Delivery in asymptomatic Italian woman with SARS-CoV-2 infection.

Socio, Giuseppe Vittorio De; Malincarne, Lisa; Arena, Saverio; Troiani, Stefania; Benedetti, Sara; Camilloni, Barbara; Epicoco, Giorgio; Mencacci, Antonella; Francisci, Daniela

doi:10.4084/mjhid.2020.033

Cited by 19 publications

(26 citation statements)

References 5 publications

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“…Twenty-eight case reports, [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][32][33][34][36][37][38][39][40]42,43,45 and nine retrospective case series. [27][28][29][30][31]35,41,44,46 These report articles were included for narrative analysis.…”

Section: Study Designsmentioning

confidence: 99%

“…The included studies were reports from Australia (n = 1), 32 Belgium (n = 1), 33 Canada (n = 1), 34 China (n = 21), 12,13,[18][19][20][22][23][24][25][26][27][28][29][30][31][41][42][43][44][45][46] Germany (n = 2), 14,35 Italy (n = 6), 10,11,21,[36][37][38] Jordan (n = 1), 39 Singapore (n = 1), 17 Turkey (n = 2), 16,40 and the Republic of Korea (n = 1). 15 No additional information was available on the setting characteristics of the cases described.…”

Section: Settingsmentioning

confidence: 99%

“…Most of the cases were tested during the acute phase, 1-5 days after maternal symptoms 14,18,22,26,29,31,34,36,[38][39][40][41]45 or between 5 and 8 days after onset of maternal symptoms. 10,13,16,20,32,33,37 Other samples were collected during the convalescent phase at 14-19 days after maternal 17,24,29,42 or infant onset of symptoms. 25 The time between maternal symptoms and breast milk sample collection was not reported in four neonates with COVID-19 21,35 and other 25 neonates without infection.…”

Section: Participantsmentioning

confidence: 99%

See 2 more Smart Citations

Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

Centeno‐Tablante

Medina‐Rivera

Finkelstein

et al. 2020

Annals of the New York Academy of Sciences

148

123

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The pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with a novel coronavirus strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, there is limited information on potential transmission of the infection from mother to child, particularly through breast milk and breastfeeding. Here, we provide a living systematic review to capture information that might necessitate changes in the guidance on breast milk and breastfeeding given the uncertainty in this area. Our search retrieved 19,414 total records; 605 were considered for full-text eligibility and no ongoing trials were identified. Our review includes 340 records, 37 with breast milk samples and 303 without. The 37 articles with analyzed breast milk samples reported on 77 mothers who were breastfeeding their children; among them, 19 of 77 children were confirmed COVID-19 cases based on RT-PCR assays, including 14 neonates and five older infants. Nine of the 68 analyzed breast milk samples from mothers with COVID-19 were positive for SARS-CoV-2 RNA; of the exposed infants, four were positive and two were negative for COVID-19. Currently, there is no evidence of SARS-CoV-2 transmission through breast milk. Studies are needed with longer follow-up periods that collect data on infant feeding practices and on viral presence in breast milk.

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Section: Study Designsmentioning

confidence: 99%

Section: Settingsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

See 1 more Smart Citation

Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

Centeno‐Tablante

Medina‐Rivera

Finkelstein

et al. 2020

Annals of the New York Academy of Sciences

148

123

View full text Add to dashboard Cite

show abstract

“…On the other hand, this review has revealed evidence for antibodies (IgG/IgM) against SARS-CoV-2 among infants tested negative for COVID-19 but born to COVID-19 mothers. Antibodies were quanti ed in 11 infants [13][14][15][16][17][18] , where 10 out of 11 infants (90.9%) had IgG/IgM against SARS-CoV-2. One infants whose antibodies were not detected tested positive for COVID-19 13 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the detection of immunoglobulin (IgM/IgG) against SARS-CoV-2 IgG and IgM among infants born COVID-19 con rmed mothers but themselves tested COVID-19 negative have been reported [13][14][15][16][17][18] . This serological evidence raises more concern about the possible mother to child transmission of antibodies against SARS-CoV-2 8,9 .…”

