Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

Han, In Mi; Yoon, Chang Yun; Shin, Dong Ho; Kee, Youn Kyung; Han, Seung Gyu; Kwon, Young Eun; Park, Kyoung Sook; Lee, Mi Jung; Oh, Hyung Jung; Park, Sun-Hee; Han, Seung Hyeok; Kang, Shin Wook; Yoo, Tae Hyun

doi:10.1186/s12882-017-0507-8

Cited by 8 publications

(10 citation statements)

References 43 publications

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“…In evaluating septic conditions, the DNI is therefore more valuable than the leucocyte count as it reflects the circulating immature granulocyte count irrespective of the leucocyte count 45 . Additionally, several studies have found that the DNI has the advantages of accuracy and rapidity in evaluating infection 22 , 23 , 39 . Hence, although the DNI is not widely used, these characteristics and advantages motivated us to evaluate further its value as a clinical prognostic biomarker.…”

Section: Discussionmentioning

confidence: 99%

The delta neutrophil index (DNI) as a prognostic marker for mortality in adults with sepsis: a systematic review and meta-analysis

Ahn

Kim

Lim

et al. 2018

Sci Rep

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We performed a meta-analysis to seek evidence for the usefulness of the delta neutrophil index (DNI) as a prognostic blood biomarker for mortality in the early stage of sepsis in adults. A literature search was performed using criteria set forth in a predefined protocol. Studies of adults with sepsis that provided a DNI measurement and that had mortality as the outcome, were included. Review articles, editorials, and non-human studies were excluded. The methodological quality of identified studies was assessed independently by two authors using the Quality in Prognosis Studies (QUIPS) tool. A total of 1,822 patients from eleven studies were ultimately included. Standardized mean differences between non-survivors and survivors were compared. An elevated DNI was associated with mortality in patients with sepsis (standardized mean difference [SMD] 1.22; 95% confidence interval 0.73–1.71; I2 = 91%). After excluding two studies—one that included paediatric patients and one with a disproportionately low mortality rate—heterogeneity was minimized (SMD 0.74, 95% confidence interval 0.53–0.94; I2 = 43%). Overall, the findings suggest that high DNI values are associated with mortality in septic patients.

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Section: Discussionmentioning

confidence: 99%

The delta neutrophil index (DNI) as a prognostic marker for mortality in adults with sepsis: a systematic review and meta-analysis

Ahn

Kim

Lim

et al. 2018

Sci Rep

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“…According to recent studies, DNI is a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes . A higher DNI is a prognostic marker of out‐of‐hospital cardiac arrest and an independent factor of mortality in septic acute kidney injury patients with continuous renal replacement therapy . Septic condition of patients who visited the emergency room is an important factor for predicting their prognosis and mortality.…”

Section: Discussionmentioning

confidence: 99%

“…13 A higher DNI is a prognostic marker of out-of-hospital cardiac arrest 14 and an independent factor of mortality in septic acute kidney injury patients with continuous renal replacement therapy. 15 Septic condition of patients who visited the emergency room is an important factor for predicting their prognosis and mortality. Therefore, there have been efforts to find proper biomarkers associated with sepsis.…”

Section: Discussionmentioning

confidence: 99%

Delta neutrophil index as a prognostic marker in emergent abdominal surgery

Soh

Lim

2019

Clinical Laboratory Analysis

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BackgroundDelta neutrophil index (DNI) is the fraction of circulating immature granulocytes provided by a routine, complete blood cell analyzer. It is known to be a useful prognostic marker of sepsis. The aim of this study was to evaluate the role of DNI in the diagnosis and prognosis of patients who had undergone emergent surgery for an acute abdomen.MethodsA total of 694 patients who had visited the emergency room for acute abdominal pain and undergone emergent abdominal surgery from May 2015 to September 2016 were retrospectively reviewed. Clinical characteristics, laboratory findings on the day of hospital visit, hospital stay, postoperative complications, and 30‐day mortality were investigated.ResultsIn the analysis of patients who had undergone an operation for acute peritonitis, the DNI was a good predictor for predicting 30‐day mortality rate (area under the curve [AUC]: 0.826). It was not inferior to other laboratory values, including activated partial thromboplastin time (AUC: 0.729), C‐reactive protein (AUC: 0.727), albumin (AUC: 0.834), prothrombin time (AUC: 0.816), and creatinine (AUC: 0.837) known to be associated with sepsis. Patients with high DNI displayed higher incidence of bacteremia and sepsis, longer hospital stay, higher postoperative complication rate, and higher 30‐day mortality rate than patients with low DNI. Among patients diagnosed with acute appendicitis, the DNI was a useful marker for differentiating appendiceal perforation.ConclusionThe DNI was a practical and useful marker for predicting the prognosis of patients who needed emergent abdominal surgery.

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“…To our knowledge, this is the first study showing a relationship between PCO 2 and the outcomes of patients treated with CRRT. Previous studies related to the predictive factors for survival renal recovery of the critically ill patients receiving CRRT focused on status of fluid, serum creatinine, glomerular filtration rate [10, 14, 15], coagulation functions [7, 16], inflammatory related mediators [5], and electrolyte and mineral disturbances [6]. However, there were few studies investigating parameters from respiratory system predicting survival with CRRT therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Both patient status and CRRT modality will affect patient outcomes. Some of cohort tried to find out the relationship of CRRT-related variables and hospital mortality [2-4], and several patient-related biomarkers have been investigated to be associated with mortality of CRRT patients [5-10]. With the improvement of techniques and methods of CRRT, indications of CRRT were far more than renal dysfunction.…”

mentioning

confidence: 99%

Prognostic Factors and Efficacy for Continuous Renal Replacement Therapy in Critically Ill Patients: A Chinese Single-Center Retrospective Study

Zhang¹,

Li²,

Peng³

2017

Blood Purif

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Background: There is controversy about the efficacy and prognostic factors for continuous renal replacement therapy (CRRT) in China due to practice variation. Our aim is to investigate these questions. Method: A total of 613 adult patients receiving CRRT in last 3 years from one Chinese ICU were enrolled. The analysis of demographic data, vital signs, and laboratory tests prior to CRRT and outcomes were performed. The data between pre- and post-CRRT were compared for efficacy analysis. Results: Prior to CRRT, partial pressure of carbon dioxide (PCO₂), systolic blood pressure (SBP), gender, age, bilirubin, cystatin C, and mechanical ventilation were correlated with in-hospital mortality. In a binary logistic regression, PCO₂, SBP, age, and gender were significant in predicting mortality. Cox regression analysis demonstrated PCO₂ independent association with mortality, and lower SBP worse mortality. CRRT could eliminate the fluid and metabolites. Conclusion: CO₂ retention and low SBP prior to CRRT were associated with increased mortality. CRRT significantly improved hemeostasis.

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Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

Cited by 8 publications

References 43 publications

The delta neutrophil index (DNI) as a prognostic marker for mortality in adults with sepsis: a systematic review and meta-analysis

The delta neutrophil index (DNI) as a prognostic marker for mortality in adults with sepsis: a systematic review and meta-analysis

Delta neutrophil index as a prognostic marker in emergent abdominal surgery

Prognostic Factors and Efficacy for Continuous Renal Replacement Therapy in Critically Ill Patients: A Chinese Single-Center Retrospective Study

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