Delphi definition of the EADC‐ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

Abstract

Background This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation. Methods The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher’s and binomial tests. Results Agreement was significant on the inclusion of alveus/fimbria (P =.021), whole hippocampal tail (P =.013), medial border of the body according to visible morphology (P =.0006), and on this combined set of features (P =.001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer’s disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates. Discussion Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

Systematic review of structural and functional brain alterations in psychosis of epilepsy

“…A harmonised protocol for hippocampal segmentation on magnetic resonance (HarP) has recently been developed as the gold standard method for hippocampal volumetry in Alzheimer’s disease 47. This protocol captures 100% of hippocampal tissue including the tail,48 and has high measurement stability. An example of manual hippocampal volumetry using the HarP protocol, which shows the extent of the hippocampus including the tail (traced by JA), is presented in figure 2.…”

Automatic thalamus and hippocampus segmentation from MP2RAGE: comparison of publicly available methods and implications for DTI quantification

“…Bilateral thalamus segmentation took 35-40 min per subject. The hippocampi were manually traced according to the EADC-ADNI segmentation protocol [19] by TA, initially supervised by EN. Segmentation of both hippocampi took 25-35 min per subject.…”

“…Segmentation of both hippocampi took 25-35 min per subject. As done in the EADC-ADNI protocol [19], all manual segmentations were performed in MNI space, where similar appearance of the nuclei is expected to improve tracing consistency and speed when using the segmentation protocols. The final segmentations were transformed back to scanner native space for comparison.…”

Hippocampal unified multi-atlas network (HUMAN): protocol and scale validation of a novel segmentation tool

“…The relative hippocampal labels were provided by the EADC-ADNI harmonized segmentation protocol 7 (Boccardi et al 2015a(Boccardi et al , 2015b were matched in terms of demographic and clinical composition. The volume distributions in the training set and test set were also matched, thus excluding any volume-based bias in the analysis.…”