased mortality. The new SARS-CoV-2 shows, not only pulmonary tropism but also, neurotropism which results in delirium in the acute phase illness particularly in the older age groups. … Show more

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Cited by 26 publications
(29 citation statements)
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“…A meta-analysis reported that older patients hospitalized in acute care with delirium had up to 2 times increased risk of dying in the 2-year follow-up after hospital discharge, whereas in our study, patients with COVID-19 and delirium had a doubled risk of dying only during the acute phase ( 10 ). Recent emerging studies also showed the association of delirium in the course of COVID-19 with increased mortality and worse physical function after hospital discharge ( 25 , 26 ).…”
Section: Discussionmentioning
confidence: 99%
“…A meta-analysis reported that older patients hospitalized in acute care with delirium had up to 2 times increased risk of dying in the 2-year follow-up after hospital discharge, whereas in our study, patients with COVID-19 and delirium had a doubled risk of dying only during the acute phase ( 10 ). Recent emerging studies also showed the association of delirium in the course of COVID-19 with increased mortality and worse physical function after hospital discharge ( 25 , 26 ).…”
Section: Discussionmentioning
confidence: 99%
“…As a result, respite care with a family support may be required. Mutual trust between patients and staff, patients’ involvement in their own decision-making, well-coordinated collaboration between health care and social services that includes symptom control and continuity of care are the fundamentals of successful transitional care [ 20 ]. This approach will effectively address the holistic needs of the vulnerable older people with dementia and COVID-19 and cares for this population as they transition back from the hospital to the community.…”
Section: Managementmentioning
confidence: 99%
“…To date, delirium prevalence in COVID-19 varies greatly between studies, with some, published in the early months of the pandemic, reporting high or very high rates, 3,[8][9][10][11] and other more recent ones finding lower prevalence. [12][13][14] Furthermore, there are only a few studies that have investigated the risk factors of delirium in patients with COVID-19 15,16 and there are contrasting findings regarding the potential association of delirium with mortality in this context. 3,8,9,[13][14][15] There is therefore a need for further exploration of these issues.…”
Section: Introductionmentioning
confidence: 99%