Demand Analgesia to Assess Pain Relief From Epidural Opiates

McQuay, Henry J; Bullingham, R. E. S.; Evans, Peter; Lloyd, Julia; Moore, R Andrew

doi:10.1016/s0140-6736(80)91263-5

Cited by 36 publications

(11 citation statements)

References 6 publications

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“…IVPCA was used as a measure of the analgesic efficacy of epidural morphine, with lower postoperative IVPCA opioid requirement indicating greater analgesic effect from the epidural morphine. 23 The joint use of these two analgesic strategies would be unlikely in clinical practice, but what we have are data that potentially illuminate aspects of postoperative pain care.…”

Section: Discussionmentioning

confidence: 98%

“…IVPCA was being used as a measure of analgesic efficacy. 23 Records were kept of subjects who were converted to oral analgesia within the first 48 h or who received other opioid analgesia for any reason. Non-fentanyl opioids were incorporated into the total consumption calculations for analysis as 'fentanyl equivalents'; 24 totals at 24 and 48 h were available for each patient.…”

Section: Methodsmentioning

confidence: 99%

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Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain

Mhuircheartaigh¹,

Moore²,

McQuay

2009

British Journal of Anaesthesia

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Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain

Mhuircheartaigh¹,

Moore²,

McQuay

2009

British Journal of Anaesthesia

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Section: Discussionmentioning

confidence: 99%

The effect of intravenous tenoxicam on pruritus in patients receiving epidural fentanyl

Colbert¹,

O’Hanlon²,

Chambers³

et al. 1999

Anaesthesia

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In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery during which epidural fentanyl was administered. All patients had an epidural catheter inserted at the time of surgery. Epidural fentanyl 100 micrograms was administered intra-operatively and infused at a concentration of 2 micrograms.ml-1 for 48 h postoperatively. All patients received a standard anaesthetic and, in addition, the study group had a 20 mg bolus of tenoxicam intravenously, intra-operatively. Patients receiving tenoxicam demonstrated significantly lower pruritus and pain scores at 30 min, 2, 4, 8 and 24 h postoperatively as well as reduced pethidine requirements for breakthrough pain in the first 24 h. In conclusion, tenoxicam 20 mg significantly reduces the incidence and severity of postoperative pruritus in patients who received peri-operative epidural fentanyl. In addition, it significantly reduces pain and further analgesic requirements postoperatively.

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“…It has been implied that the preservative in which spinal opioids are delivered contributes to the pruritus but this theory has not been validated. This concern has led to the removal of these preservatives from such solutions, but this has not influenced the experience of pruritus [21,26]. Opioids, which are clinically important pruritogens, probably act firstly by releasing histamine and secondly by stimulating a central encephalinergic mechanism [27,28].…”

Section: Discussionmentioning

confidence: 99%

Anaesthesia for daycase gynaecological laparoscopy: a survey of clinical practice in the United Kingdom

Simpson¹,

Russell

1999

Anaesthesia

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SummaryGynaecological laparoscopy is a daycase procedure that can be associated with significant morbidity and patients may require admission to hospital for overnight stay. Following a decision to administer intraperitoneal bupivacaine routinely to such patients in our day surgery unit, we wished to establish whether this was routine practice elsewhere. We therefore carried out a postal survey of consultant anaesthetists in the UK who regularly anaesthetise patients undergoing daycase gynaecological laparoscopy, addressing a number of clinical issues. The results of the survey are presented, discussed and compared with published advice.

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Demand Analgesia to Assess Pain Relief From Epidural Opiates

Cited by 36 publications

References 6 publications

Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain

Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain

The effect of intravenous tenoxicam on pruritus in patients receiving epidural fentanyl

Anaesthesia for daycase gynaecological laparoscopy: a survey of clinical practice in the United Kingdom

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