Delta-9-tetrahydrocannabinol (THC) history fails to affect THC's ability to induce place preferences in rats

Hempel, Briana; Wakeford, Alison G.P.; Clasen, Matthew M.; Friar, Mary A.; Riley, Anthony L.

doi:10.1016/j.pbb.2016.02.007

Cited by 23 publications

(18 citation statements)

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“…As noted above, Gatch and colleagues (2015) have previously reported CPP with α-PVP in mice; however, species differences in place preference conditioning have been noted with other drugs (see Chaperon et al, 1998; Cunningham et al, 1993; Hempel et al, 2016; Hutcheson et al, 1998; Saludo-Pena et al, 1997; Valjent and Maldonado, 2000). Accordingly, place preference conditioning was also assessed in the present experiment.…”

Section: Introductionmentioning

confidence: 90%

“…During habituation, training and testing (see below), animals were transferred to individual hanging, stainless-steel wire mesh test cages (24.3 × 19 × 18 cm) on the front of which graduated Nalgene tubes could be placed for fluid presentation. Eight identical three-chambered conditioned place preference systems (San Diego Instruments Place Preference System, San Diego, CA) were employed for place preference conditioning (for a detailed description, see Hempel et al, 2016). During training and testing, the procedure room was lit with an 85-watt red light mounted in the ceiling.…”

Section: General Methodsmentioning

confidence: 99%

“…Accordingly, place preference conditioning was also assessed in the present experiment. Specifically, rats were allowed access to a novel saccharin solution and injected with one of four doses of α-PVP (0, 0.3, 1.0 and 3.0 mg/kg) prior to being placed in a distinct environment, a procedure used by our laboratory (Hempel et al, 2016; King et al, 2015; Pomfrey et al, 2015; Simpson and Riley, 2005; Verendeev and Riley, 2011) and others (Brockwell et al, 1991; Sherman et al, 1980; Wang et al, 2010) to simultaneously assess the aversive (CTA) and rewarding (CPP) effects of a host of drugs of abuse.…”

Section: Introductionmentioning

confidence: 99%

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Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Nelson

Hempel

Clasen

et al. 2017

Pharmacology Biochemistry and Behavior

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Background α-pyrrolidinopentiophenone (α-PVP) has been reported to be rewarding in a variety of pre-clinical models. Given that a number of drugs of abuse have both rewarding and aversive effects, the balance of which influences addiction potential, the present study examined the aversive properties of α-PVP by assessing its ability to induce taste avoidance. This assessment was made in a combined taste avoidance/place conditioning design that also allowed an evaluation of the relationship between α-PVP’s aversive and rewarding effects. Methods Male Sprague-Dawley rats were exposed to a novel saccharin solution, injected with one of four doses of α-PVP (0, 0.3, 1.0 and 3.0 mg/kg) (IP) and placed on one side of a place conditioning apparatus. The next day, they were injected with vehicle, given access to water and placed on the other side. Following four conditioning cycles, saccharin avoidance and place preferences were then assessed. The effects of α-PVP on body temperature were also examined. Results α-PVP induced dose-dependent taste avoidance as well as significant increases in time spent on the drug-paired side (although this effect was not dependent on dose). α-PVP also induced dose- and time-dependent hyperthermia. Conclusions α-PVP induced significant taste avoidance whose strength relative to the psychostimulants methylenedioxypyrovalerone (MDPV) and cocaine paralleled their relative binding to the dopamine transporter. Similar to other drugs of abuse, α-PVP has both aversive and rewarding effects. It will be important to assess how various experiential and subject variables impact these effects and their balance to predict abuse liability.

