Delivery of soluble ethinylestradiol complex by <scp>pH</scp>‐responsive core‐shell composite hydrogel capsules

Gong, Fengrong; Jiang, Lihui; Gao, Yanni; Xu, Juan; Wang, Henan

doi:10.1002/app.54225

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…The core-shell hydrogel beads were created for the purpose of orally delivering insulin directly to the intestine using a chitosan-coated layered double hydroxides/insulin complex core and alginate shell, produced by a simple dropping method [6]. Core-shell hydrogel capsules were fabricated with a core of diethylenetriamine-β-cyclo-dextrin/ethinylestradiol, aldocellulose, hydroxyethylcellulose, and a shell of sodium alginate for sustained release of ethinylestradiol in the intestine [11].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Core-Shell Hydrogel Bead Based on Sodium Alginate and Chitosan for Methylene Blue Adsorption

Chen

2024

JRM

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A novel core-shell hydrogel bead was fabricated for effective removal of methylene blue dye from aqueous solutions. The core, made of sodium alginate-g-polyacrylamide and attapulgite nanofibers, was cross-linked by Calcium ions (Ca 2+ ). The shell, composed of a chitosan/activated carbon mixture, was then coated onto the core. Fourier transform infrared spectroscopy confirmed the grafting polymerization of acrylamide onto sodium alginate. Scanning electron microscopy images showed the core-shell structure. The core exhibited a high water uptake ratio, facilitating the diffusion of methylene blue into the core. During the diffusion process, the methylene blue was first adsorbed by the shell and then further adsorbed by the core. Adsorption tests showed that the coreshell structure had a larger adsorption capacity than the core alone. The shell effectively enhanced the adsorption capacity to methylene blue compared to the single core. Methylene blue was adsorbed by activated carbon and chitosan in the shell, and the residual methylene blue diffused into the core and was further adsorbed. KEYWORDSCore-shell structure hydrogel bead; attapulgite nanofiber; sodium alginate; polyacrylamide; methylene blue; adsorption materialResearch has focused on natural macromolecules such as cellulose, starch, chitin, and sodium alginate for their non-toxic, water-absorbing, biodegradable, and cost-effective properties in dye adsorption applications [3][4][5]. The core-shell structure of hydrogel beads, with distinct structures and properties in both the core and shell, has been studied for its versatility in applications like drug delivery, adsorption, and environmental cleanup [6,7].In drug delivery, sodium alginate is frequently used as a core or shell material due to its gelling ability with multivalent ions. Zhu reported a microsphere with a sodium alginate core incorporated with This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Core-Shell Hydrogel Bead Based on Sodium Alginate and Chitosan for Methylene Blue Adsorption

Chen

2024

JRM

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Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction

Wang,

Liu,

et al. 2024

J of Applied Polymer Sci

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As an efficient means of material carrying, multilayer capsules are widely used in medicine, agriculture, food safety and other fields. Here, we report a kind of temperature‐triggered multilayer capsule with chitosan‐sodium dodecyl benzene sulfonate (CS‐SDBS) as the shell and gelatin bead containing α‐cyclodextrin (α‐CD@gelatin) as the core. The α‐CD@gelatin/CS‐SDBS multilayer capsules can simultaneously encapsulate various substances, such as drugs, fluorescent materials, and nanoparticles. The encapsulated substances do not interfere with each other because they are located in different layers. Both the temperature‐sensitive property of gelatin and the host‐guest interaction between α‐CD and SDBS are utilized to achieve temperature‐controlled release of substances in the multilayer capsules. The release rate can be adjusted by the α‐CD amount in the gelatin beads. The controlled drug release and chemical detection of the multilayer capsules are studied with sodium salicylate, iodine, and purple cabbage pigment as the carriers. The results show that the α‐CD@gelatin/CS‐SDBS multilayer capsules have excellent capabilities of encapsulation and controlled release, which are beneficial for their application in the fields of substance encapsulation, drug‐controlled release, and chemical detection.

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Delivery of soluble ethinylestradiol complex by pH‐responsive core‐shell composite hydrogel capsules

Cited by 2 publications

References 47 publications

Fabrication of Core-Shell Hydrogel Bead Based on Sodium Alginate and Chitosan for Methylene Blue Adsorption

Fabrication of Core-Shell Hydrogel Bead Based on Sodium Alginate and Chitosan for Methylene Blue Adsorption

Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction

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