Delitpyrones: α-Pyrone Derivatives from a Freshwater Delitschia sp.

Rivera‐Chávez, José; El‐Elimat, Tamam; Gallagher, Jacklyn M.; Graf, Tyler N.; Fournier, Jacques; Panigrahi, Gatikrushna; Deep, Gagan; Bunch, Rick; Raja, Huzefa A.; Oberlies, Nicholas H.

doi:10.1055/a-0654-5850

Cited by 18 publications

(18 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Barr, Mycotaxon 76: 109 (2000) The family Delitschiaceae, typified by Delitschia, occurs on bovine dung (Doveri 2011), or rarely on aged wood or plants (Hyde et al 2013). Recent studies by Rivera-Chávez et al (2018) reported Delitschia species from submerged wood in freshwater habitat and Delitschia bispora from a water-cooling tower (Eaton & Jones 1970). Wijayawardene et al (2018) reported three genera in this family (Delitschia, Ohleriella and Semidelitschia), but sequence data is available only for Delitschia.…”

Section: Caryospora Quercusmentioning

confidence: 99%

“…Wijayawardene et al (2018) reported three genera in this family (Delitschia, Ohleriella and Semidelitschia), but sequence data is available only for Delitschia. Recently identified Delitschia strains from submerged wood show a diversity of important chemicals (Rivera-Chávez et al 2018) that show activity towards prostate cancer cell lines. Study of the bioactive from sample accessioned as G858 (Delitschia sp.)…”

Section: Caryospora Quercusmentioning

confidence: 99%

See 1 more Smart Citation

Diversity, morphology and molecular phylogeny of Dothideomycetes on decaying wild seed pods and fruits

Jayasiri¹,

Hyde²,

Jones³

et al. 2019

Mycosphere

137

178

View full text Add to dashboard Cite

Dothideomycetes is one of the largest and most diverse class of ascomycetes. Its members are reported from many plant parts, but less has been reported from wild seed pods and fruits. Dothideomycetes can be seed-borne or colonize fruits and seed pods when they fall to the ground. We studied the Dothideomycetes found on wild fruits and seed pods, mainly in Thailand (tropical), and to a lesser extent, in China (temperate) and UK (temperate). We describe eight new genera, 50 new species, provide 38 new host records and propose seven new combinations. The new genera are

show abstract

Section: Caryospora Quercusmentioning

confidence: 99%

Section: Caryospora Quercusmentioning

confidence: 99%

Diversity, morphology and molecular phylogeny of Dothideomycetes on decaying wild seed pods and fruits

Jayasiri¹,

Hyde²,

Jones³

et al. 2019

Mycosphere

137

178

View full text Add to dashboard Cite

show abstract

“…In addition, natural products with α-pyrone sub-structure have antibacterial ( Zhang et al, 2013 ), anti-influenza A virus ( Hou et al, 2018 ), and anti-HIV ( Appendino et al, 2007 ) activities. Some of them are signal molecules ( Brachmann et al, 2013 ), while some are also cytotoxic agents against tumor cells ( Rivera-Chávez et al, 2019 ; Zhu et al, 2019 ). In particular, dibenzo-α-pyrone ( 3 ) belongs to a significant group of heptaketide coumarin metabolites that have a fused tricyclic core ( Figure 1A ), commonly identified from fungi, bacteria, and plants ( Lai et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors

Liu

Wang

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

Inducible nitric oxide synthase (iNOS) produces NO from l-arginine and plays critical roles in inflammation and immune activation. Selective and potent iNOS inhibitors may be potentially used in many indications, such as rheumatoid arthritis, pain, and neurodegeration. In the current study, five new compounds, including a dibenzo-α- pyrone derivative ellagic acid B (5) and four α-pyrones diaporpyrone A–D (9–12), together with three known compounds (6–8), were isolated from the endophytic fungus Diaporthe sp. CB10100. The structures of these new natural products were unambiguously elucidated using NMR, HRESIMS or electronic circular dichroism calculations. Ellagic acid B (5) features a tetracyclic 6/6/6/6 ring system with a fused 2H-chromene, which is different from ellagic acid (4) with a fused 2H-chromen-2-one. Both 2-hydroxy-alternariol (6) and alternariol (7) reduced the expression of iNOS at protein levels in a dose-dependent manner, using a lipopolysaccharide (LPS)-induced RAW264.7 cell models. Also, they decreased the protein expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin-6 and monocyte chemotactic protein 1. Importantly, 6 and 7 significantly reduced the production of NO as low as 10 μM in LPS-induced RAW264.7 cells. Molecular docking of 6 and 7 to iNOS further suggests that both of them may interact with iNOS. Our study suggests that 6 and 7, as well as the alternariol scaffold may be further developed as potential iNOS inhibitors.

show abstract

“…The family Delitschiaceae is a basal family (along with Massariaceae) in the order Pleosporales (Zhang et al 2012;Hyde et al 2013), comprising mainly terrestrial and saprobic species occurring on herbivore dung (e.g., Kruys et al 2006;Doveri 2011), aged wood, and plants (Hyde et al 2013) or submerged wood (Hyde and Steinke 1996;Rivera-Chávez et al 2019); one species was identified from decaying fruits of Nypa fruticans (Jayasiri et al 2019). The family is monogeneric, including only the genus Delitschia, with relatively few species (Jayasiri et al 2019).…”

Section: Section Editor: Gerhard Ramboldmentioning

confidence: 99%

Two pleosporalean root-colonizing fungi, Fuscosphaeria hungarica gen. et sp. nov. and Delitschia chaetomioides, from a semiarid grassland in Hungary

Pintye

Knapp

2021

Mycol Progress

View full text Add to dashboard Cite

In this study, we investigated two unidentified lineages of root-colonizing fungi belonging to the order Pleosporales (Dothideomycetes), which were isolated from Festuca vaginata (Poaceae), a dominant grass species in the semiarid sandy grasslands of Hungary. For molecular phylogenetic studies, seven loci (internal transcribed spacer, partial large subunit and small subunit region of nrRNA, partial transcription elongation factor 1-α, RNA polymerase II largest subunit, RNA polymerase II second largest subunit, and ß-tubulin genes) were amplified and sequenced. Based on morphology and multilocus phylogenetic analyses, we found that one lineage belonged to Delitschia chaetomioides P. Karst. (Delitschiaceae), and the isolates of the other lineage represented a novel monotypic genus in the family Trematosphaeriaceae (suborder Massarineae). For this lineage, we proposed a new genus, Fuscosphaeria, represented by a single species, F. hungarica. In both lineages, only immature and degenerated sporocarps could be induced. These were sterile, black, globose, or depressed globose structures with numerous mycelioid appendages submerged in culture media or on the surface of autoclaved plant materials. Both species are first reported here as root-colonizing fungi.

show abstract

Delitpyrones: α-Pyrone Derivatives from a Freshwater Delitschia sp.

Cited by 18 publications

References 40 publications

Diversity, morphology and molecular phylogeny of Dothideomycetes on decaying wild seed pods and fruits

Diversity, morphology and molecular phylogeny of Dothideomycetes on decaying wild seed pods and fruits

Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors

Two pleosporalean root-colonizing fungi, Fuscosphaeria hungarica gen. et sp. nov. and Delitschia chaetomioides, from a semiarid grassland in Hungary

Contact Info

Product

Resources

About