Many control algorithms have been applied to manage the flow of products in supply chains. However, in the era of thriving globalization, even a small disruption can be fatal for some companies. On the other hand, the rising environmental impact of a rapid industry is imposing limitations on energy usage and waste generation. Therefore, taking into account the mentioned perspectives, there is a need to explore the research directions that concern product perishability together with different demand patterns and their uncertain character. This study aims to propose a robust control approach that combines neural networks and optimal controller tuning with the use of both different demand patterns and fuzzy logic. Firstly, the demand forecast is generated, following which the parameters of the neural controller are optimized, taking into account the different demand patterns and uncertainty. As part of the verification of the designated controller, the sensitivity to parameter changes has been determined using the OAT method. It turns out that the proposed approach can provide significant waste reductions compared to the well-known POUT method while maintaining low stocks, a high fill rate, and providing lower sensitivity for parameter changes in most considered cases. The effectiveness of this approach is verified by using a dataset from a worldwide retailer. The simulation results show that the proposed approach can effectively improve the control of uncertain perishable inventories.