Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems

Abstract

The use of nanoparticles is crucial for the development of a new generation of nanodevices for clinical applications. Silica-based nanoparticles can be tailored with a wide range of functional biopolymers with unique physicochemical properties thus providing several advantages: (1) limitation of interparticle interaction, (2) preservation of cargo and particle integrity, (3) reduction of immune response, (4) additional therapeutic effects and (5) cell targeting. Therefore, the engineering of advanced functional coatings is of utmost importance to enhance the biocompatibility of existing biomaterials. Herein we will focus on the most recent advances reported on the delivery and therapeutic use of silica-based nanoparticles containing biopolymers (proteins, nucleotides, and polysaccharides) with proven biological effects.

Recent Developments in Layer‐by‐Layer Assembly for Drug Delivery and Tissue Engineering Applications

“…Besides the acknowledged versatility offered by LbL assemblies, their main advantage lies in offering an efficient protection of antigens and adjuvants that they carry against enzymatic or physical degradation. [111] Moreover, LbL assemblies allow for incorporating a controlled amount of cargo at a relatively high density. [110] The following part will present several recent advances in the development of LbL-based vaccine delivery systems.…”

“…Vaccines are highly controlled medicines, and more storage, dosage, and safety studies must be carried out before they can be approved. [111]…”