Demands on scientific studies in clinical toxicology

Maurer, Hans H.

doi:10.1016/j.forsciint.2006.05.019

Cited by 28 publications

(22 citation statements)

References 37 publications

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“…Drug screening also was positive for tricyclic antidepressants, although the use of immunoassays is limited, because different drugs of the corresponding group may have quite different cross reactivity and/or pharmacological potency [27]. …”

Section: Discussionmentioning

confidence: 99%

Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide: Pharmacological Concerns of Side Effects

Muller

Réuter

Dohmen

2009

Case Reports in Medicine

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Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QTc-prolongation, somnolence, and hyperglycemia. Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old female (62 kg bodyweight) to attempt suicide. Symptoms associated with intoxication were coma without arterial hypotension, persistent tachycardia, hyperglycemia, and transient hypothyreoidism. QTc-interval was moderately extended. Management consisted of intubation for airway protection, gastric lavage, the use of activated charcoal, i.v. saline, and observation for 17 hours on an intensive care unit. Despite the extremely high dose of quetiapine, the patient recovered completely without residual symptoms.

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Section: Discussionmentioning

confidence: 99%

Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide: Pharmacological Concerns of Side Effects

Muller

Réuter

Dohmen

2009

Case Reports in Medicine

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“…This is a prerequisite for evidence-based case interpretation, which may have important impact in the clinical or forensic consequences and outcome (Maurer 2007). At moment, LC-LRMS/MS is the mostly applied technique for (multi-target) quantification (Meyer et al 2014a;Patteet et al 2015;.…”

Section: Quantification Of Pharmaceuticals Doa and Toxinsmentioning

confidence: 99%

High-resolution mass spectrometry in toxicology: current status and future perspectives

Maurer

Meyer

2016

Arch Toxicol

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This paper reviews high-resolution mass spectrometry (HRMS) approaches using time-of-flight or Orbitrap techniques for research and application in various toxicology fields, particularly in clinical toxicology and forensic toxicology published since 2013 and referenced in PubMed. In the introduction, an overview on applications of HRMS in various toxicology fields is given with reference to current review articles. Papers concerning HRMS in metabolism, screening, and quantification of pharmaceuticals, drugs of abuse, and toxins in human body samples are critically reviewed. Finally, a discussion on advantages as well as limitations and future perspectives of these methods is included.

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“…• Elucidation of metabolite structures in drug metabolism studies (Meyer and Maurer 2012;Castaneto et al 2015) • Studies of pharmacokinetics (Richter et al 2016;Wink et al 2016) • Screening for pharmaceuticals, drugs of abuse and toxins, making use of the flexibility of HRMS to add further compounds easily to existing screening approaches (Peters 2014;Patteet et al 2015) • Quantification of pharmaceuticals, drugs of abuse and toxins, where a reliable quantification is required for clinical decisions or forensic consequences (Maurer 2007). Here, LC-HRMS/MS has become the most applied technique for multi-target quantification (Meyer et al 2014;Meyer and Maurer 2016 …”

Section: Referencesmentioning

confidence: 99%

Highlight report: high-resolution mass spectrometry

Blaszkewicz

2016

Arch Toxicol

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Demands on scientific studies in clinical toxicology

Cited by 28 publications

References 37 publications

Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide: Pharmacological Concerns of Side Effects

Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide: Pharmacological Concerns of Side Effects

High-resolution mass spectrometry in toxicology: current status and future perspectives

Highlight report: high-resolution mass spectrometry

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