2017
DOI: 10.1016/j.asd.2016.11.007
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Delta-Notch signalling in segmentation

Abstract: Modular body organization is found widely across multicellular organisms, and some of them form repetitive modular structures via the process of segmentation. It's vastly interesting to understand how these regularly repeated structures are robustly generated from the underlying noise in biomolecular interactions. Recent studies from arthropods reveal similarities in segmentation mechanisms with vertebrates, and raise the possibility that the three phylogenetic clades, annelids, arthropods and chordates, might… Show more

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Cited by 61 publications
(53 citation statements)
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References 233 publications
(311 reference statements)
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“…In all vertebrates examined to date, at least one Notch pathway component or target exhibits cyclic expression, linking Notch activation to clock function (Liao and Oates, 2016). However, the specific Notch pathway components that oscillate in the clock vary among species.…”
Section: Introductionmentioning
confidence: 99%
“…In all vertebrates examined to date, at least one Notch pathway component or target exhibits cyclic expression, linking Notch activation to clock function (Liao and Oates, 2016). However, the specific Notch pathway components that oscillate in the clock vary among species.…”
Section: Introductionmentioning
confidence: 99%
“…As the most highly conserved pathway involved in the segmentation clock, a wealth of studies have focused on elucidating the fundamental role of Notch in somitogenesis and in the segmentation clock mechanism (Barrantes et al, 1999; Jiang et al, 2000; Bessho et al, 2001b, 2003; Dale et al, 2003; Julich et al, 2005; McGrew et al, 2008; Hubaud and Pourquie, 2014; Wahi et al, 2014; Liao and Oates, 2016). Notch is clearly required to synchronize oscillations between neighboring cells (Jiang et al, 2000; Shimojo et al, 2016).…”
Section: Somitogenesismentioning
confidence: 99%
“…A question that arises is whether oscillations are actually necessary for the segmentation process to occur or whether just non-oscillatory activity of the Notch pathway is sufficient. Mutant mice or fish lacking Notch components all display severe segmentation defects (Conlon et al, 1995; Barrantes et al, 1999; Jiang et al, 2000; Liao and Oates, 2016). For example, the lack of the obligate transcription factor RBP-J κ, in mouse, leads to lethality before day E10.5 and only the first few cervical somites are formed (Oka et al, 1995).…”
Section: Somitogenesismentioning
confidence: 99%
“…Synchronization of clock gene oscillations between neighbouring cells is reliant on Notch signalling [10][11][12][13]. Synchronization of clock gene oscillations between neighbouring cells is reliant on Notch signalling [10][11][12][13].…”
Section: Introductionmentioning
confidence: 99%