Delivery of Renin Inhibitor Through Mouth Mucosa

Lu, Mou-Ying Fu; Hui, Ho-Wah

doi:10.3109/03639049609065954

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…[31] Different plasma concentration time curves were observed when solutions and patches were administered to different sites in a dog's mouth. [101] Therefore, it is highly recommended to exactly specify the site of administration to avoid undesired plasma concentration profiles.…”

Section: Biopharmaceuticsmentioning

confidence: 99%

Oromucosal film preparations: points to consider for patient centricity and manufacturing processes

Krampe

Visser²,

Frijlink³

et al. 2015

Expert Opinion on Drug Delivery

102

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The viscosity of the casting solution is a key factor for producing suitable films. This parameter is amongst others dependent on the polymer and active pharmaceutical ingredient, and the further excipients that are used. For optimal patient compliance, an acceptable taste and palatability are desirable. Safe and inert excipients should be used and appropriate packaging should be provided to produced films. Absorption through the oral mucosa will vary for each active compound, formulation and patient, which gives rise to pharmacokinetic questions. Finally, the European Pharmacopoeia needs to specify methods, requirement and definitions for oromucosal film preparations based on bio-relevant data.

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Section: Biopharmaceuticsmentioning

confidence: 99%

Oromucosal film preparations: points to consider for patient centricity and manufacturing processes

Krampe

Visser²,

Frijlink³

et al. 2015

Expert Opinion on Drug Delivery

102

View full text Add to dashboard Cite

show abstract

“…A number of animal models have been reported in the literature, however, very few in vivo (animal). Animal models such as the dog [23,24], rats [25], rabbits [26,27], cat [28], hamster [29,30], pigs [31], and sheep [32] have been reported. In general, the procedure involves anesthetizing the animal followed by administration of the dosage form.…”

Section: In Vivo Methodsmentioning

confidence: 99%

Magnetic Microspheres: A Novel Drug Delivery System

Farah

2016

JAPLR

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A well designed controlled drug delivery system can provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration for the specific period of time. A number of approaches are available in delivering therapeutic substance to the target site in sustained and controlled release fashion. One such approach is using magnetic microspheres as carriers for drugs. Microsphere drug delivery system has gained vast attention due to its diverse applications that range from targeting the drug to specific site to imaging and helping the diagnostic features.One of its important application is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposomes. The main objectives of this review are to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres.

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“…21 Magnetic particles with conjugated drugs are used to reach to the targeted region properly and deliver the drug for cancer treatment. [22][23][24] Another application involving magnetic microparticles is magnetic separation where magnetically labeled entities are removed from the nonmagnetic medium. With this approach, the extraction of tumor cells and separation of specific enzymes were achieved.…”

Section: Introductionmentioning

confidence: 99%

Feedback controller designs for an electromagnetic micromanipulator

Böyük

Eroğlu

Ablay

et al. 2019

Proceedings of the Institution of Mechanical Engineers, Part I:

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Magnetic micromanipulators are capable of generating wide range of magnetic forces to manipulate magnetic microparticles for biomedical applications. In this study, a multipole magnetic micromanipulator system including electromagnets, driver circuitry and control unit is designed, modeled and implemented. The micromanipulator can produce a broad range of magnetic forces up to 25 pN on a single magnetic microparticle (1–10 µm diameter) that is 5 mm away from the electromagnet core tip. Both linear and nonlinear controllers are designed and implemented, and the proposed nonlinear controller produces smooth control currents to assure closed-loop stability of the system with 1 s non-overshoot transient response and zero steady-state tracking error. The maximum output current of the driver circuitry is set to 1 A. The single particle at the center is moved at a speed of 5 mm/s. The fully automatic system can be utilized in applications related to single cell or microparticle manipulations.

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Delivery of Renin Inhibitor Through Mouth Mucosa

Cited by 4 publications

References 5 publications

Oromucosal film preparations: points to consider for patient centricity and manufacturing processes

Oromucosal film preparations: points to consider for patient centricity and manufacturing processes

Magnetic Microspheres: A Novel Drug Delivery System

Feedback controller designs for an electromagnetic micromanipulator

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