Delirium in patients with acute ischemic stroke admitted to the non-intensive stroke unit: Incidence and association between clinical features and inflammatory markers

Abstract

Eleven (18.3%) of 60 patients were diagnosed with delirium, and the majority (n=8, 72.7%) was the hypoactive type. Delirious and non-delirious patients had similar demographic and clinical features. Delirious patients had significantly higher lengths of hospital stay, National Institutes of Health Stroke Scale (NIHSS) at admission and discharge compared to non-delirious patients. In addition, there was no significant statistical difference between delirious and non-delirious patients with AIS in respect of levels of TNF-alpha, IL-1 beta, IL-18, BDNF and NSE. This study suggests that delirium is not scarce in patients with AIS admitted to the non-intensive stroke unit, and that delirium developing after AIS seems not to be associated with serum TNF-alpha, IL-1 beta, IL-18, BDNF and NSE but is associated with length of hospital stay and stroke severity.

The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study

“…All reasons for exclusion are detailed in Figure 1. We included 18 studies [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47], adding to 15 studies from the original review.…”

Delirium Assessment in Acute Stroke: A Systematic Review and Meta-Analysis of Incidence, Assessment Tools, and Assessment Frequencies

“…A total of 134 articles were read in full length and 30 were included in the review. 15-44 In these 30 articles, 24 unique populations were identified (Figure 1). The discrepancy between the number of articles and the number of unique populations was caused by the fact that the same population was described in more than one article.…”

Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium

“…Other studies, however, did not find similar associations [15-17]. Increased neuron-specific enolase, an enzyme expressed in neurons in the central nervous system [18], has been reported in delirium patients in three studies [19-21], whereas one study in stroke patients could not replicate these findings [22]. Dissimilar study populations as well as lack of tissue specificity for both S100B and neuron-specific enolase may partly explain the divergent reports.…”