Delivery of Hydrophobic Anticancer Drugs by Hydrophobically Modified Alginate Based Magnetic Nanocarrier

Abstract

Since most of the anticancer drugs have low solubility in water, the clinical use of them is limited unless by some modification the solubility increases or the drug is carried with a soluble compartment. To solve this problem, we prepared a magnetic nanocarrier with a hydrophobic surface based on oleic acid chains in which hydrophobic drug molecules such as doxorubicin hydrochloride (DOX) and paclitaxel (PTX) are easily adsorbed onto the surface. Since the drug molecules are physically adsorbed on the surface, large amounts of DOX (282 mg·g–1) and PTX (316 mg·g–1) were immobilized onto the nanocarrier. Then, the surface of the drug loaded magnetic core was covered by a smart pH-sensitive shell based on sodium alginate. The alginate shell around the magnetic core increased the stability and biocompatibility of the drug loaded nanocarrier. The results of the drug release profile showed that the drug molecules were released faster in acidic medium than in the neutral medium. The MTT assay of the nanocarrier showed low toxicity toward MCF-7 and HeLa cells, while the drug loaded nanocarrier had high toxicity, even higher than the free drugs. Owing to these advantages, the resulting nanocarrier exhibits a promising potential for delivery of hydrophobic drug molecules in clinical applications.

Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy

“…The thermal degradation curve of OA-MSNs involved the main weight loss in the temperature range of 200–600 ​°C due to the decomposition of aminopropyl groups. Moreover, the weight loss at 200–450 ​°C may result from the degradation of OA molecules [ 49 ]. The thermal curve of OA-MSNs/DTX showed more weight loss at the temperature of 800 ​°C than that of OA-MSNs, which is mainly due to the degradation of DTX.…”

5FU encapsulated polyglycerol sebacate nanoparticles as anti-cancer drug carriers

“…5FU was dissolved in 1 mL of DMSO and this solution was added to 9 mL of distilled water (1 : 10) containing 250 mg of PGS (25 mg mL −1 ). 26 This mixture was left stirring overnight. Then, the solution was centrifuged at a high speed of 12 000 g for 10 min and the supernatant was discarded.…”

Nanocarreadores aplicados ao tratamento do câncer de mama

“…A quimioterapia convencional tem a limitação devido à distribuição não seletiva de drogas anticâncer entre as células cancerígenas e as células saudáveis. (Maji, 2014;Pourjavadi, 2018). Com base nisso, o principal desafio do tratamento do câncer é a distribuição de substâncias tóxicas em locais específicos com efeito colateral mínimo em tecidos e órgãos saudáveis.…”