Deltamethrin modulates the native structure of Hen Egg White Lysozyme and induces its aggregation at physiological pH

Varma, Neelakant; Singh, Abhishek; Ravi, Vijay; Thakur, Mukesh; Kumar, Satish

doi:10.1016/j.colsurfb.2021.111646

Colloids and Surfaces B: Biointerfaces

2021

DOI: 10.1016/j.colsurfb.2021.111646

|View full text |Cite

Deltamethrin modulates the native structure of Hen Egg White Lysozyme and induces its aggregation at physiological pH

Neelakant Varma¹,

Abhishek Singh

Vijay Ravi

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2024

Publication Types

Select...

Article5

Relationship

Self Cite1

Independent4

Authors

Journals

Cited by 6 publications

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Benzoylmesaconine alters the native structure and activity of hen egg white lysozyme: revealing possible mechanism of aconitum-induced toxicity

Marycleopha,

Johnson,

Singh

et al. 2024

Forensic Toxicol

View full text Add to dashboard Cite

Benzoylmesaconine alters the native structure and activity of hen egg white lysozyme: revealing possible mechanism of aconitum-induced toxicity

Marycleopha,

Johnson,

Singh

et al. 2024

Forensic Toxicol

View full text Add to dashboard Cite

PVP-AuNP Impedes Glycation Mediated Hen Egg White Lysozyme Aggregation Under Physiological Condition

Johnson,

Tyagi,

Maity

et al. 2024

BioNanoSci.

Self Cite

View full text Add to dashboard Cite

Protein glycation a non-enzymatic protein modi cation, alters the structure of biomolecule leading to several neurodegenerative and other disorders. As onset of disorders due to protein glycation is primarily driven by the development of advanced glycation end products (AGEs), therapeutic intervention against related disorders by inhibiting AGEs production is imperative. Nanoparticles have recently gained more prominence as therapeutic agents in biological eld such as medicine, drug discovery and diagnosis. In present study, we extensively investigated the effect of chemically synthesized polyvinylpyrrolidone conjugated gold nanoparticles (PVP-AuNP) on D-ribose induced glycation of hen egg white lysozyme (HEWL) under physiological conditions. Our nding shows that AGEs formation was inhibited by PVP-AuNP over the period of 20 days. Interaction of gold nanoparticles prevented glycation induced misfolding and aggregation of lysozyme by stabilizing its native structure, which was evident with static light scattering, ThT, Congo red and ANS uorescence coupled with CD spectroscopy. Further, by estimating carbonyl content and thiol group, our study suggests that PVP-AuNP possesses antioxidant property thus prevent the HEWL against glycation driven oxidative damage. Present study therefore elucidates that PVP-AuNP a signi cant antiglycation agent can be used against wide range of disorders induced by AGEs.

show abstract

Submicron-size polystyrene modulates amyloid fibril formation: From the perspective of protein corona

Chen

Liu

Yang

et al. 2022

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Deltamethrin modulates the native structure of Hen Egg White Lysozyme and induces its aggregation at physiological pH

Cited by 6 publications

References 54 publications

Benzoylmesaconine alters the native structure and activity of hen egg white lysozyme: revealing possible mechanism of aconitum-induced toxicity

Benzoylmesaconine alters the native structure and activity of hen egg white lysozyme: revealing possible mechanism of aconitum-induced toxicity

PVP-AuNP Impedes Glycation Mediated Hen Egg White Lysozyme Aggregation Under Physiological Condition

Submicron-size polystyrene modulates amyloid fibril formation: From the perspective of protein corona

Contact Info

Product

Resources

About