Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells

Harada, Gakuro; Onoue, Shiori; Inoue, Chisato; Hanada, Sakae; Katakura, Yoshinori

doi:10.1007/s10616-018-0246-0

Cited by 17 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed several components in C. ternatea extracts could be acting synergistically. For instance, cyclotides which have been reported to have immunosuppressive properties may contribute (Gründemann et al, 2012, 2013; Thell et al, 2016), as could the abundance of delphinidins (Sogo et al, 2015; Tani et al, 2017; Harada et al, 2018).…”

Section: Historical and Current Applicationsmentioning

confidence: 99%

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

et al. 2019

View full text Add to dashboard Cite

The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant interest based on its agricultural and medical applications, which range from use as a fodder and nitrogen fixing crop, to applications in food coloring and cosmetics, traditional medicine and as a source of an eco-friendly insecticide. In this article we provide a broad multidisciplinary review that includes descriptions of the physical appearance, distribution, taxonomy, habitat, growth and propagation, phytochemical composition and applications of this plant. Notable amongst its repertoire of chemical components are anthocyanins which give C. ternatea flowers their characteristic blue color, and cyclotides, ultra-stable macrocyclic peptides that are present in all tissues of this plant. The latter are potent insecticidal molecules and are implicated as the bioactive agents in a plant extract used commercially as an insecticide. We include a description of the genetic origin of these peptides, which interestingly involve the co-option of an ancestral albumin gene to produce the cyclotide precursor protein. The biosynthesis step in which the cyclic peptide backbone is formed involves an asparaginyl endopeptidase, of which in C. ternatea is known as butelase-1. This enzyme is highly efficient in peptide ligation and has been the focus of many recent studies on peptide ligation and cyclization for biotechnological applications. The article concludes with some suggestions for future studies on this plant, including the need to explore possible synergies between the various peptidic and non-peptidic phytochemicals.

show abstract

Section: Historical and Current Applicationsmentioning

confidence: 99%

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

et al. 2019

View full text Add to dashboard Cite

show abstract

“…48 Palmitic acid, present in both species, has induced senescence in hepatocellular cells and also impairs the expression of the SMARCD1 gene, which appears to be responsible for the accumulation of lipids associated with aging in the hepatic cell. 49 Squalene and α-amyrin, together with other compounds present in Wrightia pubescens extracts, were effective against HT-29 (cell line colon) with an IC 50 of 1.70 μg mL −1 . 50 The compound β-amyrin showed cytotoxic effects against HCT-116 cells, and was the most active compound in Vicia monantha subsp.…”

Section: Cytotoxicitymentioning

confidence: 99%

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Guedes¹,

Filho²,

Silva³

et al. 2020

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds.

show abstract

“…Delphinidins inhibit adipogenesis and anti-obesity attributes 15,16 . Anthocyanidins have anti-cancer, anti-diabetic and anti-obesity properties 17 , and cyanidin-3-glucoside has also been reported to have good antioxidative capacity 18 .…”

Section: Introductionmentioning

confidence: 99%

Hibiscus sabdariffa extract as anti-aging supplement through its antioxidant and anti-obesity activities

et al. 2020

View full text Add to dashboard Cite

Introduction: Imbalance between total energy intake and expenditure causes accumulation of excess fat and sugar in the body which leads to development of diabetes mellitus type II, obesity, and metabolic syndrome. These harmful diseases accelerate aging and cause fatal metabolic disorders as people age. Inhibition of pancreatic lipase, and alpha glucosidase digestive enzymes is a step that can reduce excess fat and sugar from the body, which is an essential component of healthy aging. Methodology: In this study, aqueous and 50% ethanolic extracts of Hibiscus sabdariffa were investigated for their inhibitory activities on pancreatic lipase and alpha-glucosidase, in addition to their antioxidant activities (using UV-vis spectrophotometer). Results: Both extracts displayed antioxidant properties, indicated by IC50 of 5166.80 mg/mL for H. sabdariffa aqueous extract and 2809.10 mg/mL for H. sabdariffa 50% ethanolic extract. The extracts also suppressed the activities of pancreatic lipase and alpha-glucosidase enzymes, which suggests possible antiobesity and anti-diabetic activities. H. sabdariffa aqueous extract inhibited pancreatic lipase activity with IC50 of 167.5+/-12.7 mg/mL, whereas H. sabdariffa 50% ethanolic extract inhibited the enzyme with an IC50 of 790.65+/-16.02 mg/mL. Both H. sabdariffa aqueous and ethanolic extracts also successfully inhibited alpha-glucosidase enzyme activity with IC50 949.88 +/-10.83 mg/mL, and 378.33 +/-4.20 mg/mL, respectively. Conclusion: Taken together, the outcome of the investigations offers the possibility of the extracts as an anti-obesity, anti-diabetic, anti-metabolic and anti-aging agent, which can be developed into supplements for adults to prevent the occurrence of these prevalent diseases and delay the onset and effects of aging.

show abstract

Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells

Cited by 17 publications

References 13 publications

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Hibiscus sabdariffa extract as anti-aging supplement through its antioxidant and anti-obesity activities

Contact Info

Product

Resources

About