Deltoid flap combined with fascia lata autograft for rotator cuff defects: a histologic study

Abstract

The purpose of this study was to compare the histological characteristics of an autogenous fascia lata graft alone and a fascia lata graft combined with a deltoid flap in the reconstruction of rotator cuff tears. Ten New Zealand white rabbits were divided into two groups. Infraspinatus tendon defects (1 x 1 cm) were created in each animal. Reconstruction consisted of either a fascia lata graft alone or a fascia lata graft combined with a distally based deltoid flap. At 3 months, tissue harvest and histological analysis was performed. Compared to the fascia lata graft alone, there was significantly increased remodeling activity and neovascularization in the group that included a deltoid flap. Also, there was pronounced interdigitation at the graft/flap interface in the latter group. A mutually beneficial relationship may exist when an autogenous fascial graft is combined with a functional deltoid flap for reconstructing large rotator cuff defects.

Extracellular matrix scaffold devices for rotator cuff repair

“…Most of these studies used an ECM scaffold for rotator cuff tendon interpositional grafting, 1,16,20,48,57,65,82 and 2 studies report on the use of ECM grafts for rotator cuff repair augmentation. 55,66 Because most ECM scaffolds have been cleared by the FDA only for rotator cuff repair augmentation (ie, the scaffold is applied over the primary tendon repair), only the animal studies investigating this indication will be reviewed here.…”

Preclinical Models for Translating Regenerative Medicine Therapies for Rotator Cuff Repair

“…To some extent, both of these issues in large animals confound our conclusion on the mechanical effectiveness of various repair strategies for the human condition. As well, large animals have been used to study regenerative strategies for acute tendonto-bone healing using growth factors, 25,89 scaffold interposition, 42,59,75,[90][91][92] and scaffold augmentation. 65,76,93 Large animal models have been used to a lesser extent to study chronic rotator cuff repair 54,63,64,67,68 as the tendons become irreparable to their anatomic footprint after approximately 6 weeks, resulting from excessive tendon retraction and muscle atrophy and stiffening.…”

Autologous fascial slings remain viable at long-term follow-up: a post cystectomy case report

“…Animal models can provide useful information on how to integrate autologous tissues in the treatment of SUI or on which they can be most effective. McAdams et al hypothesized that there may be a benefit in combining an autologous fascial graft and a deltoid flap into murine models [11].…”