Dementia after DBS Surgery: A Case Report and Literature Review

Rektorová, Irena; Hummelová, Zuzana; Baláž, Marek

doi:10.4061/2011/679283

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Therefore cognitive changes and the predictors for such changes are still a matter of debate. [ 3 6 8 9 10 12 14 17 19 28 32 37 38 42 43 44 48 49 51 52 ] We had already demonstrated an improved performance of executive functions, complex motion sequences, and complex reaction time shortly after DBS. [ 13 ] The aim of our present study was to assess cognitive outcome in PD patients by a standardized performance of a neuropsychological test battery following STN DBS after an interval of at least several months lasting interval.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological effects of deep brain stimulation for Parkinson′s disease

Harati

Müller

2013

Surg Neurol Int

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Background:Putative changes of cognition after deep brain stimulation (DBS) in patients with Parkinson's disease (PD) are a matter of debate. The aim of this study was to assess cognitive abilities before and following bilateral subthalamic nucleus (STN) DBS and to review the available literature.Methods:Twenty patients underwent bilateral DBS of the STN. Cognitive skills were assessed in a standardized fashion before and at least at 12 months after the surgical intervention.Results:There was a significant decline of both semantic and phonematic verbal fluency and a mild trend for a deterioration of verbal memory after DBS. Mood, general cognitive screening, and visospatial abilities remained unchanged.Conclusion:STN DBS in the treatment of PD has resulted in a significant reduction of motor symptoms and improved independence and quality of life in appropriately selected patients. However, it may have isolatable effects on verbal fluency and related function. Case series in the literature reported similar findings. Potential candidates for DBS should be counseled about the risk of mild cognitive declines.

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Section: Introductionmentioning

confidence: 99%

Neuropsychological effects of deep brain stimulation for Parkinson′s disease

Harati

Müller

2013

Surg Neurol Int

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“… 33 Small Intracerebral hemorrhage, as a possible adverse event, may accelerate the development of dementia and since age seems to be the major risk factor, it has been suggested to exclude PD patients above 70 years of age for DBS surgery. 34 …”

Section: Discussionmentioning

confidence: 99%

A Long Term Effects of a New Onset Psychosis after DBS Treated with Quetiapine in a Patient with Parkinson's Disease

Piccoli¹,

Perini²,

Pizzighello³

et al. 2015

Psychiatry Investig

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Deep Brain Stimulation represents a therapeutic option for PD patients. In this paper, we present and discuss a case of acute delirium and psychosis manifesting after DBS in a 58-years-old man affected by Parkinson's Disease. We highlight the importance of an exhaustive psychiatric evaluation in candidates for DBS and we underline the severity and non-reversibility of some adverse events associated with the implantation, suggesting the use of Quetiapine in the management of these effects. Acute psychosis may be listed as a potential severe adverse event associated with DBS, even in patients without a clear cut previous history of psychiatric disorders.

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“…While dementia is part of the natural progression of the disease, surgery likely plays a precipitating role. Cases have been reported of immediate postoperative cognitive decline following STN-DBS, often associated with suboptimally placed leads [ 41 , 42 ]. At UTSW, we have identified two such patients who presented with disabling cognitive symptoms soon after DBS [ 43 ].…”

Section: Comparison Of the Target Sitesmentioning

confidence: 99%

Comparison of Globus Pallidus Interna and Subthalamic Nucleus in Deep Brain Stimulation for Parkinson Disease: An Institutional Experience and Review

Mirza

Yazdani

Patel

et al. 2017

Parkinson's Disease

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Deep Brain Stimulation (DBS) has revolutionized the lives of patients of Parkinson disease, offering therapeutic options to those not benefiting entirely from medications alone. With its proven track record of outperforming the best medical management, the goal is to unlock the full potential of this therapy. Currently, the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN) are both viable targets for DBS, and the choice of site should focus on the constellation of symptoms, both motor and nonmotor, which are key determinants to quality of life. Our article sheds light on the specific advantages and drawbacks of the two sites, highlighting the need for matching the inherent properties of a target with specific desired effects in patients. UT Southwestern Medical Center has a robust and constantly evolving DBS program and the narrative from our center provides invaluable insight into the practical realities of DBS. The ultimate decision in selecting a DBS target is complex, ideally made by a multidisciplinary team, tailored towards each patient's profile and their expectations, by drawing upon scientific evidence coupled with experience. Ongoing research is expanding our knowledge base, which should be dynamically incorporated into an institute's DBS paradigm to ensure that patients receive the optimal therapy.

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Dementia after DBS Surgery: A Case Report and Literature Review

Cited by 5 publications

References 38 publications

Neuropsychological effects of deep brain stimulation for Parkinson′s disease

Neuropsychological effects of deep brain stimulation for Parkinson′s disease

A Long Term Effects of a New Onset Psychosis after DBS Treated with Quetiapine in a Patient with Parkinson's Disease

Comparison of Globus Pallidus Interna and Subthalamic Nucleus in Deep Brain Stimulation for Parkinson Disease: An Institutional Experience and Review

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