Delivery of Small-Molecule Drugs and Protein Drugs by Injectable Acid-Responsive Self-Assembled COF Hydrogels for Combinatorial Lung Cancer Treatment

Meng, Tao; Wang, Xinyue; Jiang, Shangshang; Chen, Si-rui; Zhou, Shengnan; Zhu, Yuheng; Wu, Jin; Hu, Danyou; Yan, Yuwen; Zhang, Guiyang

doi:10.1021/acsami.3c10074

Cited by 12 publications

(2 citation statements)

References 36 publications

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“…During in vivo antitumor therapy, the prepared drug‐delivery system surpassed the efficacy of free DOX and curcumin. Similarly, in 2023, Zhang et al [55] . modified COF‐1 linkages with RNase A via N→B bond formation.…”

Section: Covalent Functionalization Of Cofsmentioning

confidence: 98%

“…During in vivo antitumor therapy, the prepared drug-delivery system surpassed the efficacy of free DOX and curcumin. Similarly, in 2023, Zhang et al [55] modified COF-1 linkages with RNase A via N!B bond formation. The COF-1encapsulated RNase A was endocytosed by Lewis lung carcinoma cells, leading to intracellular RNA degradation and subsequent cell death.…”

Section: Linkagesmentioning

confidence: 99%

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Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Zhou,

Guan,

Dong

2023

Angew Chem Int Ed

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Nanomedicines are extensively used in cancer therapy. Covalent organic frameworks (COFs) are crystalline organic porous materials with several benefits for cancer therapy, including porosity, design flexibility, functionalizability, and biocompatibility. This review examines the use of COFs in cancer therapy from the perspective of reticular chemistry and function‐oriented materials design. First, the modification sites and functionalization methods of COFs are discussed, followed by their potential as multifunctional nanoplatforms for tumor targeting, imaging, and therapy by integrating functional components. Finally, some challenges in the clinical translation of COFs are presented with the hope of promoting the development of COF‐based anticancer nanomedicines and bringing COFs closer to clinical trials.

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Section: Covalent Functionalization Of Cofsmentioning

confidence: 98%

Section: Linkagesmentioning

confidence: 99%

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Zhou,

Guan,

Dong

2023

Angew Chem Int Ed

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Design of Porous Organic Polymer ASEIs for Zn Anode Protection and Ion Migration Regulation

Bian,

Xue,

Bin

et al. 2024

Adv Funct Materials

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Rechargeable aqueous Zn metal batteries (RAZMBs) are considered as a competitive alternative to the next generation of energy storage system. However, the Zn stripping/plating reversibility is greatly limited by the dendrite growth and the side reactions on Zn anode. In virtue of the excellent protection and ion migration regulation effects, porous organic polymer artificial solid electrolyte interphases (POPASEIs) have attracted widespread attention in stabilizing Zn anode. This article summarizes the progress of Zn anode POPASEIs in recent years, divided into two categories according to the polymer matrix: porous polymer‐based POPASEIs and nonporous polymer‐based POPASEIs. The porous polymer‐based POPASEIs can be divided into porous coordination organic polymer (PCOOP)‐based and porous covalent organic polymers (PCVOP)‐based ASEIs according to the chemical structure, while nonporous polymer‐based POPASEIs can be divided into four types according to the pore‐forming strategies, including phase separation‐induced POPASEIs, template‐assisted POPASEIs, fiber‐formed POPASEIs, porous filler‐modified POPASEIs. In addition, the structural advantages, challenges, and perspectives of POPASEIs for Zn anode are also discussed to provide guidance for the further research and development of Zn anode ASEIs.

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Responsive Multi‐Arm PEG‐Modified COF Nanocomposites: Dynamic Photothermal, pH/ROS Dual‐Responsive, Targeted Carriers for Rheumatoid Arthritis Treatment

Ge,

Wang,

Zhao

et al. 2024

Adv Healthcare Materials

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Rheumatoid arthritis (RA) is a chronic immune disease characterized by the infiltration of immune cells and the proliferation of fibroblast‐like synoviocytes (FLS) at the joint site, leading to inflammation and joint destruction. However, the available treatment options targeting both inflammatory and proliferative FLS are limited. Herein, this work presents three covalent organic frameworks (COFs) photothermal composite systems modified with multi‐armed polyethylene glycols (PEG) for the treatment of RA. These systems exhibit a dual response under low pH and high reactive oxygen species (ROS) conditions at the site of inflammation, with a specific focus on delivering the protein drug ribonuclease A (RNase A). Notably, molecular docking studies reveal the interaction between RNase A and NF‐κB p65 protein, and Western blotting confirm its inhibitory effect on NF‐κB activity. In vitro and in vivo experiments verify the significant reduction in joint swelling and deformities in adjuvant‐induced arthritis (AIA) rats after treatment with RNase A delivered by multi‐armed PEG‐modified COF ligands, restoring joint morphology to normal. These findings underscore the promising therapeutic potential of COFs for the treatment of RA, highlighting their unique capabilities in addressing both inflammatory and proliferative aspects of the disease and expanding the scope of biomedical applications for COFs.

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Delivery of Small-Molecule Drugs and Protein Drugs by Injectable Acid-Responsive Self-Assembled COF Hydrogels for Combinatorial Lung Cancer Treatment

Cited by 12 publications

References 36 publications

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Design of Porous Organic Polymer ASEIs for Zn Anode Protection and Ion Migration Regulation

Responsive Multi‐Arm PEG‐Modified COF Nanocomposites: Dynamic Photothermal, pH/ROS Dual‐Responsive, Targeted Carriers for Rheumatoid Arthritis Treatment

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