delta-Aminolevulinic Acid and Blue Light Photodynamic Therapy for Treatment of Multiple Basal Cell Carcinomas in Two Patients with Nevoid Basal Cell Carcinoma Syndrome

Abstract

To our knowledge this is the first use of photodynamic therapy with delta-aminolevulinic acid with 417-nm blue light for treatment of multiple basal cell carcinomas in patients with nevoid basal cell carcinoma syndrome. Our clinical results demonstrate that the blue light reduces cutaneous tumor burden in such patients. Further studies are needed to confirm that broad-area photodynamic therapy with delta-aminolevulinic acid may eradicate subclinical tumors in nevoid basal cell carcinoma syndrome sufferers, as suggested by a strikingly decreased incidence of new basal cell carcinomas in our patients.

Photodynamic Therapy in Skin Cancer

“…To reduce the pain, general anesthesia may be used, most often when treating children or extensive lesions, or local anesthesia and also premedication with opioids. However, the latter proved inefficient (Itkin &Gilchrest, 2004;Oseroff, 2005). The results of PDT are estimated by the disappearance of the tumor, this occurs normally after 2-3 days.…”

Terapia fotodinâmica para tratamento de múltiplas lesões no couro cabeludo na síndrome do nevobasocelular: relato de caso

“…Protoporphyrin IX is metabolised in heme, as it becomes photodynamically inactive within 24 to 48 hours. 4 The most common adverse effects are phototoxical reactions,described as burning sensation during the treatment and erythema, persisiting for more than 7 days. Pigmentary alterations are rare and, when they occur, they have short duration.…”

“…It is characterized by the appearing of multiple CBC in precocious age and many stigmas of abnormal development. 4 FDT is a therapeutic option which offers excellent or good esthetic results, 1 that is particularly important when BCC is concerned as it is a neoplasia more frequently found in relatively young patients, such as, the carriers of the Nevoid Basal Cell Syndrome.…”

“…4 Dermatologist, member of the Brazilian Society of Dermatology -Belo Horizonte -(MG), Brazil. 5 Dermatologist, member of the Brazilian Society of Dermatology -Belo Horizonte -(MG), Brazil.…”

Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico

“…O MAL também é aprovado nos Estados Unidos no tratamento da queratose actinica com luz vermelha 119,132 .…”