Delivery of anti-cancer and anti-depression doxepin drug by nickel oxide nanoparticles originated from the Cressa nudicaulis plant extract

Abstract

Cressa nudicaulis is used to prepare NiO NPs. The prepared nanoparticles were approved for doxepin loading. The drug release properties were also investigated at pH 6.5 and 37 °C. An MTT experiment was performed on the human hepatocellular carcinoma cell line Huh-7.

Zinc oxide‐cadmium(II) sulfide heterostructure as a potential photocatalyst for preparing substituted chromenes and its anti‐liver cancer activity

“…By comparing the viability of cancer cells and normal cells after nanoparticle treatment, then, the selectivity of nanoparticles in inducing cytotoxic effects can be assessed. Up to now, various simple or decorated metal oxide nanoparticles as well as many plant extracts have been documented because of their anticancer and cytotoxic properties 27–40 . One mechanism by which metal oxide nanoparticles induce cytotoxic effects is through the generation of reactive oxygen species (ROS) that induce oxidative stress and damage.…”

“…Up to now, various simple or decorated metal oxide nanoparticles as well as many plant extracts have been documented because of their anticancer and cytotoxic properties. [27][28][29][30][31][32][33][34][35][36][37][38][39][40] One mechanism by which metal oxide nanoparticles induce cytotoxic effects is through the generation of reactive oxygen species (ROS) that induce oxidative stress and damage. Because cancer cells are frequently associated with higher levels of ROS, they may be more susceptible to the additional oxidative damage.…”