Delivery of surface-mediated non-viral gene nanoparticles from ultrathin layer-by-layer multilayers

An Anticoagulant Activity System Using Nanoengineered Autofluorescent Heparin Nanotubes

“…[14] The LbL assembly technique combined with the template membrane method of polyelectrolytes, biomacromolecules, and nanoparticles has seen extensive application in the fabrication of microcapsules and nanotubes. [3,[15][16][17][18] It has provided a convenient and economical method to prepare multilayer thin films over the last 20 years. Electrostatic interaction is one of the most common driving forces in the fabrication of polyelectrolyte multilayers.…”

Focus on polymer chemistry papers in Science China Chemistry of the year 2010

“…According to these papers one knows that the applications of biomedical polymers are focusing on drug release [4-8] and gene delivery [9,10]. For the drug release system, a great number of materials can be utilized such as supermolecule, block copolymers, hyperbranched polymers, etc.…”

“…Zhang et al discussed several kinds of stimulus-responsive nanoparticles, including pH-responsive, temperature-responsive, lightresponsive, magnetic-responsive, ultrasound-responsive, pH/ thermal-responsive, magnetic/(thermal or pH)-responsive, light/(thermal or pH)-responsive and triple-responsive nanoparticles [14]. Chen and Ji's goups prepared polycation-based gene nanoparticles [9,10,15]. A pH-sensitive shielding system, -benzyl L-glutamate-co-glutamate acid polymer (PGA(60), N,N′-cystaminebisacrylamide crosslinked polyethyleniine-poly(gamma-benzyl L-glutamate) (CPP), and the polycation-based gene nanoparticles modified lay-by-layer multilayers were fabricated for gene carriers.…”