Section: Introductionmentioning

confidence: 99%

A systematic review of vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19

Bwire¹,

Njiro²,

Mwakawanga³

et al. 2020

Preprint

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Amidst the Coronavirus Disease 2019 (COVID-19) pandemic, evidence on vertical transmission and natural passive immunity among the newborns exposed to COVID-19 is scanty and varies. This pose a challenge on preventive interventions for the newborns. We conducted a systematic review to first, determine the likelihood of vertical transmission among COVID-19 exposed infants and second, determine whether antibodies against Severe Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/ COVID-19 virus exist among COVID-19 vertically exposed but negative infants. This review registered in PROSPERO searched evidence from PubMed/ MEDLINE and Google Scholar, among others. About 517 studies were retrieved, where only 33 articles (5.8%) qualified for final analysis. A total of 205 infants born to SARS-CoV-2 positive mothers were pooled from 33 eligible studies. Overall, 6.3% (13/205; 95%CI: 3.0%-9.7%) of the infants tested positive for COVID-19 virus at birth. Of 33 eligible studies, 6 studies (18.8%) reported about IgG/IgM against SARS-CoV-2. Anti-SARS-CoV-2 IgG/IgM were detected in 90% (10/11; 95%CI: 73.9%-107.9%) of infants who had no COVID-19 but vertically exposed. In conclusion, the current evidence revealed a low possibility of vertical transmission of COVID-19 while antibodies against SARS-CoV-2 were detected in most of the infants who had no COVID-19. Further studies on perinatal outcomes and the magnitude of natural passive immunity in infants born to mothers with COVID-19 are warranted.

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Possible vertical transmission and antibodies against SARS‐CoV‐2 among infants born to mothers with COVID‐19: A living systematic review

Bwire

Njiro

Mwakawanga

et al. 2020

Journal of Medical Virology

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Current evidence suggests that coronavirus disease 2019 (COVID‐19), caused by severe respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is predominantly transmitted from human‐to‐human. However, evidence on vertical transmission and natural passive immunity among the newborns exposed to COVID‐19 is scanty and varies. This poses a challenge on preventive interventions for the newborns. We conducted a systematic review to first, determine the likelihood of vertical transmission among COVID‐19 exposed infants and second, determine whether antibodies against SARS‐CoV‐2 were generated among COVID‐19 vertically exposed but negative infants. This review registered in PROSPERO searched evidence from PubMed/MEDLINE and Google Scholar, among others. About 517 studies were pooled, where 33 articles (5.8%) met the inclusion criteria such as infection prevention and control measures at birth. A total of 205 infants born to COVID‐19 positive mothers were studied. Overall, 6.3% (13/205; 95% CI: 3.0%–9.7%) of the infants tested positive for COVID‐19 virus at birth. Of 33 eligible studies, six studies (18.8%) reported about immunoglobulin G/M (IgG/IgM) against SARS‐CoV‐2. IgG/IgM were detected in 90% infants (10/11; 95% CI: 73.9%–107.9%) who tested negative for COVID‐19 virus. The median antibody levels detected were 75.49 AU/ml (range, 7.25–140.32 AU/ml) and 3.79 AU/ml (range, 0.16–45.83 AU/ml), p = .0041 for IgG and IgM, respectively. In conclusion, the current evidence revealed a low possibility of vertical transmission of COVID‐19 and antibodies against SARS‐CoV‐2 were detected among vertically exposed but negative infants. Further studies on transplacental transmission and the magnitude of natural passive immunity in infants born to mothers with COVID‐19 are warranted.

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Delivery in asymptomatic Italian woman with SARS-CoV-2 infection.

Abstract: Citation: De Socio G.V., Malincarne L., Arena S., Troiani S., Benedetti S., Camilloni B., Epicoco G., Mencacci A., Francisci D. Delivery in asymptomatic italian woman with SARS-CoV-2 infection. Mediterr J Hematol Infect Dis 2020, 12(1): e2020033, DOI: http://dx.

Cited by 19 publications

References 5 publications

Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

A systematic review of vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19

Possible vertical transmission and antibodies against SARS‐CoV‐2 among infants born to mothers with COVID‐19: A living systematic review

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