Delivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy

Manshadi, Mohammad Karim Dehghan; Saadat, Mahsa; Mohammadi, Mehdi; Shamsi, Milad; Dejam, Morteza; Kamali, Reza; Sanati‐Nezhad, Amir

doi:10.1080/10717544.2018.1497106

Cited by 103 publications

(43 citation statements)

References 56 publications

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“…It should be noticed that using the present method the particles that are coated with the anticancer drug are moving close to the desired trajectory and not close to the walls of the arteries as in [45]. This is very crucial since the particles moving near the wall may be trapped [46].…”

Section: Discussionmentioning

confidence: 95%

An Optimized Method for 3D Magnetic Navigation of Nanoparticles inside Human Arteries

Karvelas

Liosis

Theodorakakos

et al. 2021

Fluids

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A computational method for optimum magnetic navigation of nanoparticles that are coated with anticancer drug inside the human vascular system is presented in this study. For this reason a 3D carotid model is employed. The present model use Computational Fluid Dynamics (CFD) and Discrete Element Method (DEM) techniques along with Covariance Matrix Adaptation (CMA) evolution strategy for the evaluation of the optimal values of the gradient magnetic field. Under the influence of the blood flow the model evaluates the effect of different values of the gradient magnetic field in order to minimize the distance of particles from a pre-described desired trajectory. Results indicate that the diameter of particles is a crucial parameter for an effective magnetic navigation. The present numerical model can navigate nanoparticles with diameter above 500 nm with an efficiency of approximately 99%. It is found that the velocity of the blood seems to play insignificant role in the navigation process. A reduction of 25% in the inlet velocity leads the particles only 3% closer to the desired trajectory. Finally, the computational method is more efficient as the diameter of the vascular system is minimized because of the weak convective flow. Under a reduction of 50% in the diameter of the carotid artery the computational method navigate the particles approximately 75% closer to the desired trajectory. The present numerical model can be used as a tool for the determination of the parameters that mostly affect the magnetic navigation method.

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Section: Discussionmentioning

confidence: 95%

An Optimized Method for 3D Magnetic Navigation of Nanoparticles inside Human Arteries

Karvelas

Liosis

Theodorakakos

et al. 2021

Fluids

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“…The geometry and the distance of the magnet source is crucial to regulate their capability to manipulate NPs. To address this issue, employing of a permeant magnet inside or outside the body has been computationally suggested [ 56 , 185 , 201 , 233 , 242 ]. Further in vivo studies need to be implemented to identify the potential utility of a permanent magnet for effective magnetic drug delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Numerical simulations can provide a deep insight on effect of various MDT parameters such as particle diameter, flow rate of the blood in target vessels, position and strength of the magnet, gradient of the magnetic field, interaction of the particles and blood components, and trajectory of the particles in response to the magnet [ 65 , 188 , 189 ]. Manshadi et al [ 56 ] studied the effect of permanent magnet on the magnetic delivery of drug particles into artery tissues. For the first time, the four layers of the artery and their porosity were considered in the simulation to investigate the retention of drugs with the artery walls.…”

Section: Intravenous Magnetic Drug Targeting (Mdt) For Lung Cancersmentioning

confidence: 99%

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Magnetic particle targeting for diagnosis and therapy of lung cancers

Saadat

Manshadi

Mohammadi

et al. 2020

Journal of Controlled Release

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Over the past decade, the growing interest in targeted lung cancer therapy has guided researchers toward the cutting edge of controlled drug delivery, particularly magnetic particle targeting. Targeting of tissues by magnetic particles has tackled several limitations of traditional drug delivery methods for both cancer detection (e.g., using magnetic resonance imaging) and therapy. Delivery of magnetic particles offers the key advantage of high efficiency in the local deposition of drugs in the target tissue with the least harmful effect on other healthy tissues. This review first overviews clinical aspects of lung morphology and pathogenesis as well as clinical features of lung cancer. It is followed by reviewing the advances in using magnetic particles for diagnosis and therapy of lung cancers: (i) a combination of magnetic particle targeting with MRI imaging for diagnosis and screening of lung cancers, (ii) magnetic drug targeting (MDT) through either intravenous injection and pulmonary delivery for lung cancer therapy, and (iii) computational simulations that models new and effective approaches for magnetic particle drug delivery to the lung, all supporting improved lung cancer treatment. The review further discusses future opportunities to improve the clinical performance of MDT for diagnosis and treatment of lung cancer and highlights clinical therapy application of the MDT as a new horizon to cure with minimal side effects a wide variety of lung diseases and possibly other acute respiratory syndromes (COVID-19, MERS, and SARS).

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“…The numerical results of particle deposition fraction were shown to be in a good agreement with the data of previous work (Figure 1(b)). Moreover, the validity of the software for the simulation of magnetic field distribution around a permanent magnet was assessed in our previous study (Manshadi et al., 2018c).…”

Section: Methodsmentioning

confidence: 99%

Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet

et al. 2019

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Primary bronchial cancer accounts for almost 20% of all cancer death worldwide. One of the emerging techniques with tremendous power for lung cancer therapy is magnetic aerosol drug targeting (MADT). The use of a permanent magnet for effective drug delivery in a desired location throughout the lung requires extensive optimization, but it has not been addressed yet. In the present study, the possibility of using a permanent magnet for trapping the particles on a lung tumor is evaluated numerically in the Weibel's model from G0 to G3. The effect of different parameters is considered on the efficiency of particle deposition in a tumor located on a distant position of the lung bronchi and bronchioles. Also, the effective position of the magnetic source, tumor size, and location are the objectives for particle deposition. The results show that a limited particle deposition occurs on the lung branches in passive targeting. However, the incorporation of a permanent magnet next to the tumor enhanced the particle deposition fraction on G2 to up to 49% for the particles of 7 mm diameter. Optimizing the magnet size could also improve the particle deposition fraction by 68%. It was also shown that the utilization of MADT is essential for effective drug delivery to the tumors located on the lower wall of airway branches given the dominance of the air velocity and resultant drag force in this region. The results demonstrated the high competence and necessity of MADT as a noninvasive drug delivery method for lung cancer therapy. ARTICLE HISTORY

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Delivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy

Cited by 103 publications

References 56 publications

An Optimized Method for 3D Magnetic Navigation of Nanoparticles inside Human Arteries

An Optimized Method for 3D Magnetic Navigation of Nanoparticles inside Human Arteries

Magnetic particle targeting for diagnosis and therapy of lung cancers

Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet

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