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Section: Introductionmentioning

confidence: 90%

Section: General Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Nelson

Hempel

Clasen

et al. 2017

Pharmacology Biochemistry and Behavior

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“…A two-bottle choice test for a sweet liquid can be utilized to explore the role of drug administration on anhedonia, and saccharin a non-nutritive sweet liquid can be rewarding [67,68] CB1R-knockout on D1R expressing neurons mildly reduced sucrose preference [69]. THC administration induced a conditioned taste aversion to sucrose and saccharin [70][71][72]. However, the aversive nature of cannabinoids with regards to taste preference may be time dependent as pretreatment every other day for 12 days with THC attenuated the THC conditioned taste aversion to saccharin [71].…”

Section: Introductionmentioning

confidence: 99%

“…THC administration induced a conditioned taste aversion to sucrose and saccharin [70][71][72]. However, the aversive nature of cannabinoids with regards to taste preference may be time dependent as pretreatment every other day for 12 days with THC attenuated the THC conditioned taste aversion to saccharin [71]. Anhedonia-related behaviors may be associated with reductions in dopaminergic signaling as research using optogenetics has shown that antagonism of D1Rs in the NAc ablated basolateral amygdala to NAc excitation and inhibition of the basolateral amygdala to NAc pathway attenuated licking for a sucrose reward [73].…”

Section: Introductionmentioning

confidence: 99%

Indirect and Direct Cannabinoid Agonists Differentially Affect Mesolimbic Dopamine Release and Related Behaviors

Honeywell

Freels

McWain

et al. 2020

Preprint

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Abbreviations: 2-AG, 2-arachidonoylglycerol; AA-5-HT, N-arachidonoyl serotonin; ACEA, arachidinoyl-2'chloroethylamide; AEA, arachidonoylethanolamide; B6, C57BL/6J mice; CB1R, cannabinoid type 1 receptor; CB2R, cannabinoid type 2 receptor; CPA, conditioned place aversion; CPP, conditioned place preference; DAR, dopamine autoreceptor; DAT, dopamine transporter; D2R, dopamine receptor D2; D3R, dopamine receptor D3; eCB, endocannabinoid; EPM, elevated plus maze; FAB5, fatty acid binding protein-5; FAB7, fatty acid binding protein 7; FAAH, fatty acid amide hydrolase; LDB, light/dark box; MAGL, monoacylglycerol lipase; NAc, Nucleus accumbens; OF, open field, THC, Δ 9 -tetrahydracannabinol; TRPV1, transient receptor potential vanilloid type 1 channel; VTA, ventral tegmental area anad Highlights • The indirect cannabinoid agonist AA-5-HT did not alter dopamine release or measured behaviors.• The direct cannabinoid receptor agonist ACEA did not alter measured behaviors.• ACEA decreased dopamine release and the dopaminergic response to cocaine.• Neither drug indicated abuse liability, although ACEA did alter dopamine functioning. Abstract A major problem with current anxiolytic medications is abuse liability; thus, new pharmaceutical targets are being explored. The cannabinoid system is one potential target. The current paper examined behavioral and neurochemical changes related to abuse liability following chronic administration of the indirect cannabinoid agonist arachidonoyl serotonin (AA-5-HT) and the direct cannabinoid type 1 receptor (CB1R) agonist arachidonyl-2-chloro-ethylamide (ACEA). AA-5-HT indirectly agonizes the cannabinoid system via inhibition of the dual fatty acid amide hydrolase (FAAH) while also inhibiting transient vanilloid type 1 (TRPV1) channels. Neither AA-5-HT nor ACEA induced conditioned place preference (CPP) or altered behaviors during open field (OF) or saccharin preference testing. AA-5-HT did not alter phasic dopamine release in the nucleus accumbens, as measured with in vivo fixed potential amperometry; however, ACEA decreased dopamine release and enhanced the dopaminergic effect of cocaine. Overall, neither AA-5-HT nor ACEA induced behavioral or neurochemical changes associated with abuse liability; however, indirect mechanisms of agonizing the cannabinoid system may be a better alternative than direct mechanisms if concerned with disrupting dopamine function.

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Molecular Mechanism and Cannabinoid Pharmacology

Schurman

Kendall

et al. 2019

Handbook of Experimental Pharmacology

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Delta-9-tetrahydrocannabinol (THC) history fails to affect THC's ability to induce place preferences in rats

Cited by 23 publications

References 61 publications

Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Indirect and Direct Cannabinoid Agonists Differentially Affect Mesolimbic Dopamine Release and Related Behaviors

Molecular Mechanism and Cannabinoid Pharmacology

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