Delivering macrolide antibiotics to heal a broken heart – And other inflammatory conditions

Venditto, Vincent J.; Feola, David J.

doi:10.1016/j.addr.2022.114252

Cited by 6 publications

(3 citation statements)

References 228 publications

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Section: Discussionmentioning

confidence: 99%

“…[23] Because of their ability to effectively combat various pathogens, macrolides are widely used in the clinical treatment of respiratory tract, gastrointestinal, and maternal infections. [24] A recent multicenter prospective clinical study demonstrated that a single oral dose of azithromycin can reduce the risk of maternal sepsis or death in women planning a vaginal birth. [25]…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and safety of clarithromycin for patients with sepsis or septic shock: a systematic review and meta-analysis

Zhao,

Yao,

Yang

et al. 2023

Emerg Crit Care Med

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Background Clarithromycin exerts an immunomodulatory role in several human diseases. However, whether this effect improves the prognosis in patients with sepsis remains controversial, and higher levels of clinical evidence are urgently needed. To the best of our knowledge, no meta-analysis to date has reported the clinical efficacy and safety of clarithromycin in sepsis. Methods A comprehensive literature search of PubMed, EMBASE, and the Cochrane Library was conducted up to December 31, 2022. Only randomized controlled trials comparing the clinical efficacy and safety of clarithromycin with controls among patients with sepsis or septic shock were included. Data were pooled by applying a fixed-effects model and a relative risk (RR) estimate with 95% confidence intervals (CIs) using Review Manager (version 5.3; Cochrane Collaboration, Copenhagen, Denmark). Results Three randomized controlled trials involving a total of 910 patients were included. The pooled results confirmed that clarithromycin had no beneficial effect on progression to multiple organ dysfunction syndrome (RR: 1.51; 95% CI: 1.02–2.25; P = 0.04; I 2 = 0%), 28-day mortality (RR: 1.09; 95% CI: 0.87–1.36; P = 0.46; I 2 = 0%), and 90-day mortality (RR: 0.86; 95% CI: 0.71–1.03; P = 0.10; I 2 = 81%) in patients with sepsis or septic shock. Moreover, there was no difference in other serious adverse events between patients who received clarithromycin and those in the control group (RR: 1.02; 95% CI: 0.87–1.19; P = 0.83; I 2 = 18%). Conclusion Our meta-analysis did not reveal an improvement to short-term outcomes in patients with sepsis treated with clarithromycin. However, administration of clarithromycin did not increase the risk of adverse events.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of clarithromycin for patients with sepsis or septic shock: a systematic review and meta-analysis

Zhao,

Yao,

Yang

et al. 2023

Emerg Crit Care Med

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“…In detail, they selectively block the translation of a subset of cellular proteins by antibiotic structure, being recently defined as “modulators of translation”, being a promising drugs against antibiotic resistance [ 4 ]. Alongside the synthesis of new macrolide derivatives to improve the bioavailability and antibacterial properties, new delivery systems have been investigated for their administration [ 5 ]. Interestingly the delivery of antibiotics using nanocarriers is a promising strategy to overcome drug resistance [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery

Tannous

Appleton

Hoti

et al. 2022

Gels

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Macrolides are widely used antibiotics with a broad spectrum of activity. The development of drug carriers to deliver this type of antibiotics has attracted much research. The present study aims at developing new swellable dextrin-based nanohydrogels for the topical delivery of rokitamycin, as model macrolide. Rokitamycin is a synthetic analogous of macrolides with advantageous characteristics as far as bacterial uptake and post-antibiotic effect are concerned. It is also indicated for the treatment of severe infections caused by Acanthamoeba and for topical infections. The nanohydrogels have been prepared from two types of cross-linked polymers obtained by using β-cyclodextrin or Linecaps® was provided by the Roquette Italia SPA (Cassano Spinola, Al, Italy) as building blocks. The cross-linked polymers have been then formulated into aqueous nanosuspensions refined and tuned to achieve the incorporation of the drug. Cross-linked β-cyclodextrin (β-CD) and Linecaps® (LC) polymers formed dextrin-based nanohydrogels with high swelling degree and mucoadhesion capability. Rokitamycin was loaded into the nanohydrogels displaying an average size around 200 nm with negative surface charge. In vitro kinetic profiles of free and loaded drug in nanohydrogels were compared at two pH levels. Interestingly, a sustained and controlled release was obtained at skin pH level due to the high degree of swelling and a pH responsiveness possibly. The results collected suggest that these nanohydrogels are promising for the delivery of rokitamycin and may pave the way for the topical delivery of other macrolide antibiotics.

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Determination of Macrolides in Water Using Solid‐Phase Extraction and Supercritical Fluid Chromatography‐Tandem Mass Spectrometry

Ovchinnikov,

Vakhrameev,

Voronov

et al. 2024

J of Separation Science

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Macrolides are a group of compounds used to treat bacterial infections in humans and animals. Their widespread use results in the contamination of the water environment, which, on the one hand, has a detrimental effect on aquatic organisms and, on the other hand, can lead to the emergence of resistant strains of microorganisms. All of the above determines the need for monitoring of these compounds in the environment, particularly, in water objects. Usually, the high‐performance liquid chromatography combined with tandem mass spectrometry method is used to solve this problem, however, this work shows the possibility of using the supercritical fluid chromatography‐tandem mass spectrometry method. An approach for the determination of four common macrolides, namely erythromycin, clarithromycin, midecamycin, and josamycin, was developed. The use of solid‐phase extraction allowed to achieve limits of quantification at 0.57–6.8 ng/L. The presented approach was validated and tested on a real object—a sample of municipal wastewater.

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Delivering macrolide antibiotics to heal a broken heart – And other inflammatory conditions

Cited by 6 publications

References 228 publications

Efficacy and safety of clarithromycin for patients with sepsis or septic shock: a systematic review and meta-analysis

Efficacy and safety of clarithromycin for patients with sepsis or septic shock: a systematic review and meta-analysis

Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery

Determination of Macrolides in Water Using Solid‐Phase Extraction and Supercritical Fluid Chromatography‐Tandem Mass Spectrometry

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